Treatment of Complex Patients: Emphasis on Nicotine

复杂患者的治疗：强调尼古丁

基本信息

批准号：
7242599
负责人：
Sharon M. Hall
金额：
$ 11.37万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-08-20 至 2008-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7242599
关键词：
Abstinence Accident and Emergency department Acute Address Adherence Adult Adverse effects Advertisements Advisory Committees Age Age-Years Aging Agreement Air Alcohol consumption Ambulatory Care Facilities American American Lung Association Anabasine Anger Antidepressive Agents Anxiety Applications Grants Area Attention Award Beck depression inventory Beds Behavior Therapy Behavioral Behavioral Model Belief Biological Assay Biostatistics Core Blood Pressure Blood Pressure Monitors Body Weight Changes Boxing Budgets Build-it Bupropion Bupropion/Nicotine California Caloric Restriction Carbon Monoxide Caring Case Management Case Manager Case Study Caucasians Caucasoid Race Cells Cessation Research Characteristics Chronic Chronic Disease Cigarette Cigarette Smoker Cities Client Clinic Clinical Clinical Trials Code Cognitive Collaborations Combined Modality Therapy Commit Communicable Diseases Communication Communities Comorbidity Complex Condition Conflict (Psychology)Consultations Controlled Clinical Trials Cost Control Cost Effectiveness Analysis Cotinine Counseling Data Data Analyses Data Collection Data Set Databases Decision Making Dependence Depressed mood Depressive disorder Development Diagnosis Direct Costs Disease Dose Double-Blind Method Drops Drug Abuse Treatment Services Drug Addiction Drug abuse Drug usage Economics Educational Materials Effectiveness Effectiveness of Interventions Elderly Electronics Elements Emergency Situation Employment Status Enrollment Ensure Equation Equilibrium Equipment and supply inventories Estrogens Evaluation Event Exercise Expert Systems Faculty Family Feedback Frail Elderly Funding Future Gender General Population Geriatric Psychiatry Goals Grant Gray unit of radiation dose Group Therapy Guidelines HIV HIV Seropositivity Health Health Benefit Health Care Costs Health Personnel Health Services Health Services Accessibility Health Services Research Health Status Health system Healthcare Healthcare Systems Hospitals Hour Human Incentives Incidence Income Individual Injecting drug user Institutes Instruction Intake Intervention Intervention Studies Interview Lead Leadership Learning Left Legal Legal Status Length Letters Life Literature Lobbying Logistic Regressions Longitudinal Studies Mails Maintenance Manuals Manufacturer Name Measurement Measures Medical Medical Staff Medication Management Mental Depression Mental Health Mental disorders Mentally Ill Persons Mentors Methadone Methodology Methods Minimal Contact Treatment Modality Modeling Moderate Exercise Modification Monitor Mood Disorders Moods Motivation Movement National Institute of Drug Abuse Nature Newspapers Nicotine Nicotine Dependence Nortriptyline Not Otherwise Specified Numbers Nursing Homes Opiates Opioid Other Therapy Outcome Outcome Measure Outpatients Pamphlets Paper Participant Pathway interactions Patient Self-Report Patients Pattern Perception Personal Satisfaction Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Phase Physical Function Physical activity Pilot Projects Placebo Control Placebos Placement Population Practice Guidelines Preparation Prevalence Prevention intervention Prevention therapy Principal Investigator Probability Procedures Process Production Professional counselor Protocols documentation Provider Psyche structure Psychiatric Diagnosis Psychiatric therapeutic procedure Psychiatrist Psychological reinforcement Psychometrics Psychosocial Assessment and Care Psychotherapy Public Health Public Sector Published Comment Published Practice Guidelines Purpose Questionnaires Randomized Randomized Clinical Trials Rate Readiness Recommendation Recording of previous events Recruitment Activity Recurrent disease Recycling Regression Analysis Relapse Reporting Research Research Design Research Personnel Research Project Grants Research Training Resources Restart Retirement Risk SF-36 Sample Size Sampling San Francisco Schedule Scientist Score Self-Administered Series Serum Services Severities Sex Functioning Shapes Site Smoke Smoker Smoking Smoking Behavior Smoking Cessation Intervention Smoking Status Social Functioning Social Network Social Work Social status Social support Source Staging Standards of Weights and Measures Statistical Methods Stratification Stress Study models Substance Use Disorder Substance abuse problem Suggestion Supervision Supported Employment Surgeon System TNFRSF5 gene Telephone Testing Therapeutic Thinking Time Titrations Tobacco smoking Today Training Training Programs Training Support Transportation Travel Treatment Efficacy Treatment outcome Treatment/Psychosocial Effects Universities Vision Visit Week Weight Gain Weight maintenance regimen Withdrawal Withdrawal Symptom Withholding Treatment Woman Work Writing Zyban addiction age group anatabine base behavior change blind care systems cigarette smoking clinical efficacy computerized concept contingency management coping cost cost effectiveness data management day deep breathing exercises demographics depressive symptoms design disorder later incidence prevention dissemination research disturbance in affect drug abstinence drug abuser drug of abuse dysphoria early /brief intervention /therapy expectation experience follow-up functional disability geriatric depression group counseling health care service utilization human PTCH2 protein improved indexing innovation instrument interest loss of function male medication compliance member men monitoring device mortality motivational enhancement therapy neglect nicotine gum nicotine patch nicotine replacement non-smoker non-smoking older women outreach pill post-doctoral training prevent programs psychologic psychosocial reinforced behavior research study response restraint self help sex skills smoking cessation smoking intervention social social group stressor substance abuser therapy design therapy development treatment program voucher wound

项目摘要

DESCRIPTION (provided by applicant): The overall goal of this K05 proposal is to support and extend my research in the treatment of drug abuse, especially nicotine dependence, to further my capacity to mentor junior scientists, to allow me to continue in scientific leadership and dissemination of research findings to the clinical community. My interests focus on the treatment of drug dependence, especially nicotine dependence as a chronic, relapsing disorder. I am also interested in comorbidities across drugs of abuse. I will complete two R01 grants that focus on extended treatment of cigarette smoking: (1) a study of extended behavioral relapse prevention and bupropion treatment for chronic smokers; (2) a study of extended, age-specific relapse prevention and nicotine replacement treatment for older smokers. I will continue to direct a P50 center grant that focuses on Blended Treatments for Complex Patients. My center component, Treatment of Comorbid Smokers, studies an innovative intervention for depressed smokers in a psychiatric outpatient clinic, and determines the efficacy and cost-effectiveness of the intervention. I will also complete a pilot study funded by the state of California on interventions for frail elderly smokers. In later years of this award, I will develop and propose studies that are logical extensions of ongoing work. I will continue to direct a postdoctoral training program in drug abuse treatment and services research, and participate in other research training programs, and will disseminate results to the clinical community. The award will allow me time and give me support to pursue research projects that further current work in smoking, depression, antidepressants, and psychotherapy, to spend appropriate time mentoring junior faculty, to continue my involvement in center grants and other collaborative mechanisms, and to refine my methodological skills and disseminate research findings to the professional community.

描述（由申请人提供）：该K05提案的总体目标是支持和扩展我在治疗药物滥用方面的研究，尤其是尼古丁依赖，以进一步指导我指导初级科学家的能力，以使我能够继续进行科学领导和将研究结果传播到临床上社区。我的兴趣集中在药物依赖性的治疗中，尤其是尼古丁依赖性作为一种慢性复发障碍。我也对跨虐待药物的合并症感兴趣。我将完成两项R01赠款，重点是扩展吸烟的治疗：（1）对长期吸烟者的延长行为复发预防和安非他酮治疗的研究；（2）对年龄较大吸烟者的扩展，特异性复发预防和尼古丁替代治疗的研究。我将继续指导P50中心拨款，该赠款重点介绍了复杂患者的混合治疗方法。我的中心成分，合并吸烟者的治疗，研究精神病学院门诊诊所中吸烟者的创新干预措施，并确定干预措施的疗效和成本效益。我还将完成一项由加利福尼亚州对脆弱的老年吸烟者干预的试点研究。在该奖项的后期，我将开发并提出研究，这些研究是正在进行的工作的逻辑扩展。我将继续指导一项有关药物滥用治疗和服务研究的博士后培训计划，并参与其他研究培训计划，并将结果传播给临床社区。该奖项将使我有时间并为我提供支持，以从事研究项目，以进一步在吸烟，抑郁症，抗抑郁药和心理治疗方面，花费适当的时间指导初级教师，继续我参与中心赠款和其他协作机制，以及完善我的方法学技能，并将研究结果传播给专业社区。