Digital X-Ray Device for Molecular Imaging Center

分子影像中心数字X射线装置

• 批准号: 7795619
• 负责人: Peter Stephen Conti
• 金额: $ 13.48万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-07-01 至 2011-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7795619
• 关键词: Animal Experimentation; Animal Experiments; Animals; Area; Assimilations; Automobile Driving; Award; Biochemistry; Bone Density; Clinical Research; Complement; Computer software; Coupled; Dentistry; Developmental Process; Devices; Digital Radiography; Digital X-Ray; Disease; Funding; Housing; Image; In Vitro; Institutes; Interdisciplinary Study; Investigation; Laboratories; Laboratory Animals; Magnetic Resonance; Medical Imaging; Medicine; Molecular Biology; National Center for Research Resources; Operative Surgical Procedures; Optics; Oryctolagus cuniculus; Pathology; Positron-Emission Tomography; Productivity; Public Health; Request for Proposals; Research Personnel; Resolution; Sampling; Specimen; Speed; System; Tissues; Transgenic Mice; Translating; United States National Institutes of Health; Vendor; Work; digital; improved; in vivo; instrument; instrumentation; miniaturize; molecular imaging; mouse model; operation; optical imaging; portability; public health relevance

DESCRIPTION (provided by applicant): Recent advances in the instrumentation for medical imaging have produced miniaturized versions of x-ray, optical, radionuclear and magnetic resonance scanners for studies in small laboratory animals. This, coupled with increasingly sophisticated transgenic mouse models, is driving a revolution in the investigation of disease and developmental processes in vivo at the whole-animal level. This proposal requests funding for a high-throughput, high-resolution digital x-ray device to facilitate and improve interdisciplinary research using small animals. During the last several years, a Molecular Imaging Center has been established at USC with support over the last year from multiple awards from the NCRR and other NIH Institutes. The requested device will be housed and operated in the Center's Molecular Imaging Laboratory, where it will complement other shared-use devices purchased with previous awards from the NCRR, including small-animal PET, CT and optical imaging systems. The instrument chosen has numerous features conducive to efficient operation, including, digital acquisition and DICOM compatibility (essential for assimilation into our developing animals PACS system), accommodation of both small and large (eg. rabbit) animal examinations, rapid throughput, portability within the laboratory (mobile cart), and analytical software for bone density assessment (to be released by vendor 4/09). The requested digital x-ray device will be used by investigators in the fields of medicine, surgery, pathology, biochemistry/molecular biology, and dentistry. Addition of the requested instrument will increase the productivity of assembled PHS-funded investigators who are working in various areas of medicine. The discoveries and advancements made by these investigators will ultimately have a direct positive impact on public health. PUBLIC HEALTH RELEVANCE: We are requesting a digital radiography system for quantitative 2D x-ray imaging of small animals and excised tissue specimens. Because of the diverse needs of our user group, an imaging unit that offers high speed imaging, a wide range of image resolution for in vivo imaging in non-terminal animal experiments, and appropriate capabilities for high resolution imaging of in vitro samples is required. Animal research conducted with this instrument may translate into clinical research trials, with great public health implications.

描述（由申请人提供）：医学成像仪器的最新进展生产了小型实验室动物研究的X射线，光学，放射性和磁共振扫描仪的微型版本。这与越来越复杂的转基因小鼠模型相结合，正在整个动物水平的体内研究疾病和发育过程的一场革命。该提案要求资助高通量，高分辨率的数字X射线设备，以促进和改善使用小动物的跨学科研究。在过去的几年中，在过去一年中，由NCRR和其他NIH研究所的多个奖项获得了分子成像中心的支持。所请求的设备将在该中心的分子成像实验室中容纳并操作，它将与NCRR先前奖励购买的其他共享使用设备进行补充，包括小动物PET，CT，CT和光学成像系统。所选的仪器具有许多有利于高效运行的功能，包括数字习得和DICOM兼容性（对于我们发育中的动物PACS系统中的吸收至关重要），小大型（例如兔子）动物检查，快速吞噬性，可容纳性，可容纳性，可容纳性，实验室（移动推车）和用于骨密度评估的分析软件（供应商4/09发布）。要求的数字X射线设备将由医学，手术，病理，生物化学/分子生物学和牙科领域的研究人员使用。加入要求的工具将提高在各个医学领域工作的组装PHS资助的调查人员的生产率。这些调查人员的发现和进步最终将对公共卫生产生直接的积极影响。 公共卫生相关性：我们要求使用数字X射线照相系统，用于定量的小动物和切除组织样品的2D X射线成像。由于我们的用户组的各种需求，这是一个提供高速成像的成像单元，因此需要在非末端动物实验中进行体内成像的广泛图像分辨率，并且需要适当的体外样品成像功能。使用该工具进行的动物研究可能会转化为临床研究试验，具有很大的公共卫生影响。