Molecular Pathology of Lung Cancer

肺癌的分子病理学

• 批准号: 6943244
• 负责人: JOHN D. MINNA
• 金额: $ 2万
• 依托单位: AMERICAN ASSOCIATION FOR CANCER RESEARCH
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-04 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6943244
• 关键词: disease /disorder model; drug addiction; gene expression profiling; genetic susceptibility; lung neoplasms; mass screening; meeting /conference /symposium; molecular pathology; neoplasm /cancer diagnosis; neoplasm /cancer therapy; nicotine; proteomics; smoking cessation; travel

DESCRIPTION (provided by applicant): The aim of this proposal is to organize a scientific meeting entitled "Opportunities for Translation of the Molecular Pathogenesis of Lung Cancer to the Clinic", in San Diego, California from February 23 - 27, 2005. This AACR Special Conference brings together scientists and physicians that are leaders in the basic, translational, and clinical fields of lung cancer research. Lung cancer is the biggest cancer killer of men and women in the USA and in many countries around the world. This conference focuses on the many new important translational advances dealing with all aspects of lung cancer that promise a rationale approach to stopping this deadly disease. These include: understanding its molecular pathogenesis; genetic epidemiology; genetics of nicotine addiction and response to anti-smoking therapy; strategies for early detection including molecular detection; chemoprevention; molecular profiling (mRNA, proteomic, and DMA) of tumors and blood to provide detailed information on lung cancer clinical behavior and prediction of response to therapy; new imaging approaches for diagnosis and evaluation of therapeutic response; and the development of new targeted therapies. In addition, the development of animal, particularly mouse models of lung cancer provide an important new avenue to systematically understand and attack this disease. The group of speakers who have agreed to participate are some of the leading transdisciplinary investigators in these fields and are active in seeking to translate their findings to and from the clinic and the laboratory.

说明（由申请人提供）：本提案的目的是于 2005 年 2 月 23 日至 27 日在加利福尼亚州圣地亚哥组织一次题为“将肺癌分子发病机制转化为临床的机会”的科学会议。本 AACR特别会议汇聚了肺癌研究基础、转化和临床领域的科学家和医生。肺癌是美国和世界许多国家男性和女性的最大癌症杀手。本次会议重点关注涉及肺癌各个方面的许多新的重要转化进展，这些进展有望为阻止这种致命疾病提供合理的方法。这些包括：了解其分子发病机制；遗传流行病学；尼古丁成瘾的遗传学和对戒烟治疗的反应；早期检测策略，包括分子检测；化学预防；肿瘤和血液的分子分析（mRNA、蛋白质组和 DMA），提供有关肺癌临床行为和治疗反应预测的详细信息；用于诊断和评估治疗反应的新成像方法；以及新的靶向疗法的开发。此外，动物（尤其是小鼠）肺癌模型的开发为系统地了解和攻击这种疾病提供了重要的新途径。同意参加的演讲者小组是这些领域的一些领先的跨学科研究人员，他们积极寻求将他们的发现转化为临床和实验室。