Antimicrobial Chemicals in Allergic Disease

过敏性疾病中的抗菌化学品

• 批准号: 8678041
• 负责人: Jessica R Savage
• 金额: $ 18.15万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-15 至 2019-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8678041
• 关键词: 3 year old; 7 year old; Adult; Advisory Committees; African American; Allergens; Allergic; Allergic Disease; Allergic rhinitis; Asthma; Birth; Chemicals; Child; Childhood; Clinical; Cohort Studies; Commit; Data; Development; Disease Association; Dose; Eczema; Environmental Exposure; Environmental Risk Factor; Epidemiologic Studies; Epidemiologist; Epidemiology; Etiology; Exposure to; Faculty; Food; Food Hypersensitivity; Gene Expression; Genetic; Genomics; Goals; Gold; Hay fever; Health; Hispanics; Hospitals; Human; Human Microbiome; Hypersensitivity; Immune system; Immunology; Infant; Intestines; K-Series Research Career Programs; Lead; Life; Light; Lotion; Lung diseases; Measures; Medicine; Mentors; Methods; Organism; Parabens; Participant; Pathway interactions; Patients; Phenols; Population; Pregnancy; Prevalence; Prevention strategy; Public Health; Questionnaires; Recruitment Activity; Research; Research Personnel; Risk; Self Care; Source; Supplementation; Testing; Toothpaste; Training; Triclosan; United States; Variant; Vitamin D; Woman; Work; airborne allergen; anti-IgE; antimicrobial; career; cohort; disease phenotype; disorder prevention; early life exposure; environmental chemical; experience; high throughput analysis; in vivo; interest; microbial; microbial disease; novel; patient oriented research; placebo controlled study; prenatal; prospective; public health relevance; racial and ethnic; randomized placebo controlled trial; toxicant; urinary; volunteer

DESCRIPTION (provided by applicant): This career development award will provide Jessica Savage, MD, MHS with the necessary experience and training to become an independent investigator in Allergy and Immunology. The prevalence of allergic diseases such as asthma, food allergy, eczema, and hay fever has risen dramatically in recent decades in the United States. The reasons for these high rates of allergy are largely unknown, but are generally thought to be due to environmental exposures. In light of the growing evidence that disruption of the human microbiota-the mutualistic and commensal organisms that live within us- is associated with allergic disease, it is notable that the increase in allergy followed the widespread introduction of personal care products containing antimicrobial chemicals (triclosan and parabens), which were invented over 40 years ago. Dr. Savage's previous work demonstrated a novel association between these antimicrobial chemicals and allergy. In this proposal Dr. Savage will further explore the association between antimicrobial chemicals and allergy in young children (Aim 1), determine the source of exposure to these chemicals in children (Aim 2), and determine the effects of these chemicals on the human microbiome and gene expression, likely intermediates in their association with allergy (Aim 3). Dr. Savage will build on her previous formal training in epidemiology and develop expertise in the development of cohort and interventional studies, exposure assessment, and analysis of high-throughput genetic data, and contribute to our understanding of why allergy develops. Dr. Savage's career trajectory demonstrates a commitment to patient-oriented research. Her previous studies demonstrated that children with food allergy are taking far longer than previously assumed to outgrow their common childhood food allergies and that anti-IgE is rapidly effective for many, but not all patients with food allergy. With this proposal, Dr. Savage broadens her interest beyond food allergy and will study factors that influence the development of all allergic diseases. This research has the potential to lead to simple and effective strategies for the prevention of allergic disease. Dr. Savage's research will take place at the Channing Division of Network Medicine (CDNM) at Brigham and Women's Hospital. The CDNM is a leader in epidemiologic studies world-wide and her section has over 30 faculty investigators and 110 other research personnel. Dr. Savage will be mentored by Dr. Litonjua, a genetic epidemiologist with expertise in exposure assessments and microbial-disease associations. Her scientific advisory committee includes Dr. Diane Gold, an epidemiologist with experience with birth cohort studies and allergy development; Dr. Scott Weiss, a genomic epidemiologist with expertise in network analyses applied to allergic respiratory disease; and Dr. Russ Hauser, an environmental epidemiologist with expertise in the effects of environmental chemicals on human health. They have many years of experience mentoring junior faculty and are committed to Dr. Savage's long term goals of becoming a successful independent investigator.

描述（由申请人提供）：该职业发展奖将为 Jessica Savage（医学博士、MHS）提供成为过敏和免疫学独立研究者所需的经验和培训。近几十年来，美国哮喘、食物过敏、湿疹和花粉热等过敏性疾病的患病率急剧上升。过敏率如此高的原因在很大程度上尚不清楚，但通常认为是由于环境暴露所致。越来越多的证据表明，人类微生物群（生活在我们体内的共生共生生物）的破坏与过敏性疾病有关，值得注意的是，随着含有抗菌化学物质（三氯生）的个人护理产品的广泛使用，过敏症的人数有所增加。和对羟基苯甲酸酯），这是 40 多年前发明的。 Savage 博士之前的工作证明了这些抗菌化学物质与过敏之间存在新的关联。在本提案中，Savage 博士将进一步探讨抗菌化学物质与幼儿过敏之间的关联（目标 1），确定儿童接触这些化学物质的来源（目标 2），并确定这些化学物质对人类微生物组的影响和基因表达，可能是与过敏相关的中间体（目标 3）。 Savage 博士将在她之前接受的流行病学正规培训的基础上，发展队列和干预研究、暴露评估和高通量遗传数据分析方面的专业知识，并为我们理解过敏发生的原因做出贡献。 Savage 博士的职业轨迹表明了他对以患者为中心的研究的承诺。她之前的研究表明，患有食物过敏的儿童需要比以前认为的更长的时间才能摆脱常见的儿童食物过敏，并且抗 IgE 对许多（但并非所有）食物过敏患者迅速有效。通过这项提议，萨维奇博士将她的兴趣扩展到食物过敏之外，并将研究影响所有过敏性疾病发展的因素。 这项研究有可能产生简单有效的预防过敏性疾病的策略。 Savage 博士的研究将在布莱根妇女医院钱宁网络医学部 (CDNM) 进行。 CDNM 是全球流行病学研究领域的领导者，其部门拥有 30 多名研究人员和 110 名其他研究人员。 Savage 博士将得到 Litonjua 博士的指导，Litonjua 博士是一位遗传流行病学家，在暴露评估和微生物疾病关联方面拥有专业知识。她的科学顾问委员会成员包括 Diane Gold 博士，她是一位流行病学家，在出生队列研究和过敏发展方面拥有丰富的经验； Scott Weiss 博士，一位基因组流行病学家，擅长应用于过敏性呼吸道疾病的网络分析； Russ Hauser 博士是一位环境流行病学家，在环境化学物质对人类健康的影响方面拥有专业知识。他们拥有多年指导初级教师的经验，并致力于实现 Savage 博士成为一名成功的独立研究者的长期目标。