EARLY CHARACTERISTICS AND INTERVENTION IN AUTISM

自闭症的早期特征和干预

基本信息

批准号：
7551707
负责人：
Geraldine Dawson
金额：
$ 50.03万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2007
资助国家：
美国
起止时间：
2007-06-26 至 2008-04-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7551707
关键词：
Accounting Address Adult Aftercare Age Autistic Disorder Behavior Therapy Behavioral Biological Psychiatry Birth Brain Brain Chemistry Brain imaging Characteristics Child Child Psychology Chronic Cognitive Collaborations Commit Communication Depth Development Developmental Delay Disorders Discipline Early Intervention Early identification Elephants Etiology Event Eye Face Processing Family Functional Magnetic Resonance Imaging Functional disorder Genetic Goals Growth Head circumference Impairment Individual Individual Differences Infant Intervention Knowledge Language Life Light Magnetic Resonance Imaging Magnetic Resonance Spectroscopy Measures Medial Methods Nature Neurobiology Neurocognitive Neuropsychology Outcome Paper Pattern Persons Phenotype Prevention Process Psychiatry Psychology Psychopathology Psychophysiology Purpose Radiology Specialty Randomized Range Rare Diseases Research Resources Risk Scientist Severities Social Behavior Stimulus Structure Subgroup Susceptibility Gene Symptoms Techniques Temporal Lobe Toddler Universities Variant Washington base blind brain electrical activity cognitive neuroscience communication behavior developmental disease genetic analysis improved indexing interest men neurobehavioral neuropsychological programs response social social cognition social communication

项目摘要

This project has three broad goals: (1) to improve early identification of autism, (2) to assess the efficacy of early intensive behavioral intervention (EIBI) for treatment of autism, and (3) to better understand individual child factors that account for variability in response to EIBI. The specific aims are: 1. To identify cognitive, social, neuropsychological, and electrical brain activity differences between 18-24 month old toddlers with autism versus 18-24 month olds with developmental (cognitive) delay (DD) and typical development. 2. To conduct a randomized study of EIBI to evaluate the efficacy of EIB! for improving outcomes of young children with autism, based on measures of cognitive, language, and social behavior. 3. To also evaluate the efficacy of EIBI for improving outcomes based on measures of brain activity. Our previous studies have shown that children with autism show atypical patterns of event related brain potentials in response to social stimuli. Given the emphasis on improving social behavior (e.g., eye contact) in EIBI, it is possible that EIBI may result in improved outcome on brain measures related to social processing. We will determine whether EIBI results in changes in brain activity such that, after treatment, children who have received EIBI will show more normal patterns of brain activity than those who do not receive such intervention. 4. To identify individual child factors that account for variation in response to EIBI in young children with autism. We hypothesize that three child factors will be important predictors of response to intervention. These are (1) IQ, (2) severity of autism symptoms, and (3) degree of early brain impairment, specifically, degree of medial temporal lobe dysfunction. A better understanding of factors related to response to early intervention would inform decisions regarding appropriate, individualized intervention methods and elucidate brain mechanisms involved in autism.

该项目具有三个广泛的目标：（1）改善自闭症的早期识别，（2）评估早期强化行为干预（EIBI）对自闭症治疗的疗效，以及（3）更好地了解对EIBI响应可变性的个体儿童因素。具体目的是：1。确定自闭症18-24个月大的幼儿之间的认知，社会，神经心理学和电脑活动差异与具有发育（认知）延迟（DD）和典型发展的18-24个月大的孩子。 2。进行EIBI的随机研究以评估EIB的功效！根据认知，语言和社会行为的措施，改善自闭症患者的结果。 3。还评估EIBI基于大脑活动的度量改善结果的功效。我们以前的研究表明，自闭症儿童表现出与事件相关的大脑的非典型模式响应社会刺激的潜力。鉴于强调在EIBI中改善社会行为（例如，眼神交流），EIBI可能会导致与社会处理相关的脑测量结果改善。我们将确定EIBI是否会导致大脑活动的变化，以便在治疗后，接受EIBI的儿童比未接受这种干预的孩子会显示出更正常的大脑活动模式。 4。确定自闭症幼儿响应EIBI的差异的单个儿童因素。我们假设三个儿童因素将是对干预反应的重要预测指标。这些是（1）智商，（2）自闭症症状的严重程度和（3）早期脑损伤的程度，特别是内侧颞叶功能障碍的程度。更好地理解与早期干预反应有关的因素，将为有关适当的个性化干预方法的决策提供信息，并阐明涉及自闭症的大脑机制。