Micro Computerized Tomography Imaging System

微型计算机断层扫描成像系统

• 批准号: 6731469
• 负责人: Peter Stephen Conti
• 金额: $ 37.83万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-05-15 至 2007-12-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6731469
• 关键词: X ray; bioimaging /biomedical imaging; biomedical equipment purchase; bone imaging /visualization /scanning; miniature biomedical equipment; tomography

DESCRIPTION (provided by applicant):Recent engineering advances in the instrumentation for medical imaging have produced miniaturized versions of x-ray, radionuclear and magnetic resonance scanners for studies in small laboratory animals. This, coupled with increasingly sophisticated, transgenic mouse models, is driving a revolution in the investigation of disease and developmental processes in vivo at the whole-animal level. This interdisciplinary proposal requests funding for a small-animal x-ray computed tomography scanner ("microCT"). The users are in the fields of radiology/nuclear medicine, medicine, pathology, biochemistry/molecular biology, orthopedic surgery, thoracic surgery, oncology and dentistry. The projects relate to bone development and osteoporosis, as well as to chemo- and antiangiognesis therapy of cancer. Applications of the proposed microCT scanner will include anatomic imaging for correlation with functional images from in vivo, small-animal PET and optical imagers; serial monitoring of metastatic tumor development in animal models; serial, in vivo, quantitative monitoring of normal and pathologic bone development and the effects of diet and genetic alteration on bone growth in transgenic murine models; and ultra-high resolution, in vitro, quantitative imaging of bone specimens in relation to bone development and response to diet and genetic modifications. During the last several years, a Molecular Imaging Center has been established at USC with support from an NIH/ NCIP20 planning grant. The requested microCT scanner will be housed and operated in Center's Molecular Imaging Laboratory, where it will complement small-animal PET and optical imaging systems purchased with previous grants from the NCRR. The particular microCT unit requested is well suited for both the in vitro and in vivo applications presented by the users, viz., it provides ultra-high (10 fm) spatial resolution and sophisticated analysis software for bone studies, acceptable radiation dosage for serial scanning applications in living animals, physiologic gating capability for high resolution in vivo scanning and large bore to accommodate the range of animal species used for micro PET studies. Addition of the requested instrument will greatly enhance the information provided by the existing small-animal molecular imaging facility as well as increase the productivity of assembled PHs-funded investigators at USC and Loma Linda University who are working in the areas of cancer and bone development/disease.

描述（由申请人提供）：医学成像仪器的最新工程进展已经生产出了用于小型实验动物研究的小型化版本的 X 射线、放射性核和磁共振扫描仪。再加上日益复杂的转基因小鼠模型，正在推动整个动物水平的体内疾病和发育过程研究的一场革命。这项跨学科提案要求资助小型动物 X 射线计算机断层扫描仪（“microCT”）。用户遍及放射学/核医学、医学、病理学、生物化学/分子生物学、骨科、胸外科、肿瘤学和牙科等领域。这些项目涉及骨骼发育和骨质疏松症，以及癌症的化疗和抗血管生成治疗。所提议的 microCT 扫描仪的应用将包括与体内、小动物 PET 和光学成像仪的功能图像相关的解剖成像；对动物模型中转移性肿瘤发展的连续监测；对转基因小鼠模型中正常和病理性骨骼发育以及饮食和遗传改变对骨骼生长的影响进行连续体内定量监测；骨样本的超高分辨率体外定量成像与骨骼发育以及对饮食和基因修饰的反应有关。过去几年，在 NIH/NCIP20 规划拨款的支持下，南加州大学建立了分子成像中心。所要求的 microCT 扫描仪将在中心的分子成像实验室安置和操作，该实验室将补充用 NCRR 先前拨款购买的小动物 PET 和光学成像系统。所需的特定 microCT 设备非常适合用户提出的体外和体内应用，即，它为骨骼研究提供超高 (10 fm) 空间分辨率和复杂的分析软件，以及用于连续扫描的可接受的辐射剂量其在活体动物中的应用、用于高分辨率体内扫描的生理门控能力以及适应用于显微 PET 研究的动物物种范围的大孔径。添加所需的仪器将大大增强现有小动物分子成像设施提供的信息，并提高南加州大学和洛马琳达大学由 PH 资助的癌症和骨骼发育领域研究人员的生产力/疾病。