Administrative Core

行政核心

基本信息

批准号：
10698185
负责人：
Geraldine Dawson
金额：
$ 25.66万
依托单位：
DUKE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-07 至 2027-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10698185
关键词：
Accounting Address Advisory Committees Biological Markers Brain Clinical Clinical Trials Collaborations Communication Communities Computer software Computing Methodologies Data Data Analyses Databases Decision Making Early identification Ensure Environment Equity Ethics Expenditure Faculty Family Goals Good Clinical Practice Guidelines Health Services Accessibility Human Resources Individual Infrastructure Institution Institutional Review Boards Intervention Knowledge Monitor Occupational activity of managing finances Outcome Outcome Measure Patient Recruitments Phase Policies Postdoctoral Fellow Principal Investigator Procedures Process Productivity Progress Reports Publications Quality Control Quality of life Recommendation Regulation Research Research Personnel Research Project Grants Resources Screening procedure Stratification Students Sum Technology Underrepresented Populations United States National Institutes of Health Universities Work autism spectrum disorder autistic children benefit sharing biomarker discovery brain based career clinical care community engagement cost effectiveness data management digital health improved innovation insight meetings member outreach programs synergism

项目摘要

ABSTRACT – Administrative Core The overall goal of the Duke Autism Center of Excellence (ACE) is to use a translational digital health and computational approach to address the critical need for more effective early autism screening tools, objective and sensitive outcome measures, and brain-based biomarkers that can be used in clinical trials with young autistic children. We will achieve our goals by harnessing shared technologies, computational methods, and clinical expertise across three Projects and with the support of three Cores: The Dissemination and Outreach Core, the Data Management and Analysis Core, and the Administrative Core. The Administrative Core will serve as the Center’s “hub”, coordinating and overseeing all Projects and Cores so they function effectively and efficiently as a whole in an integrated and synergistic fashion. The Administrative Core will promote an inclusive, equitable environment of communication and collaboration among investigators, reduce administrative burden on investigators, provide financial oversight, monitor regulatory compliance, and ensure scientific rigor and productivity. The Core will be directed by Center Director and Principal Investigator, Dr. Geraldine Dawson, who will work closely with expert administrative staff, an internal Executive Committee, a Community Engagement Advisory Board, and an External Advisory Committee. The Administrative Core has three specific aims. First, the Core will coordinate communication, data-sharing, and collaboration among Center investigators to enhance cross-Projects synergies, shared expertise and resources, and scientific progress through all phases of the research program. Second, the Core will provide overall management and oversight of the Center. The Core will oversee and support the Center’s scientific efforts by setting goals, defining deliverables, and monitoring progress, ensuring timely advancement toward milestones and deliverables. Third, the Core will provide timely financial accounting and ensure compliance with institutional, state, and federal research and ethical guidelines, quality control, and cost-effectiveness. The Core will be responsible for providing expertise and infrastructure for strong financial management; ensuring compliance with university, state, NIH, and other federal research regulations; managing Institutional Review Board submissions and communication; developing and disseminating Standard Operating Procedures; implementing Good Clinical Practice; maintaining research fidelity; overseeing quality control; and ensuring timely submissions to the National Database for Autism Research.

摘要 – 行政核心杜克大学自闭症卓越中心 (ACE) 的总体目标是利用转化型数字健康和计算方法来满足对更有效的早期自闭症筛查工具的迫切需求，目标和敏感的结果测量，以及可用于年轻人临床试验的基于大脑的生物标志物我们将通过利用共享技术、计算方法和方法来实现自闭症儿童的目标。跨三个项目的临床专业知识并在三个核心的支持下：传播和外展核心、数据管理和分析核心以及管理核心。作为中心的“枢纽”，协调和监督所有项目和核心，使它们有效运作行政核心将作为一个整体以综合和协同的方式高效地促进包容性、调查人员之间公平的沟通和协作环境，减轻行政负担对调查人员进行财务监督，监督监管合规情况，确保科学监管和该核心项目将由中心主任兼首席研究员杰拉尔丁·道森 (Geraldine Dawson) 博士领导。将与专家管理人员、内部执行委员会、社区参与密切合作咨询委员会和外部咨询委员会有三个具体目标：核心将协调中心研究人员之间的沟通、数据共享和协作，以加强跨项目协同作用、共享专业知识和资源以及整个项目各个阶段的科学进步其次，核心将提供中心的全面管理和监督。通过设定目标、确定可交付成果和监测来监督和支持中心的科学工作第三，核心将及时提供支持。财务会计并确保遵守机构、州和联邦研究和道德准则，质量控制和成本效益核心将负责提供专业知识和基础设施。强大的财务管理；确保遵守大学、州、NIH 和其他联邦研究的要求法规；管理机构审查委员会的提交和沟通；传播标准操作程序，维持研究；保真度；监督质量控制；并确保及时向国家自闭症数据库提交信息研究。