High Resolution Ultrasound Resource for Molecular Imaging Center

分子影像中心高分辨率超声资源

• 批准号: 7215090
• 负责人: Peter Stephen Conti
• 金额: $ 36.2万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-05-01 至 2008-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7215090
• 关键词: Anatomy; Animal Experimentation; Animal Model; Animals; Area; Automobile Driving; Award; Biochemistry; Biological Assay; Biomedical Engineering; Biopsy; Blood; Cardiac; Clinical; Complement; Coupled; Depth; Development; Developmental Process; Devices; Discipline of Nuclear Medicine; Disease; Engineering; Evaluation; Frequencies; Funding; Grant; Heart Diseases; Histopathology; Housing; Image; Imagery; Implant; Interdisciplinary Study; Invasive; Investigation; Laboratories; Laboratory Animals; Left Ventricular Ejection Fraction; Magnetic Resonance; Malignant Neoplasms; Measurement; Medical Imaging; Medicine; Microbubbles; Modality; Modeling; Molecular; Molecular Biology; Molecular Target; Monitor; National Center for Research Resources; Nonionizing Radiation; Operative Surgical Procedures; Organ; Pathology; Pharmacologic Substance; Physiological; Positron-Emission Tomography; Productivity; Public Health; Request for Proposals; Research Personnel; Resolution; Resources; Science; System; Technology; Therapeutic; Time; Tissues; Transducers; Transgenic Organisms; Ultrasonography; Vascular blood supply; Work; implantation; improved; in vivo; instrument; instrumentation; miniaturize; molecular imaging; mouse model; optical imaging; response; size; tumor; tumor growth

DESCRIPTION (provided by applicant): Recent advances in the instrumentation for medical imaging have produced miniaturized versions of x-ray, radionuclear and magnetic resonance scanners for studies in small laboratory animals. This, coupled with increasingly sophisticated transgenic mouse models, is driving a revolution in the investigation of disease and developmental processes in vivo at the whole-animal level. This proposal requests funding for a high-resolution ultrasound device to facilitate and improve interdisciplinary research in small animals in the areas of cancer and cardiac disease. High-frequency ultrasound is a newly emerging modality with great potential for use in small animal models. By increasing transducer frequencies, engineers have been able to achieve resolution-to-subject size ratios similar to those of clinical ultrasound imaging. As a result, anatomical and physiological (e.g., blood velocity) visualization and measurement capabilities are now fully available for use in small animals. Furthermore, recent development of microbubble technology has provided a very effective means of intravascular contrast enhancement and is being extended to molecular targeting, which could have a major impact on therapeutic delivery. During the last several years, a Molecular Imaging Center has been established at USC with support from an NIH/NCI P20 planning grant. The requested ultrasound scanner will be housed and operated in the Center's Molecular Imaging Laboratory, where it will complement other shared-use devices purchased with previous awards from the NCRR, including small-animal PET, CT and optical imaging systems. . Ultrasound would supplement our existing small-animal imaging capabilities with a non-ionizing radiation modality that would give us real-time, non-invasive anatomic imaging. High- frequency ultrasound imaging would greatly facilitate our use of orthotopic tumor models by allowing image-guided implantation in deep-lying organs and tissues. Other applications in small animal research will include: serial monitoring of tumor growth and tumor response to treatment; image-guided serial biopsy of tumors and implanted organs for ex vivo histopathology and molecular assay; serial assessment of tumor and organ blood supply, as well as evaluation of cardiac function, including left ventricular ejection fraction The requested ultrasound scanner will be used by investigators in the fields of radiology/nuclear medicine, surgery, pathology, biochemistry/molecular biology, pharmaceutical sciences, and biomedical engineering. Addition of the requested instrument will increase the productivity of assembled PHS-funded investigators who are working in various areas of medicine. The discoveries and advancements made by these investigators will ultimately have a direct positive impact on public health.

描述（由申请人提供）：医学成像仪器的最新进展生产了小型实验室动物研究的X射线，放射性和磁共振扫描仪的微型版本。这与越来越复杂的转基因小鼠模型相结合，正在整个动物水平的体内研究疾病和发育过程的一场革命。该提案要求为高分辨率超声设备提供资金，以促进和改善癌症和心脏病领域中小动物的跨学科研究。高频超声是一种新出现的方式，具有在小动物模型中使用的巨大潜力。通过增加换能器频率，工程师已经能够达到与临床超声成像相似的分辨率对象大小比率。结果，解剖学和生理（例如，血液速度）的可视化和测量能力现已完全可用于小动物。此外，微泡技术的最新发展提供了一种非常有效的血管内对比度增强的手段，并将其扩展到分子靶向，这可能会对治疗递送产生重大影响。在过去的几年中，在NIH/NCI P20计划补助金的支持下，在USC建立了一个分子成像中心。所需的超声扫描仪将在该中心的分子成像实验室中容纳并操作，在那里它将补充来自NCRR先前奖励的其他共享使用设备，包括小动物PET，CT，CT和光学成像系统。 。超声将以非电离辐射方式来补充我们现有的小动物成像功能，从而为我们提供实时，无创的解剖成像。高频超声成像将通过允许在深层器官和组织中进行图像引导的植入来极大地促进我们对原位肿瘤模型的使用。小动物研究中的其他应用包括：肿瘤生长的串行监测和肿瘤对治疗的反应；肿瘤和植入器官的图像引导的串行活检，用于体内组织病理学和分子测定；肿瘤和器官血液供应的系列评估以及心脏功能的评估，包括左心室射血分数，请求的超声扫描仪将由放射学/核医学，手术，病理学，生物化学/分子生物学，药物生物学，药物生物学，药物生物学，药物生物学，药物学，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，药物，制药，药物科学和生物医学工程。加入要求的工具将提高在各个医学领域工作的组装PHS资助的调查人员的生产率。这些调查人员的发现和进步最终将对公共卫生产生直接的积极影响。