Howard/Hopkins Center for Reducing Asthma Disparities

霍华德/霍普金斯减少哮喘差异中心

• 批准号: 7123011
• 负责人: Georgia Dunston
• 金额: $ 58.41万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2008-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7123011
• 关键词: African American; airborne allergen; asthma; caucasian American; clinical research; cockroach; cooperative study; environmental adaptation; gene environment interaction; genetic susceptibility; health care service utilization; health education; human morbidity; human subject; low socioeconomic status; patient care personnel relations; patient oriented research; pyroglyphid; racial /ethnic difference; therapy compliance; training; urban area

DESCRIPTION (provided by applicant): Despite significant advances in our understanding of the pathophysiology of asthma and marked improvements in the therapies available to treat asthma, disadvantaged and minority communities still carry a disproportionate burden from asthma. The exact reasons for this phenomenon are unknown, however, a number of factors have been proposed to account for this disparity, including genetic differences in vulnerability to asthma or asthma severity, differential rates of environmental exposure (e.g. cockroaches, dust), differences in the accessibility and quality of asthma medical care for patients of differing socioeconomic status, and inadequate asthma self-management practices, including poor adherence with therapy. It is widely believed that these factors interact to cause the observed excess burden of asthma within low-income, minority populations. Howard University and Johns Hopkins University have a long and successful history of collaborative studies designed to evaluate asthma morbidity in low-income, African-American children and adults with asthma. This application draws on this rich history to propose the formal collaboration of these institutions and investigators as a part of the Howard/Hopkins Center for Reducing Asthma Disparities. Specifically, this application presents four research projects designed to collaboratively investigate factors associated with the disproportionate burden of asthma experienced by inner-city, African-American children and adults. This application includes studies that will evaluate both the underlying genetic factors that may contribute to the observed excess risk in African-American communities, as well as studies of provider-patient communication designed to assess intervention strategies for remediating this risk. In addition, an essential goal of the Howard/Hopkins Center for Reducing Asthma Disparities will be to create a culturally sensitive training environment that is truly reciprocal, and designed to both enrich and enhance the research potential and asthma management capabilities of both participating institutions.

描述（由申请人提供）： 尽管我们对哮喘病理生理学的理解取得了重大进展，并且治疗哮喘的疗法也有了显着改进，但弱势群体和少数族裔社区仍然承受着不成比例的哮喘负担。这种现象的确切原因尚不清楚，但是，已经提出了许多因素来解释这种差异，包括哮喘易感性或哮喘严重程度的遗传差异、环境暴露率的差异（例如蟑螂、灰尘）、不同社会经济地位患者的哮喘医疗护理的可及性和质量，以及哮喘自我管理实践不足，包括治疗依从性差。人们普遍认为，这些因素相互作用，导致低收入少数群体中哮喘负担过重。霍华德大学和约翰霍普金斯大学有着悠久而成功的合作研究历史，旨在评估低收入非裔美国哮喘儿童和成人的哮喘发病率。该申请利用这段丰富的历史，建议这些机构和研究人员作为霍华德/霍普金斯减少哮喘差异中心的一部分进行正式合作。具体来说，本申请提出了四个研究项目，旨在合作调查与内城区非裔美国儿童和成人所经历的哮喘负担过高相关的因素。该应用程序包括评估可能导致非裔美国人社区观察到的过度风险的潜在遗传因素的研究，以及旨在评估补救这种风险的干预策略的提供者与患者沟​​通的研究。此外，霍华德/霍普金斯减少哮喘差异中心的一个基本目标是创造一个真正互惠的文化敏感培训环境，旨在丰富和增强两个参与机构的研究潜力和哮喘管理能力。