Optics Instrumentation for Advanced Ophthalmic Imaging

用于高级眼科成像的光学仪器

• 批准号: 7037410
• 负责人: DAVID R WILLIAMS
• 金额: $ 194.08万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-03-01 至 2008-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7037410
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; clinical research; confocal scanning microscopy; cooperative study; dogs; eye disorder diagnosis; eye surgery; human subject; imaging /visualization /scanning; laboratory rat; noninvasive diagnosis; optics; polarimetry; retina; retina disorder; single cell analysis; three dimensional imaging /topography; vision tests

DESCRIPTION (provided by applicant): The two goals of this Bioengineering Research Partnership are (1) to design and construct a new generation of instruments for noninvasive imaging of the mammalian retina with 3-D resolution superior to existing technology and capable of resolving single cells in vivo. (2) to explore the value of this technology through application to human retinal disease and retinal surgery. These instruments will combine adaptive optics, a technology borrowed from astronomy that automatically corrects all the eye's aberrations, with confocal microscopy, a technology for optically sectioning the retina. The lead institution will be the University of Rochester, and partners include Lawrence Livermore National Laboratory, the Doheny Eye Institute at USC, the University of Houston, the University of California at Berkeley, and the Schepens Eye Research Institute. By the end of year 1, a device will be operational at each of four clinical sites: USC, Rochester, Houston, and Schepens. In years 2-5, these devices will provide high resolution imaging of neovascularization in age related macular degeneration and diabetic retinopathy, photoreceptors in retinal degenerative disease such as retinitis pigmentosa, ganglion cell bodies in glaucoma, individual retinal pigment epithelial cells, and blood flow in the smallest retinal capilliaries. In year 3, a new surgical microscope equipped with adaptive optics will be constructed by LLNL. Retinal surgeons at USC will evaluate this device in years 4-5. Based on its experience with earlier instruments, the BRP will design and build a sixth instrument in year 4 that will be portable, compact, and user friendly. This device will be available to investigators outside the BRP. The BRP brings together optical engineers, basic vision scientists, and clinical vision researchers. This will allow engineers to design instrumentation informed by the specific needs of clinical research, allowing them to translate adaptive optics technology directly into clinical application. LLNL brings to the partnership expertise in optical engineering and adaptive optics from the fields of astronomy and laser fusion. Rochester and Houston will contribute experience in adaptive optics applied to retinal imaging. Rochester first applied adaptive optics to high resolution retinal imaging and Houston has recently demonstrated a prototype adaptive optics system that is the precursor for the devices proposed here. Schepens brings international leadership in scanning laser ophthalmoscopy. UC Berkeley provides expertise in the study of retinal degenerative diseases. USC, with its innovative approaches to retinal disease and retinal surgery, will join Rochester, Houston, and Schepens in providing clinical sites for the evaluation of confocal adaptive optics technology.

描述（由申请人提供）：该生物工程研究合作伙伴关系的两个目标是（1）设计和构建新一代哺乳动物视网膜无创成像仪器，其 3D 分辨率优于现有技术，并且能够解析单细胞体内。 (2)通过应用于人类视网膜疾病和视网膜手术来探索该技术的价值。 这些仪器将结合自适应光学技术（一种借用自天文学的技术，自动校正所有眼睛的像差）和共焦显微镜（一种对视网膜进行光学切片的技术）。牵头机构将是罗彻斯特大学，合作伙伴包括劳伦斯利弗莫尔国家实验室、南加州大学多尼眼科研究所、休斯顿大学、加州大学伯克利分校和谢彭斯眼科研究所。 到第一年年底，设备将在四个临床中心运行：南加州大学、罗切斯特、休斯顿和谢彭斯。 在第 2-5 年，这些设备将为年龄相关性黄斑变性和糖尿病视网膜病变中的新生血管、视网膜退行性疾病（例如色素性视网膜炎）中的光感受器、青光眼中的神经节细胞体、单个视网膜色素上皮细胞以及视网膜中的血流提供高分辨率成像。最小的视网膜毛细血管。 第三年，LLNL 将建造一台配备自适应光学器件的新型手术显微镜。 南加州大学的视网膜外科医生将在 4-5 年内评估该设备。 根据其早期仪器的经验，BRP 将在第四年设计和制造第六台仪器，该仪器将是便携式、紧凑且用户友好的。 该设备可供 BRP 之外的调查人员使用。 BRP 汇集了光学工程师、基础视觉科学家和临床视觉研究人员。 这将使工程师能够根据临床研究的具体需求来设计仪器，从而使他们能够将自适应光学技术直接转化为临床应用。 LLNL 为合作伙伴带来了天文学和激光聚变领域的光学工程和自适应光学专业知识。 罗切斯特和休斯顿将贡献应用于视网膜成像的自适应光学的经验。 罗切斯特首先将自适应光学应用于高分辨率视网膜成像，休斯顿最近展示了一个原型自适应光学系统，该系统是此处提出的设备的前身。 Schepens 带来了扫描激光检眼镜领域的国际领先地位。 加州大学伯克利分校提供视网膜退行性疾病研究方面的专业知识。南加州大学凭借其在视网膜疾病和视网膜手术方面的创新方法，将与罗切斯特、休斯顿和谢彭斯一起，为共焦自适应光学技术的评估提供临床场所。