Treatment of Complex Patients: Emphasis on Nicotine

复杂患者的治疗：强调尼古丁

基本信息

批准号：
7525009
负责人：
Sharon M. Hall
金额：
$ 11.37万
依托单位：
UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-08-20 至 2013-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7525009
关键词：
Abstinence Accident and Emergency department Acute Address Adherence Adult Adverse effects Advertisements Advisory Committees Age Age-Years Aging Agreement Air Alcohol consumption Ambulatory Care Facilities American American Lung Association Anabasine Anger Antidepressive Agents Anxiety Applications Grants Area Attention Award Back Beck depression inventory Beds Behavior Therapy Behavioral Behavioral Model Belief Biological Assay Biostatistics Core Blood Pressure Blood Pressure Monitors Body Weight Changes Boxing Budgets Build-it Bupropion Bupropion/Nicotine Caloric Restriction Carbon Monoxide Caring Case Management Case Manager Case Study Caucasians Caucasoid Race Cells Cessation Research Characteristics Chronic Chronic Disease Cigarette Cigarette Smoker Cities Client Clinic Clinical Clinical Trials Code Cognitive Collaborations Combined Modality Therapy Commit Communicable Diseases Communication Communities Comorbidity Complex Condition Conflict (Psychology)Consultations Controlled Clinical Trials Cost Control Cost Effectiveness Analysis Cotinine Counseling Data Data Analyses Data Collection Data Set Databases Decision Making Dependence Depressed mood Depressive disorder Development Diagnosis Direct Costs Disease Dose Double-Blind Method Drops Drug Abuse Treatment Services Drug abuse Drug usage Economics Educational Materials Effectiveness Effectiveness of Interventions Elderly Electronics Elements Emergency Situation Employment Status Enrollment Ensure Equation Equilibrium Equipment and supply inventories Estrogens Evaluation Event Exercise Expert Systems Faculty Family Feedback Frail Elderly Funding Future Gender General Population Genetic Geriatric Psychiatry Goals Grant Gray unit of radiation dose Group Therapy Guidelines HIV HIV Seropositivity Health Health Benefit Health Care Costs Health Personnel Health Services Health Services Accessibility Health Services Research Health Status Health system Healthcare Healthcare Systems Hospitals Hour Human Incentives Incidence Income Individual Injecting drug user Institutes Instruction Intake Intervention Intervention Studies Interview Lead Leadership Learning Left Legal Legal Status Length Letters Life Literature Lobbying Logistic Regressions Longitudinal Studies Mails Maintenance Manuals Manufacturer Name Measurement Measures Medical Medical Staff Medication Management Mental Depression Mental Health Mental disorders Mentally Ill Persons Mentors Methadone Methodology Methods Minimal Contact Treatment Modality Modeling Moderate Exercise Modification Monitor Mood Disorders Moods Motivation Movement National Institute of Drug Abuse Nature Newspapers Nicotine Nicotine Dependence Nortriptyline Not Otherwise Specified Numbers Nursing Homes Opiates Opioid Other Therapy Outcome Outcome Measure Outpatients Pamphlets Paper Participant Pathway interactions Patient Self-Report Patients Pattern Perception Personal Satisfaction Pharmaceutical Preparations Pharmacological Treatment Pharmacotherapy Phase Physical Function Physical activity Pilot Projects Placebo Control Placebos Placement Population Practice Guidelines Preparation Prevalence Prevention intervention Prevention therapy Principal Investigator Probability Procedures Process Production Professional counselor Protocols documentation Provider Psyche structure Psychiatric Diagnosis Psychiatric therapeutic procedure Psychiatrist Psychological reinforcement Psychometrics Psychosocial Assessment and Care Public Health Public Sector Published Comment Published Practice Guidelines Publishing Purpose Questionnaires Randomized Randomized Clinical Trials Rate Readiness Recommendation Recording of previous events Recruitment Activity Recurrent disease Recycling Regression Analysis Relapse Reporting Research Research Design Research Personnel Research Training Resources Restart Retirement Risk Role SF-36 Sample Size Sampling San Francisco Schedule Scientist Score Self-Administered Series Serum Services Severities Sex Functioning Shapes Site Smoke Smoker Smoking Smoking Behavior Smoking Cessation Intervention Smoking Status Social Functioning Social Network Social Work Social status Social support Source Staging Standards of Weights and Measures Statistical Methods Stratification Stress Study models Substance Use Disorder Substance abuse problem Suggestion Supervision Supported Employment Surgeon System TNFRSF5 gene Target Populations Technology Telephone Testing Therapeutic Thinking Time Titrations Tobacco Dependence Tobacco smoking Today Training Training Programs Training Support Transportation Travel Treatment Efficacy Treatment outcome Treatment/Psychosocial Effects Universities Vision Visit Week Weight Gain Weight maintenance regimen Withdrawal Withdrawal Symptom Withholding Treatment Woman Work Writing Zyban addiction age group aged anatabine base behavior change blind care systems cigarette smoking clinical efficacy computerized concept contingency management coping cost cost effectiveness data management day deep breathing exercises demographics depressive symptoms design disorder later incidence prevention dissemination research disturbance in affect drug abstinence drug abuser dysphoria early /brief intervention /therapy expectation experience follow-up functional disability geriatric depression group counseling health care service utilization human PTCH2 protein improved indexing innovation instrument interest loss of function male medication compliance member men monitoring device mortality motivational enhancement therapy neglect nicotine gum nicotine patch nicotine replacement non-smoker non-smoking older women outreach pill post-doctoral training prevent programs psychologic psychosocial reinforced behavior research study response restraint self help sex skills smoking cessation smoking intervention social social group stressor substance abuser therapy design therapy development treatment program voucher wound

项目摘要

DESCRIPTION (provided by applicant): The goal of this competing renewal K05 proposal is to continue to support my research in the treatment of nicotine dependence, to further my capacity to mentor junior scientists and train postdoctoral scholars, to allow me to continue in scientific leadership through research center administration, and to disseminate research findings to the scientific and clinical community. Since this award was last submitted, I have published, in press, or under review 62 scientific papers. I completed a clinical trial (N=322) of an innovative intervention for depressed smokers in a psychiatric outpatient clinic, studying both smoking abstinence and its impact on mental health, and the cost-effectiveness of the intervention. As proposed, I am completing two major clinical trials: (1) a study of extended behavioral relapse prevention and bupropion treatment for chronic smokers (N=407); (2) a study of extended, age-specific relapse prevention and nicotine replacement treatment for older smokers (n=403). Extended treatment conditions in these two studies have produced biologically confirmed abstinence rates from 53 to 42% at one year. Of greatest importance, these rates do not change at two year follow-up; they remain at precisely the level observed at one year. I continued to direct a P50 center grant that focuses on Treatment of Complex Patients with an emphasis on nicotine. In addition, I have developed collaborations with other scientists, who are mostly my mentees. This work includes tobacco dependence treatment studies for targeted populations and for co-morbid smokers. In addition, I collaborate with other scientists of the genetics of bupropion response in smokers, and on the effects of reduced nicotine cigarettes. If this award is funded, I will continue my work on extended treatment, studying implementation in health care settings, and developing and testing technology based adaptations of it. I will continue my leadership role in the P50 grant and in the postdoctoral training grant, and will continue to collaborate with other faculty, especially junior faculty. I have a history of mentoring junior faculty that extends back well before the receipt of this award. I will also continue my mentoring role, and increase my mentoring of junior faculty, as new faculty are recruited, and the new departmental mentoring program is implemented and enhanced. Last, I will continue my work with individual postdoctoral trainees.

描述（由申请人提供）：这项竞争性更新 K05 提案的目标是继续支持我在治疗尼古丁依赖方面的研究，提高我指导初级科学家和培训博士后学者的能力，使我能够继续担任科学领导职务通过研究中心管理，并向科学和临床界传播研究成果。自从上次提交该奖项以来，我已在报刊上发表或正在审阅 62 篇科学论文。我在精神病门诊完成了一项针对抑郁吸烟者的创新干预措施的临床试验 (N=322)，研究了戒烟及其对心理健康的影响，以及干预措施的成本效益。按照提议，我正在完成两项主要的临床试验：（1）针对长期吸烟者的长期行为复发预防和安非他酮治疗的研究（N=407）； (2) 针对老年吸烟者的长期、特定年龄复吸预防和尼古丁替代治疗的研究 (n=403)。这两项研究中的延长治疗条件已使一年内经生物学证实的戒断率从 53% 提高到 42%。最重要的是，这些比率在两年的随访中不会发生变化；它们准确地保持在一年时观察到的水平。我继续指导 P50 中心的一项资助，该资助的重点是复杂患者的治疗，重点是尼古丁。此外，我还与其他科学家开展了合作，他们大多是我的导师。这项工作包括针对目标人群和共病吸烟者的烟草依赖治疗研究。此外，我还与其他科学家合作研究吸烟者安非他酮反应的遗传学以及减少尼古丁香烟的影响。如果该奖项获得资助，我将继续从事延长治疗、研究医疗保健环境中的实施以及开发和测试基于技术的适应工作。我将继续在 P50 资助和博士后培训资助中发挥领导作用，并将继续与其他教师，特别是初级教师合作。我有指导初级教师的历史，可以追溯到获得该奖项之前。随着新教师的招募以及新的院系指导计划的实施和加强，我还将继续担任指导角色，并增加对初级教师的指导。最后，我将继续与个别博士后学员一起工作。