A Wide Band Reflectance - DPOAE (WR-DP) Screener

宽带反射 - DPOAE (WR-DP) 筛选器

基本信息

批准号：
7001269
负责人：
PATRICIA S JENG
金额：
$ 61万
依托单位：
MIMOSA ACOUSTICS
依托单位国家：
美国
项目类别：
财政年份：
2004
资助国家：
美国
起止时间：
2004-03-01 至 2007-12-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7001269
关键词：
audiometry biomedical equipment development child (0-11)clinical research conductive hearing loss ear disorder diagnosis hearing disorders hearing tests human subject interview labyrinth otoacoustic emission questionnaires sensorimotor system sensorineural hearing loss

项目摘要

DESCRIPTION (provided by applicant): The goal of newborn hearing screening is to identity infants with inner ear pathology (IEP), but most neonates who fail screening have conductive disorders (CD) rather than IEP, resulting in high false positive rates and costly follow-up diagnostic evaluation. The Rhode Island study (1993) has shown that the prevalence of conductive disorders (CD) over inner ear pathologies (IEP) to be 17 vs. 3-to-6 per 1000. While in N1CU the prevalence of CD over IEP rises to 36 vs. 23 per 1000. The ramifications of IEP and CD are different, so an accurate typing of the loss at the time of a newborn hearing screening is essential. The main objective of this proposal is to build a hearing-screening device that combines wideband reflectance measurement with DPOAE measurement into one system, where the former provides diagnostic evaluation for CD and the latter provides diagnostic evaluation for the IEP Thus in one test; both the conductive path and cochlear status are evaluated. Since both the reflectance measurement and the DPOAE measurement require an identical calibration step, the extra time needed to perform hearing screening, using the combined screening device, will be no more than few minutes. The benefit of the expected outcome is reduced false-positive rates, reduces follow up diagnostic costs, and reduced parental concern in the case of false positives. An important auxiliary benefit of the probe impedance, obtained by the reflectance measurement, is to allow for a direct estimate of the signal intensity level in the ear canal so as to mitigate the standing wave problem in the audiometric measurement. In conjunction with DPOAE measurement, the WR-DP screener will provide more accurate measurement above 3 kHz where standing wave problem occurs. The specific aims of Phase II are (1) to complete the development of the wideband reflectance-distortion product otoacoustic emission (WR-DP) screening device, toward improving its efficiency, reliability and ease of use; (2) to perform clinical studies, to obtain baseline data for the WR-DP screener, and (3) to demonstrate the diagnostic capabilities and cost effectiveness of the WR-DP screener.

描述（由申请人提供）：新生儿听力筛查的目的是对患有内耳病理学（IEP）的身份婴儿，但是大多数失败筛查的新生儿都有导电障碍（CD）而不是IEP，导致较高的假阳性率和昂贵的后续诊断评估。罗德岛州的研究（1993年）表明，内耳病理学（IEP）的导电性障碍（CD）的流行率为17，而每1000次的3至6。而在N1CU中，IEP上的CD的患病率上升到36 vs. 23 vs. 23 vs.每1000。该提案的主要目的是建立一种听力筛查装置，将宽带反射率测量与DPOAE测量结合到一个系统中，在该系统中，前者对CD进行了诊断评估，后者为IEP提供了诊断评估，因此在一项测试中为IEP提供了诊断评估。评估了导电路径和人工耳蜗状态。由于反射率测量和DPOAE测量都需要相同的校准步骤，因此使用组合筛选设备进行听力筛选所需的额外时间将不超过几分钟。预期结果的好处是降低假阳性率，降低后续诊断成本，并减少了父母的关注，而在假阳性的情况下。通过反射率测量获得的探针阻抗的重要辅助益处，是允许对耳道中的信号强度水平进行直接估计，从而减轻听觉测量中的常见波问题。与DPOAE测量结合使用，WR-DP筛选器将在发生直立波问题的情况下提供更准确的测量值。第二阶段的具体目的是（1）完成宽带反射率延伸产品耳声发射（WR-DP）筛选设备的开发，以提高其效率，可靠性和易用性；（2）进行临床研究，以获取WR-DP筛选器的基线数据，以及（3）证明WR-DP筛选器的诊断能力和成本效益。