CNS Manifestations of Tuberous Sclerosis Complex

结节性硬化症的中枢神经系统表现

• 批准号: 6941500
• 负责人: VICKY HOLETS WHITTEMORE
• 金额: $ 4万
• 依托单位: TUBEROUS SCLEROSIS ALLIANCE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2006-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6941500
• 关键词: cell differentiation; cell migration; cell proliferation; congenital brain disorder; epilepsy; genetic disorder; lung disorder; lymphangioleiomyomatosis; meeting /conference /symposium; travel; tuberous sclerosis

DESCRIPTION (provided by applicant): The CNS Manifestations of Tuberous Sclerosis Complex Conference will be a two and a half day conference held in conjunction with the annual LAMposium, a conference on lymphangioleiomyomatosis (LAM), and the annual Rare Lung Disease Consortium Conference. The basic biology of LAM indicates that the TSC2, and perhaps the TSC1 gene, play a significant role in LAM, so the last two LAMposiums have included numerous sessions focused on the function of the TSC2 gene in the lung and kidney. Because there is so much overlap in the basic science of these two diseases, it is critical that these two research communities come together to discuss common interests. Holding these conferences together will allow for discussions between the TSC and LAM researchers, and interactions with the researchers who study other rare lung diseases. Holding these conferences together will also be cost-effective because there is significant overlap in the speakers and individuals who will attend these conferences. The Tuberous Sclerosis Alliance is working closely with the LAM Foundation and the Rare Lung Disease Consortium to coordinate the conferences and all conference activities. The goal of the CNS Manifestations of Tuberous Sclerosis Complex Conference is to develop a roadmap for TSC research for the NIH, TSCRP in the CDMRP, and the Tuberous Sclerosis Alliance, building on the TSC research agenda that was developed by NIH as a result of the conference funded by NIH and the TS Alliance in September 2002. The three main topics to be covered in this conference are: 1. Cell Proliferation, Migration and Differentiation in TSC. 2. What Causes Epilepsy in TSC? 3. Cognitive and Psychiatric Issues in TSC.

描述（由申请人提供）：结节性硬化症的中枢神经系统表现综合会议将是一个为期两天半的会议，与年度 LAMposium、淋巴管平滑肌瘤病 (LAM) 会议和年度罕见肺病联盟会议同时举行。 LAM 的基础生物学表明 TSC2（也许还有 TSC1 基因）在 LAM 中发挥着重要作用，因此最近两届 LAMposium 包括了许多重点关注 TSC2 基因在肺和肾中功能的会议。由于这两种疾病的基础科学有很多重叠之处，因此这两个研究团体聚在一起讨论共同利益至关重要。一起举办这些会议将使 TSC 和 LAM 研究人员之间进行讨论，并与研究其他罕见肺部疾病的研究人员进行互动。同时举办这些会议也将具有成本效益，因为出席这些会议的演讲者和个人有很大的重叠。结节性硬化症联盟正在与 LAM 基金会和罕见肺病联盟密切合作，协调会议和所有会议活动。结节性硬化症复合体中枢神经系统表现会议的目标是，以 NIH 制定的 TSC 研究议程为基础，为 NIH、CDMRP 中的 TSCRP 和结节性硬化症联盟制定 TSC 研究路线图。 2002 年 9 月由 NIH 和 TS Alliance 资助的会议。本次会议讨论的三个主要议题是： 1. 细胞增殖、迁移和TSC 的分化。 2. TSC 癫痫的原因是什么？ 3. TSC 的认知和精神问题。