2006 Grover Conference on the Pulmonary Circulation - Rho Family GTPases

2006 Grover 肺循环会议 - Rho 家族 GTPases

• 批准号: 7112851
• 负责人: KAREN A. FAGAN
• 金额: $ 2.9万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-05 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7112851
• 关键词: guanosinetriphosphatases; lung disorder; meeting /conference /symposium; pathologic process; pulmonary circulation; travel

DESCRIPTION (provided by applicant): This application requests funding to support the 2006 Graver Conference on the Pulmonary Circulation entitled "Rho Family GTPases in Pulmonary Vascular Pathophysiology." This conference seeks to integrate state of the art bench research with clinical problems that are leading causes of morbidity and mortality from lung disease. The important roles Rho family GTPases (e.g. RhoA, Cdc42, and Rac1) play in lung biology and pathology are rapidly emerging. These signaling molecules have been implicated in a wide variety of cellular functions (contraction, permeability, inflammation, proliferation, migration, gene expression, differentiation) and are emerging as therapeutic targets in systemic and pulmonary vascular diseases. Indeed, the pleiotropic statins may act in part by inhibiting the activation of Rho GTPases. Inhibitors of Rho-kinase are available for in trials for treatment of cerebral and coronary artery vasospasm. The multifaceted role that Rho GTPases play in the pulmonary circulation is evolving toward treatments for pulmonary hypertension, ARDS, pulmonary edema, etc. However, there has not yet been a single, comprehensive conference to promote interaction and exchange of ideas amongst investigators interested in Rho GTPases in lung biology and pathology. Specifically, the 2006 Grover Conference seeks to provide a forum for experts in the cellular biology of Rho GTPases and in lung and vascular biology to rigorously address the: (1) Cell biology of Rho family GTPases including activation, signaling, etc., (2) Regulation of pulmonary vascular tone and activity through Rho family GTPase signaling, i.e., calcium sensitization and smooth muscle contraction, endothelial permeability, (3) Recruitment and activation of inflammatory cells to the lung following injury, etc., and (4) Rho family GTPases as therapeutic targets in medicine (e.g. pulmonary hypertension, ARDS, etc.). The 2006 Grover Conference will be the 13th in this series, representing the longest-standing conference on the pulmonary circulation. Equal time is given to presentation and discussion to optimize interaction. The conference will be held at the Lost Valley Ranch in Sedalia, CO September 6-10, 2006. The ranch is an intimate setting that encourages interaction between scientists and clinicians. We are requesting funding to support travel and lodging for invited speakers.

描述（由申请人提供）： 本申请请求资金支持 2006 年 Graver 肺循环会议 题为“肺血管病理生理学中的 Rho 家族 GTPases”。本次会议旨在将最先进的基础研究与导致肺部疾病发病和死亡的主要原因的临床问题结合起来。 Rho 家族 GTPases（例如 RhoA、Cdc42 和 Rac1）在肺生物学和病理学中发挥的重要作用正在迅速显现。这些信号分子与多种细胞功能（收缩、通透性、炎症、增殖、迁移、基因表达、分化）有关，并正在成为全身和肺血管疾病的治疗靶点。事实上，多效性他汀类药物可能部分通过抑制 Rho GTP 酶的激活来发挥作用。 Rho 激酶抑制剂可用于治疗脑动脉和冠状动脉血管痉挛的试验。 Rho GTPases 在肺循环中发挥的多方面作用正在演变为治疗肺动脉高压、ARDS、肺水肿等。然而，目前还没有一个单一的、全面的会议来促进对 Rho 感兴趣的研究人员之间的互动和思想交流。 GTPases 在肺生物学和病理学中的应用。具体而言，2006 年 Grover 会议旨在为 Rho GTP 酶细胞生物学以及肺和血管生物学领域的专家提供一个论坛，以严格解决以下问题：(1) Rho 家族 GTP 酶的细胞生物学，包括激活、信号传导等，(2 ) 通过 Rho 家族 GTPase 信号传导调节肺血管张力和活性，即钙敏化和平滑肌收缩、内皮通透性，(3) 炎症细胞募集和激活(4)Rho家族GTP酶作为医学上的治疗靶点(例如肺动脉高压、ARDS等)。 2006 年 Grover 会议将是该系列会议的第 13 次，代表着历史最悠久的肺循环会议。演示和讨论的时间相同，以优化互动。会议将于 2006 年 9 月 6 日至 10 日在科罗拉多州锡代利亚的 Lost Valley Ranch 举行。该牧场是一个鼓励科学家和临床医生互动的亲密环境。我们正在请求资金来支持受邀演讲者的旅行和住宿。