Optics Instrumentation for Advanced Ophthalmic Imaging

用于高级眼科成像的光学仪器

• 批准号: 7037410
• 负责人: DAVID R WILLIAMS
• 金额: $ 194.08万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7037410
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; confocal scanning microscopy; cooperative study; dogs; eye disorder diagnosis; eye surgery; human subject; imaging /visualization /scanning; laboratory rat; noninvasive diagnosis; optics; polarimetry; retina; retina disorder; single cell analysis; three dimensional imaging /topography; vision tests

DESCRIPTION (provided by applicant): The two goals of this Bioengineering Research Partnership are (1) to design and construct a new generation of instruments for noninvasive imaging of the mammalian retina with 3-D resolution superior to existing technology and capable of resolving single cells in vivo. (2) to explore the value of this technology through application to human retinal disease and retinal surgery. These instruments will combine adaptive optics, a technology borrowed from astronomy that automatically corrects all the eye's aberrations, with confocal microscopy, a technology for optically sectioning the retina. The lead institution will be the University of Rochester, and partners include Lawrence Livermore National Laboratory, the Doheny Eye Institute at USC, the University of Houston, the University of California at Berkeley, and the Schepens Eye Research Institute. By the end of year 1, a device will be operational at each of four clinical sites: USC, Rochester, Houston, and Schepens. In years 2-5, these devices will provide high resolution imaging of neovascularization in age related macular degeneration and diabetic retinopathy, photoreceptors in retinal degenerative disease such as retinitis pigmentosa, ganglion cell bodies in glaucoma, individual retinal pigment epithelial cells, and blood flow in the smallest retinal capilliaries. In year 3, a new surgical microscope equipped with adaptive optics will be constructed by LLNL. Retinal surgeons at USC will evaluate this device in years 4-5. Based on its experience with earlier instruments, the BRP will design and build a sixth instrument in year 4 that will be portable, compact, and user friendly. This device will be available to investigators outside the BRP. The BRP brings together optical engineers, basic vision scientists, and clinical vision researchers. This will allow engineers to design instrumentation informed by the specific needs of clinical research, allowing them to translate adaptive optics technology directly into clinical application. LLNL brings to the partnership expertise in optical engineering and adaptive optics from the fields of astronomy and laser fusion. Rochester and Houston will contribute experience in adaptive optics applied to retinal imaging. Rochester first applied adaptive optics to high resolution retinal imaging and Houston has recently demonstrated a prototype adaptive optics system that is the precursor for the devices proposed here. Schepens brings international leadership in scanning laser ophthalmoscopy. UC Berkeley provides expertise in the study of retinal degenerative diseases. USC, with its innovative approaches to retinal disease and retinal surgery, will join Rochester, Houston, and Schepens in providing clinical sites for the evaluation of confocal adaptive optics technology.

描述（由申请人提供）：这种生物工程研究合作伙伴关系的两个目标是（1）设计和构建新一代的哺乳动物视觉成像的新一代工具，其具有3-D分辨率优于现有技术，并且能够在体内解决单个细胞。 （2）通过应用人类视网膜疾病和视网膜手术来探索该技术的价值。 这些仪器将结合自适应光学器件，这是一种从天文学借来的技术，可以自动纠正所有眼睛的畸变，并与共聚焦显微镜，这是一种用于光学分割视网膜的技术。首席机构将是罗切斯特大学（University of Rochester），合作伙伴包括劳伦斯·利弗莫尔（Lawrence Livermore）国家实验室，南加州大学的多尼眼科研究所，休斯顿大学，加利福尼亚大学伯克利分校和Schepens Eye Research Institute。 到第1年底，该设备将在四个临床站点中的每个站点运行：USC，Rochester，Houston和Schepens。 在2 - 5年中，这些设备将提供与年龄相关的黄斑变性和糖尿病性视网膜病的新血管化的高分辨率成像，视网膜退化性疾病中的光感受器，例如视网膜炎色素，神经节细胞，金糖瘤中的神经节细胞体，单个视网膜色素细胞，单个小型上皮细胞以及小型视网膜化的血液流动。 在第3年，LLNL将构建配备自适应光学器件的新型外科显微镜。 南加州大学的视网膜外科医生将在4 - 5年内评估该设备。 根据其在早期仪器的经验，BRP将在4年级设计和构建第六次乐器，该乐器将是便携式，紧凑且用户友好的。 该设备将适用于BRP以外的调查人员。 BRP汇集了光学工程师，基本视觉科学家和临床视觉研究人员。 这将使工程师可以设计临床研究特定需求的仪器，从而使他们可以将自适应光学技术直接转化为临床应用。 LLNL带来了来自天文学和激光融合领域的光学工程和自适应光学方面的合作伙伴专业知识。 罗切斯特（Rochester）和休斯顿（Houston）将在用于视网膜成像的自适应光学方面提供经验。 罗切斯特（Rochester）首先将自适应光学元素应用于高分辨率视网膜成像，休斯顿最近展示了一种原型自适应光学系统，该系统是此处提出的设备的前体。 Schepens在扫描激光眼镜检查方面具有国际领导。 加州大学伯克利分校在视网膜退行性疾病研究方面提供了专业知识。南加州大学及其对视网膜疾病和视网膜手术的创新方法将与罗切斯特，休斯顿和Schepens一起提供临床地点，以评估共聚焦自适应光学技术。