Clinical Trials Network: North Texas Node

临床试验网络：北德克萨斯节点

• 批准号: 7437551
• 负责人: BRYON H. ADINOFF
• 金额: $ 32.03万
• 依托单位: UT SOUTHWESTERN MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-01 至 2010-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7437551
• 关键词: AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Address; Admission activity; Adolescent; Adult; African American; Alcohol abuse; Alcohol or Other Drugs use; Algorithms; Ancillary Study; Attention Deficit Disorder; Award; Bipolar Disorder; Characteristics; Child; Clinic; Clinical; Clinical Data; Clinical Research; Clinical Trials Network; Cognitive Therapy; Collaborations; Commit; Communities; Complement; Complex; Condition; Depressed mood; Development; Diagnosis; Disease; Doctor of Medicine; Doctor of Philosophy; Drug abuse; Drug usage; Effectiveness; Exhibits; Faculty; Fellowship; Female; Female Adolescents; Foundations; Funding; Future; Geographic Locations; Grant; HIV; Health; Health Personnel; Hispanics; Hospitals; Inpatients; Investigation; Joints; K-Series Research Career Programs; Latino; Lead; Medical center; Mental Depression; Mental disorders; Monitor; Multi-Institutional Clinical Trial; National Institute of Drug Abuse; Outpatients; Patients; Pattern; Performance; Pharmaceutical Preparations; Pharmacological Treatment; Pharmacotherapy; Policies; Population; Prevention; Primary Health Care; Procedures; Protocols documentation; Provider; Psychiatrist; Public Health; Range; Recording of previous events; Research; Research Personnel; Research Proposals; Research Training; Residencies; Risk; Screening procedure; Services; Site; Structure; Substance Use Disorder; Substance abuse problem; System; Texas; Training; Training and Education; United States National Institutes of Health; Universities; Vision; Voice; Woman; Work; addiction; austin; career; clinical research site; concept; court; data management; design; effectiveness clinical trial; experience; health care service utilization; interest; medical specialties; organizational structure; outreach program; pre-clinical; pre-doctoral; programs; response; success; transmission process

This application proposes a new ClinicalTrials Network(CTN) node representing North Texas. The North Texas Node (NTN) is comprised of the University of Texas Southwestern Medical Center in Dallas (TIT Southwestern) and seven Community Treatment Providers (CTPs) in Dallas, Ft. Worth, Austin,and El Paso. UT Southwesternbrings together a faculty with extensive experience in the preclinical and clinical study of substance u&edisorders, the design, implementation, and analysis of multi-site, efficacy-effectiveness clinical trials in both adolescents and adults the pharmacological treatment of comorbid disorders, and cultural issues in addiction. UT Southwestern faculty will collaborate with CTPs representing over 11,000 annual inpatient and outpatient admissions for a primary substance use disorder, with large populations of Hispanic/Latino, African-American, adolescent, and female patients. The CTPs and associated sites also offer specialized treatment and outreach programs for HIV+ patients. The NTN utilizes an administrative and organizational structure that carefully considers the CTN structure, its policies and procedures, and the initiation of centralized clinical,data management/statistical, and logistical centers. The Node's organization also provides a strong voice to our CTPs, assuring their presence on all committees,teams, and workgroups. For example, the NTN has initiated mechanisms to develop new protocols that involve a joint CTP- UT Southwestern effort, as evidenced by our Concept Proposal that addresses an unmet clinicalneed identified by the Node's CTPs. This collaborative structure will enable the NTN to take the lead in the development of future of protocols within the CTN, in addition to ancillary and externally funded studies that maximize the CTN platform. This system also incorporates UT Southwestern's preclinical T32 and clinical R25 NIDA training grants to encourage resident, fellow, and faculty career development within the CTN, includingK awards. Protocol implementation will be assured by our exceptionally skilled management team and trainers from UT Southwestern's previous and ongoing multi-site clinical trials and a cadre of CTP sites with significant collaborative research experience.The effectiveness of the NTN in developing, implementing and disseminatingthe results of clinicaltrials will be assisted by the NTN's own Performance Assessment System, which will complement the CTN's performance monitors. Our ConceptProposal, which proposes a study of the effects of medication algorithms to treat adolescents with substance use and comorbid disorders, reveals our Node's ability to design state-of-the-arteffectiveness trials that maximize the potential of the CTN framework. We believe the structure and organization of the NTN, as well as its committed and highly experienced investigators, complements and extends the work of the CTN.

该应用程序提出了一个代表北德克萨斯州的新临床网络（CTN）节点。北德克萨斯州 Node（NTN）由达拉斯的德克萨斯大学西南医学中心（西南山雀）和 达拉斯的七个社区治疗提供者（CTP）。值得，奥斯丁和埃尔帕索。 UT西南脑 在临床前和临床研究中，具有丰富经验的教师 对青少年和成人的多站点，功效效应临床试验的实施和分析 合并症疾病的药理治疗和成瘾中的文化问题。 UT西南教师将 与CTPS合作，代表11,000多个年度住院和门诊入院，以供主要物质使用 疾病，大量的西班牙裔/拉丁裔，非裔美国人，青少年和女性患者。 CTP和 相关站点还为艾滋病毒+患者提供专门的治疗和外展计划。 NTN利用一种行政和组织结构，仔细考虑了CTN结构， 政策和程序，以及集中式临床，数据管理/统计和后勤中心的启动。 节点的组织还为我们的CTP提供了强烈的声音，确保他们在所有委员会，团队，， 和工作组。例如，NTN已经启动了开发涉及联合CTP-的新方案的机制 我们的西南努力，我们的概念提案证明了这一点 节点的CTP。这种协作结构将使NTN能够领导 除了最大化CTN平台的辅助和外部资助的研究外，CTN内的协议。这 系统还结合了UT西南的临床前T32和临床R25 NIDA培训补助金 CTN内的居民，研究员和教师职业发展，包括K奖。协议实施将是 由我们熟练熟练的管理团队和UT西南部以前和正在进行的培训师保证 多站点临床试验和具有重要协作研究经验的CTP站点的干部。 NTN在开发，实施和传播临床结果的结果时将由NTN自己的 性能评估系统，将补充CTN的性能监视器。我们的概念特征， 它提出了一项研究药物算法对使用药物使用和合并症治疗青少年的影响的研究 疾病，揭示了我们节点设计最新效率试验的能力，从而最大程度地发挥了潜力 CTN框架。我们相信NTN的结构和组织，及其承诺和高度 经验丰富的研究人员，补充并扩展了CTN的工作。