Impacts of Air Pollution from Ultrafine Tire-Wear Particles on Cardiorespiratory Health

超细轮胎磨损颗粒造成的空气污染对心肺健康的影响

• 批准号: 2899750
• 金额: --
• 依托单位: University of Manchester
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2023
• 资助国家: 英国
• 起止时间: 2023 至 无数据
• 项目状态: 未结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-2899750
• 关键词: Impacts; Air; Pollution; Ultrafine; Tire

Due to reduction in engine emissions from vehicles, the relative contribution of tire-wear in total traffic related air pollution is increasing [1]. However, our understanding of the health effects of ultrafine tire particles is still limited. Light-duty tires are typically made up of synthetic rubber, derived from crude oil, rather than natural rubber. This increases the polycyclic aromatic hydrocarbon (PAH) component of tires, and the potential cardiotoxicity of tire-related particulate matter (PM) [2]. For this PhD CASE project, the student will work closely with our Industrial Partner, Emissions Analytics [3] who is global leader in independent testing of realworld emissions for passenger and commercial vehicles. Here the student will learn cutting-edge chemical analytics techniques and generate real-life tire-wear particles for use in their biomedical test systems. At the University of Manchester, the PhD candidate will investigate the impact of air pollution from tire-wear on human health using lung and cardiac in vitro assay systems focussing on each system independently as well as the interconnectivity between lung and heart systems. To relate findings from the in vitro systems studies to human population health, the project will finish with an epidemiological investigation which adapts current exposure models of PM pollution and health [4] to include PM from tire-wear.

由于车辆发动机排放量的减少，轮胎磨损在交通相关空气污染总量中的相对贡献正在增加[1]。然而，我们对超细轮胎颗粒对健康影响的了解仍然有限。轻型轮胎通常由从原油中提取的合成橡胶制成，而不是天然橡胶。这会增加轮胎中的多环芳烃 (PAH) 成分，以及轮胎相关颗粒物 (PM) 的潜在心脏毒性 [2]。对于这个博士 CASE 项目，学生将与我们的工业合作伙伴 Emissions Analytics [3] 密切合作，该合作伙伴是乘用车和商用车实际排放独立测试的全球领导者。在这里，学生将学习尖端的化学分析技术，并生成现实生活中的轮胎磨损颗粒，用于其生物医学测试系统。在曼彻斯特大学，博士生将使用肺和心脏体外检测系统研究轮胎磨损造成的空气污染对人类健康的影响，重点关注每个系统独立以及肺和心脏系统之间的互连性。为了将体外系统研究的结果与人类健康联系起来，该项目将以流行病学调查结束，该调查将采用当前的 PM 污染和健康暴露模型 [4]，将轮胎磨损产生的 PM 纳入其中。