A Wide-band Reflectance - DPOAE (WR-DP)Screener

宽带反射率 - DPOAE (WR-DP)Screener

• 批准号: 6736192
• 负责人: PATRICIA S JENG
• 金额: $ 20.09万
• 依托单位: MIMOSA ACOUSTICS
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-03-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6736192
• 关键词: audiometry; biomedical equipment development; child (0-11); clinical research; conductive hearing loss; ear disorder diagnosis; hearing disorders; hearing tests; human subject; interview; labyrinth; otoacoustic emission; questionnaires; sensorimotor system; sensorineural hearing loss; audiometry; biomedical equipment development; child (0-11); clinical research; conductive hearing loss; ear disorder diagnosis; hearing disorders; hearing tests; human subject; interview; labyrinth; otoacoustic emission; questionnaires; sensorimotor system; sensorineural hearing loss

DESCRIPTION (provided by applicant): The goal of newborn hearing screening is to identify infants with sensorineural hearing loss (SNHL), but most neonates who fail screening have conductive hearing loss (CHL) rather than sensorineural hearing loss, resulting in high false positive rate and costly follow-up diagnostic evaluation. The Rhode Island study (1993) has shown that the prevalence of CHL over SNHL to be 17 vs. 3-6 per 1000. While in NICU the prevalence of CHL over SNHL raises to 36 vs. 23 per 1000. The ramifications of SNHL and CHL are different, so an accurate typing of the loss at the time of a newborn hearing screening is essential. This main objective of this proposal is to build a hearing screening device that combines wideband reflectance measurement system (RMS) with DPOAE measurement system into one system, where the former provides diagnostic evaluation for conductive hearing loss and the later provides diagnostic evaluation for the SNHL. So in one test, both conductive path and cochlear status are evaluated. Since both the reflectance measurement and the DPOAE measurement share an identical measurement, the extra time needed to perform hearing screening using the combined screening device will be no more than few minutes. The benefit of the expected outcome is reduced false positive rate, reduce follow up diagnostic cost, and reduced parental concern. The specific aims of Phase I is (1) to demonstrate the feasibility of distinguishing between conductive disorders (CD) and the inner ear pathologies (IEP) by combining the use of distortion product otoacoustic emission (DPOAE) and wide-band power reflectance measurements (WB-PR) in a single instrument used for hearing screening prototype instrument. (2) To develop a prototype instrument that will demonstrate the feasibility of using WB-PR to address the standing wave problem.

描述（由申请人提供）：新生儿听力筛查的目的是识别具有感觉性听力损失（SNHL）的婴儿，但是大多数筛查失败的新生儿都具有导电性听力损失（CHL）而不是感觉性听力损失，从而导致较高的假阳性率和昂贵的随访诊断评估。罗德岛州的研究（1993年）表明，chl在SNHL上的普遍性为17 vs.每1000。该提案的主要目标是建立听力筛查设备，该设备将宽带反射率测量系统（RMS）与DPOAE测量系统结合在一起，为一个系统，前者为导电性听力损失提供诊断评估，后来为SNHL提供了诊断评估。因此，在一个测试中，都评估了导电路径和人工耳蜗状态。由于反射率测量和DPOAE测量都具有相同的测量，因此使用组合筛选设备进行听力筛查所需的额外时间将不超过几分钟。预期结果的好处是降低误报率，降低后续诊断成本以及降低父母的关注。 第一阶段的具体目的是（1）通过结合使用失真产物耳声发射（DPOAE）和宽带功率反射测量（WB-PR）的使用，以在听力筛选筛选原型仪器中使用失真产物耳声发射（DPOAE）和宽带功率反射测量（WB-PR），以证明将导电性疾病（CD）和内耳病理（IEP）区分的可行性。 （2）开发一种原型仪器，该仪器将证明使用WB-PR解决常规问题的可行性。