Benign Breast Disease: A New Frontier for Prevention

良性乳腺疾病：预防的新领域

基本信息

批准号：
7224862
负责人：
MARY Beryl DALY
金额：
$ 11.53万
依托单位：
FOX CHASE CANCER CENTER
依托单位国家：
美国
项目类别：
财政年份：
2005
资助国家：
美国
起止时间：
2005-03-01 至 2010-02-28
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7224862
关键词：
Award Awareness Basic Science Behavioral Sciences Benign Biological Assay Biological Markers Biology Biopsy Biopsy Specimen Breast Breast Cancer Prevention Breast Diseases Caring Categories Chemoprevention Clinical Clinical Management Clinical Protocols Collaborations Community Healthcare Counseling Decision Aid Decision Making Diagnosis Diagnostic Discrimination Disease Management Education Educational Status Epidemiologic Studies Family Fellowship Fostering Genetic Goals Health Health Promotion Hereditary Malignant Neoplasm Histopathology Human Genome Project Individual Intervention Lesion Malignant Neoplasms Malignant neoplasm of ovary Mammography Medical Oncology Mentors Molecular Molecular Medicine Nature Normal tissue morphology Outcome Pathologist Patients Population Population Sciences Prevention Prevention strategy Preventive Proteomics Protocols documentation Public Health Randomized Recording of previous events Research Research Infrastructure Research Personnel Research Project Grants Resources Risk Rotation Scientist Screening procedure Senior Scientist Award Series Standards of Weights and Measures Students Testing Therapeutic Time Tissues Training Translational Research Translations Uncertainty Underserved Population Woman Work base breast lesion cancer prevention cancer risk career coping disorder prevention frontier improved interest laser capture microdissection malignant breast neoplasm novel preference prognostic programs prospective psychologic stem theories tumor molecular fingerprint

项目摘要

DESCRIPTION (provided by applicant): For the past twenty years, I have been involved with the care of women with breast and ovarian cancer, and their families. During that time my research focus has gradually shifted from management of the disease to its prevention. This direction has been enhanced by the work of the Human Genome Project, which has made tremendous progress in advancing our understanding of the genetic basis of cancer, and by the increased awareness on the part of both the public and the health care community of the tremendous potential for disease prevention and control. Building on this framework, I have developed a nationally recognized research-based program, defined by familial cancer risk, in which to explore novel education and counseling interventions and prevention strategies. I have formed longstanding collaborations with colleagues in the basic sciences, population sciences and behavioral sciences to foster translational research. I have contributed to the training of scientists at many levels who are new to the field of cancer prevention and control. I represent one of a handful of investigators in the field of cancer prevention and control who combines theory-driven research initiatives with actual translation to the clinical setting. At this point in my career, the K05 award will allow me to extend these efforts to a growing and underserved population of women who are at increased risk for breast cancer because of a diagnosis of benign breast disease. In the new era of molecular medicine, this population provides an ideal opportunity to study early molecular signatures of cancer risk, to identify genetic modifiers of risk, and to tailor preventive options to the biology of the lesion. The award will also facilitate my efforts to formalize a novel clinical genetics training rotation within the medical oncology fellowship, and will afford more opportunities to mentor students at all levels of training.

描述（由申请人提供）：在过去的二十年里，我一直参与乳腺癌和卵巢癌女性及其家人的护理工作。在那段时间里，我的研究重点逐渐从疾病的治疗转向预防。人类基因组计划的工作加强了这一方向，该计划在增进我们对癌症遗传基础的理解方面取得了巨大进展，并且公众和医疗保健界对巨大癌症的认识不断提高。疾病预防和控制的潜力。在此框架的基础上，我制定了一项全国认可的基于研究的计划，以家族癌症风险为定义，探索新颖的教育和咨询干预措施及预防策略。我与基础科学、人口科学和行为科学领域的同事建立了长期合作，以促进转化研究。我为癌症预防和控制领域的多层次科学家的培训做出了贡献。我代表癌症预防和控制领域的少数研究人员之一，他们将理论驱动的研究举措与临床环境的实际转化相结合。在我职业生涯的这个阶段，K05 奖将使我能够将这些努力扩展到不断增长且服务不足的女性群体，这些女性因良性乳腺疾病的诊断而患乳腺癌的风险增加。在分子医学的新时代，这一人群提供了一个理想的机会来研究癌症风险的早期分子特征，识别风险的遗传修饰因素，并根据病变的生物学特性制定预防方案。该奖项还将促进我在肿瘤内科奖学金中正规化新型临床遗传学培训轮换的努力，并将提供更多机会指导各级培训的学生。