Administrative Core

行政核心

• 批准号: 10712291
• 负责人: DAPHNE A. HAAS-KOGAN
• 金额: $ 5.17万
• 依托单位: DANA-FARBER CANCER INST
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-09-19 至 2028-08-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10712291
• 关键词: Accounting; Achievement; Address; Adult; Advisory Committees; Advocate; Archives; Artificial Intelligence; Award; Biometry; Boston; Cancer Biology; Cells; Client; Clinical; Clinical Research; Clinical Trials; Code; Communication; Communication Methods; Communities; Community Services; Computer Models; Dana-Farber Cancer Institute; Daphne plant; Data; Data Science; Data Science Core; Data Set; Databases; Department chair; Doctor of Medicine; Doctor of Philosophy; Education and Outreach; Electronic Mail; Electronics; Evaluation; Face; General Population; Genome; Goals; Grant; Hospitals; Image; Institution; Leadership; Logistics; Machine Learning; Malignant Childhood Neoplasm; Medical; Mission; Molecular; Nature; Occupational activity of managing finances; Oncology; Patient advocacy; Patients; Pediatric Hospitals; Pediatric Oncology; Performance; Persons; Pharmacology; Physics; Pilot Projects; Protocols documentation; Quality of life; Radiation; Radiation Oncology; Reporting; Request for Applications; Research; Research Personnel; Research Project Grants; Resource Sharing; Resources; Science; Services; Site; Source; Talents; Technology; Text; Training; Videoconferencing; Vision; Woman; Work; cloud based; design; dosimetry; experience; mathematical model; meetings; multidisciplinary; neoplastic cell; outreach program; participant enrollment; pediatric patients; physical science; programs; radiation resistance; radiation response; radioligand; recruit; repository; resistance mechanism; sharing platform; skills; theranostics; tool; web site

The Harvard/UCSF ROBIN Center will address molecular mechanisms of radiation response and resistance in childhood cancers, using the “quieter” genome of pediatric malignancies to identify radiation resistance mechanisms that are broadly applicable to adult and pediatric patients. The Center consists of a Molecular Characterization Trial, two Research Projects, two supporting Cores [one focused on Data Science and Advanced Dosimetry and the second on Imaging and Artificial Intelligence (AI)] as well as the critical Cross- Training Core (ROBIN-NEST). Collectively, these ROBIN Center components can be conceptualized as either “Scientific” or “Programmatic” in nature. Against this backdrop, this Administrative Core has two broad goals. Firstly, as the ROBIN Center’s “inward looking face”, the Administrative Core will support the Scientific and Programmatic missions. Secondly, the Administrative Core will serve as the “outward face” of the Harvard/UCSF Center and as point of contact with NCI, other ROBIN Centers, diverse learners, the radiation sciences workforce, and the lay public. The Administrative Core has three Specific Aims. Aim 1 (Scientific Support): The Administrative Core will implement electronic communication methods to facilitate transfer of accounting information, access to Research and Technology Management forms, access to clinical research databases, and access to cloud-based data and code sharing platforms. Aim 2 (Programmatic Support): The Core will integrate the Harvard/UCSF sites and unify the Center via videoconferencing, in-person meetings, and online communication. Together with the ROBIN-NEST, the Core will host an Annual Retreat to share and harmonize vision and logistics across the ROBIN Center. Finally, the Core will request applications for, evaluate, award, and administer pilot and trans-Network Projects. Aim 3 (NCI and Community Service): The Administrative Core will create the Harvard/UCSF ROBIN Center’s website as a public-facing source of data and resources. Critically, the Core will also work to strengthen the Harvard/UCSF Center with proactive strategies to enhance diversity of our research groups, the radiation sciences workforce, communities served by our Center, and patients enrolled in our clinical trials. Daphne Haas-Kogan, M.D. and Franziska Michor, Ph.D. will serve as co-leaders of the Administrative Core and also as co-PIs of the Harvard/UCSF ROBIN itself. Each of the co-leads has extensive experience in leading multi-investigator, multi-institutional research initiatives. Dr. Haas-Kogan is the Chair of the Department of Radiation Oncology at Dana-Farber Cancer Institute (DFCI), Brigham and Women’s Hospital, and Boston Children’s Hospital, and Dr. Michor has led two iterations of NCI’s Physical Sciences Oncology Network’s (PSON) U54 initiative and also leads the DFCI Physical Sciences Oncology Center (DFCI PSOC). Drs. Haas- Kogan and Michor will be assisted by Simon Maisel, MS, who will report directly to the co-PIs.

哈佛/UCSF罗宾中心将解决辐射响应和电阻的分子机制 在儿童期癌症中，使用儿科恶性肿瘤的“更安静”的基因组来识别辐射抗性 广泛适用于成人和小儿患者的机制。该中心由分子组成 表征试验，两个研究项目，两个支持核心[一个专注于数据科学和 先进的剂量法和第二个关于成像和人工智能（AI）的剂量）以及关键的横界 训练核心（Robin-Nest）。总的来说，这些罗宾中心的组件可以被概念化为 本质上要么“科学”或“程序化”。 在这种背景下，这个行政核心有两个广泛的目标。首先，作为罗宾中心的 行政核心“向内看的面孔”将支持科学和程序化任务。第二， 行政核心将充当哈佛/UCSF中心的“向外面”，并作为联系点 与NCI，其他罗宾中心，潜水员学习者，辐射科学劳动力和外行公众。 行政核心具有三个具体目标。 目标1（科学支持）：行政核心将实施电子通信 促进会计信息，访问研究和技术管理的方法 表格，访问临床研究数据库以及访问基于云的数据和代码共享平台。 AIM 2（程序化支持）：核心将整合哈佛/UCSF网站并统一中心 通过视频会议，面对面的会议和在线沟通。与罗宾 - 纽斯一起， Core将举办年度务虚会，以分享和协调罗宾中心的视觉和物流。最后， 核心将要求申请，评估，授予和管理飞行员和跨网络项目。 AIM 3（NCI和社区服务）：行政核心将创建哈佛/UCSF 罗宾中心的网站是公开的数据和资源来源。至关重要的是，核心也将作用于 通过积极的策略来加强哈佛/UCSF中心，以增强我们的研究小组的多样性， 辐射科学劳动力，我们中心服务的社区以及参加我们临床试验的患者。 Daphne Haas-Kogan，医学博士和Franziska Michor博士将担任行政的共同领导者 核心，也是哈佛大学/UCSF罗宾本身的副派。每个共同领导者都有丰富的经验 领先的多机构多机构研究计划。 Haas-Kogan博士是该部门的主席 Dana-Farber癌症研究所（DFCI），Brigham and妇女医院的辐射肿瘤学和波士顿 儿童医院和Michor博士领导了NCI物理科学网络的两次迭代 （PSON）U54计划，还领导DFCI物理科学肿瘤学中心（DFCI PSOC）。博士。 haas- Kogan和Michor将由MS Simon Maisel协助，他们将直接向Co-Pis报告。