Small Animal Photoacoustic Imaging Unit: Integrating Optical Imaging with High Fr

小动物光声成像装置：光学成像与高频相结合

• 批准号: 8640794
• 负责人: Peter Stephen Conti
• 金额: $ 59.9万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2014
• 资助国家: 美国
• 起止时间: 2014-06-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8640794
• 关键词: Acoustics; Alcohols; Animal Disease Models; Animals; Brain imaging; Cardiology; Complement; Computer software; Coupled; Data; Dentistry; Development; Developmental Biology; Developmental Process; Discipline; Disease; Engineering; Funding; Generations; Genetic Medicine; Growth; Image; Investigation; Lasers; Light; Liver diseases; Mechanics; Medicine; Minor; Modality; Neurosciences; Optical Methods; Optics; Pathology; Penetration; Pharmacologic Substance; Pharmacy facility; Physiologic pulse; Process; Research; Research Support; Resolution; Science; Signal Transduction; Structure; System; Tissue Expansion; Tissues; Transducers; Ultrasonic wave; Ultrasonography; United States National Institutes of Health; Work; absorption; base; drug induced liver disease; human disease; imaging modality; in vivo; molecular imaging; mouse model; nanoparticle; oncology; optical imaging; photoacoustic imaging; sound

DESCRIPTION (provided by applicant): The need to study dynamic processes in intact small animal models of disease has stimulated the development of high resolution multi-modality imaging methods that provide not only functional but also anatomical information. Photoacoustic imaging for biomedical applications has shown tremendous growth in the last decade due to its applicability to a spectrum of research topics such as oncology, brain imaging and nanoparticle research. Based on the concept of "light in and sound out", photoacoustic imaging capitalizes on the rapid thermoelastic expansion of tissue upon absorption of pulsed laser energy. This thermoelastic expansion results in the generation of a wide band ultrasound wave which then can be detected with a transducer that converts the mechanical acoustic wave into electrical signals. When coupled with ultrasound, photoacoustic imaging can simultaneously provide anatomical and functional data. Photoacoutstic imaging occupies a void in molecular imaging by providing high optical contrast images at microscale resolution and at a reasonable penetration depth, therefore light absorbing structures deep inside tissues can be detected and visualized with resolutions far superior to pure optical methods. We are requesting funds to purchase a high-resolution photoacoustic system, Vevo LAZR (VisualSonics, Inc.), equipped with optical and acoustic components and analysis software. The addition of this photoacoustic system will strengthen both ongoing work in oncology, pharmaceutical sciences, engineering, neurosciences, and genetic medicine by current users of the USC Molecular Imaging Center, as well as greatly enhance the ability of the Center to support new research in liver disease, cardiology, pathology, developmental biology and nanoparticle research. We have gathered 14 NIH funded users (10 major users and 4 minor users) with research disciplines in alcohol/drug induced liver disease, engineering, dentistry, cardiology, oncology and pharmacy to support our current S10 application. This system, coupled with increasingly sophisticated mouse models that recapitulate human disease pathology, is fueling a revolution in the investigation of disease and normal developmental processes in vivo. The acquisition of the photoacoustics system will complement and support the research revolution towards personalized medicine.

描述（由申请人提供）：在完整的小动物模型中研究动态过程的需求刺激了高分辨率多模式成像方法的发展，这些方法不仅提供功能性，而且提供解剖学信息。用于生物医学应用的光声成像在过去十年中显示出巨大的增长，因为它适用于肿瘤学，脑成像和纳米粒子研究等一系列研究主题。基于“光入并发出声音”的概念，光声成像在吸收脉冲激光能量后，将组织的快速热弹性扩展。这种热弹性膨胀导致宽带超声波的产生，然后可以用传感器检测到将机械声波转换为电信号的传感器。与超声结合时，光声成像可以同时提供解剖和功能数据。 PhotoAcoutstic成像通过在微观分辨率和合理的穿透深度下提供高光学对比度图像，从而占据了分子成像中的空隙，因此，可以检测到深度吸收内部组织内部组织内部的结构，并以远优于纯粹的光学方法来检测和可视化。我们要求资金购买高分辨率光声系统Vevo Lazr（Visualsonics，Inc。），配备了光学和声学组件和分析软件。这种光声系统的添加将加强肿瘤学，药物科学，工程，神经科学和遗传医学的正在进行的工作，而USC分子成像中心的现任用户也大大增强了该中心支持肝脏疾病，心脏病学，病理学，病理，发育生物学和纳米学研究的新研究的能力。我们收集了14位NIH资助的用户（10位主要用户和4名未成年人），其中包括酒精/药物诱导的肝脏疾病，工程，牙科，心脏病学，肿瘤学和药房的研究学科，以支持我们当前的S10应用。该系统以及越来越复杂的小鼠模型概括了人类疾病病理学，在体内研究了疾病和正常发育过程的革命。对光声系统的获取将补充并支持对个性化医学的研究革命。