Treatment of Complex Patients: Emphasis on Nicotine

复杂患者的治疗：强调尼古丁

• 批准号: 8264225
• 负责人: Sharon M. Hall
• 金额: $ 11.37万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-20 至 2013-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8264225
• 关键词: Abstinence; Age; Ambulatory Care Facilities; Award; Back; Behavioral; Biography; Bupropion; Categories; Chronic; Cigarette; Clinical; Clinical Trials; Cocaine; Collaborations; Communities; Complex; Depressed mood; Disease; Drug Abuse Treatment Services; Drug abuse; Effectiveness of Interventions; Faculty; Fostering; Funding; Genetic; Goals; Grant; Health Care Costs; Health Services Research; Healthcare; Individual; Intervention; Leadership; Mental Health; Mentors; Nicotine; Nicotine Dependence; Opioid; Paper; Patients; Publishing; Recording of previous events; Recruitment Activity; Relapse; Research; Research Personnel; Research Training; Role; Scientist; Smoker; Smoking; TNFRSF5 gene; Target Populations; Technology; Testing; Tobacco Dependence; Training; Training Programs; Work; addiction; base; career; cost effectiveness; disorder later incidence prevention; follow-up; innovation; interest; nicotine replacement; post-doctoral training; programs; response

DESCRIPTION (provided by applicant): The goal of this competing renewal K05 proposal is to continue to support my research in the treatment of nicotine dependence, to further my capacity to mentor junior scientists and train postdoctoral scholars, to allow me to continue in scientific leadership through research center administration, and to disseminate research findings to the scientific and clinical community. Since this award was last submitted, I have published, in press, or under review 62 scientific papers. I completed a clinical trial (N=322) of an innovative intervention for depressed smokers in a psychiatric outpatient clinic, studying both smoking abstinence and its impact on mental health, and the cost-effectiveness of the intervention. As proposed, I am completing two major clinical trials: (1) a study of extended behavioral relapse prevention and bupropion treatment for chronic smokers (N=407); (2) a study of extended, age-specific relapse prevention and nicotine replacement treatment for older smokers (n=403). Extended treatment conditions in these two studies have produced biologically confirmed abstinence rates from 53 to 42% at one year. Of greatest importance, these rates do not change at two year follow-up; they remain at precisely the level observed at one year. I continued to direct a P50 center grant that focuses on Treatment of Complex Patients with an emphasis on nicotine. In addition, I have developed collaborations with other scientists, who are mostly my mentees. This work includes tobacco dependence treatment studies for targeted populations and for co-morbid smokers. In addition, I collaborate with other scientists of the genetics of bupropion response in smokers, and on the effects of reduced nicotine cigarettes. If this award is funded, I will continue my work on extended treatment, studying implementation in health care settings, and developing and testing technology based adaptations of it. I will continue my leadership role in the P50 grant and in the postdoctoral training grant, and will continue to collaborate with other faculty, especially junior faculty. I have a history of mentoring junior faculty that extends back well before the receipt of this award. I will also continue my mentoring role, and increase my mentoring of junior faculty, as new faculty are recruited, and the new departmental mentoring program is implemented and enhanced. Last, I will continue my work with individual postdoctoral trainees.

描述（由申请人提供）：该竞争性更新K05提案的目标是继续支持我在治疗尼古丁依赖方面的研究，以进一步指导初级科学家和培训博士后学者，以允许我继续进行科学领导力通过研究中心管理，并向科学和临床社区传播研究结果。由于该奖项是上次提交的，因此我在媒体或评论中发表了62篇科学论文。我完成了一项针对精神病患者诊所吸烟者的创新干预措施的临床试验（n = 322），研究了戒烟及其对心理健康的影响以及干预措施的成本效益。如建议，我正在完成两个主要的临床试验：（1）针对慢性吸烟者的延长行为复发和安非他酮治疗的研究（n = 407）； （2）对年龄较大吸烟者的扩展，特异性复发预防和尼古丁替代治疗的研究（n = 403）。这两项研究的扩展治疗条件已产生了一年的生物学确认的禁欲率从53％到42％。最重要的是，这些速率在两年后的随访中不会发生变化。他们确切地保持了一年的观察水平。我继续指导P50中心赠款，该赠款专注于对复杂患者的治疗，重点是尼古丁。此外，我还与其他科学家建立了合作，这些科学家主要是我的受训者。这项工作包括针对目标人群和共同吸烟者的烟草依赖治疗研究。此外，我还与其他科学家合作，讨论吸烟者中安非他酮反应的遗传学以及减少尼古丁香烟的影响。如果该奖项是资助的，我将继续进行扩展治疗，研究医疗保健环境中的实施以及开发和测试基于技术的改编的工作。我将继续在P50赠款和博士后培训补助金中继续领导职务，并将继续与其他教师，尤其是初级教师合作。我有指导初级教师的历史，该教师在收到该奖项之前就可以追溯到。我还将继续我的指导角色，并增加对初级教师的指导，因为招募了新的教职员工，并实施和增强了新的部门指导计划。最后，我将继续与个别的博士后学员一起工作。