H/H-ASTHMA (HGC)

H/H-哮喘 (HGC)

• 批准号: 7607814
• 负责人: Georgia Dunston
• 金额: $ 5.55万
• 依托单位: HOWARD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-03-01 至 2008-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7607814
• 关键词: Accounting; Adherence; Adult; African American; Asthma; Child; Collaborations; Communication; Communities; Computer Retrieval of Information on Scientific Projects Database; Dictyoptera; Disadvantaged; Dust; Environment; Environmental Exposure; Funding; Genetic; Goals; Grant; Institution; Intervention; Low income; Medical; Minority; Numbers; Patient Care; Patients; Provider; Rate; Recording of previous events; Research; Research Personnel; Research Project Grants; Resources; Risk; Self Management; Severities; Source; Training; United States National Institutes of Health; design; experience; inner city; socioeconomics

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. Despite significant advances in our understanding of the pathphysiology of asthma and marked improvements in the therapies available to treat asthma, disadvantaged and minority communities still carry a disproportionate burden from asthma. The exact reasons for this phenomenon are unknown, however, a number of factors have been proposed to account for this disparity, including genetic differences in vulnerability to asthma or asthma severity, differential rates of environmental exposure (e.g. cockroaches, dust) differences in the accessibility and quality of asthma medical care for patients of differing socioeconomic sttus and inadequate asthma self-management practices, including poor adherence with therapy. It is widely believed that these factors interact to cause the observed excess burden of asthma within low-income, African American children and adults with asthma. This application draws on this rich history to propose the formal collaboration of these institutions and investigators as a part of the Howard/Hopkins Center for Reducing Asthma Disparities. Specifically, this application presents four research projects designed to collaboratively investigate factors associated with the disproportiate burden of asthma experienced by inner-city African-American children and adults. This application includes studies that will evalute both the underlying genetic factors that may contribute to the observed excess risk in African- American communities, as well as studies or provider-patient communication designed to assess intervention strategies for remediating this risk. In addition, an essential goal of the Howard/Hopkins Center for Reducing Asthma Disparities will be to create a culturally sensitive training environment that is truly reciprocal, and designed to both enrich and enhance the research potential and asthma management capabilites of both participating institutions.

该子项目是利用该技术的众多研究子项目之一 资源由 NIH/NCRR 资助的中心拨款提供。子项目及 研究者 (PI) 可能已从 NIH 的另一个来源获得主要资金， 因此可以在其他 CRISP 条目中表示。列出的机构是 中心，不一定是研究者的机构。 尽管我们对哮喘病理生理学的理解取得了重大进展，并且治疗哮喘的疗法也有了显着改进，但弱势群体和少数族裔社区仍然承受着不成比例的哮喘负担。 这种现象的确切原因尚不清楚，但是，已经提出了许多因素来解释这种差异，包括哮喘易感性或哮喘严重程度的遗传差异、环境暴露率（例如蟑螂、灰尘）的差异以及可及性的差异不同社会经济状况和哮喘自我管理实践不足（包括治疗依从性差）的患者的哮喘医疗护理质量。 人们普遍认为，这些因素相互作用，导致低收入非裔美国哮喘儿童和成人哮喘负担过重。 该申请利用这段丰富的历史，建议这些机构和研究人员作为霍华德/霍普金斯减少哮喘差异中心的一部分进行正式合作。 具体来说，本申请提出了四个研究项目，旨在合作调查与内城区非裔美国儿童和成人所经历的哮喘负担不成比例相关的因素。 该应用程序包括评估可能导致非裔美国人社区观察到的过度风险的潜在遗传因素的研究，以及旨在评估补救这种风险的干预策略的研究或提供者与患者的沟通。 此外，霍华德/霍普金斯减少哮喘差异中心的一个基本目标是创造一个真正互惠的文化敏感培训环境，旨在丰富和增强两个参与机构的研究潜力和哮喘管理能力。