Benign Breast Disease: A New Frontier for Prevention

良性乳腺疾病：预防的新领域

• 批准号: 6856701
• 负责人: MARY Beryl DALY
• 金额: $ 11.13万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-03-01 至 2010-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6856701
• 关键词: Benign; Breast; Disease; New; Frontier

DESCRIPTION (provided by applicant): For the past twenty years, I have been involved with the care of women with breast and ovarian cancer, and their families. During that time my research focus has gradually shifted from management of the disease to its prevention. This direction has been enhanced by the work of the Human Genome Project, which has made tremendous progress in advancing our understanding of the genetic basis of cancer, and by the increased awareness on the part of both the public and the health care community of the tremendous potential for disease prevention and control. Building on this framework, I have developed a nationally recognized research-based program, defined by familial cancer risk, in which to explore novel education and counseling interventions and prevention strategies. I have formed longstanding collaborations with colleagues in the basic sciences, population sciences and behavioral sciences to foster translational research. I have contributed to the training of scientists at many levels who are new to the field of cancer prevention and control. I represent one of a handful of investigators in the field of cancer prevention and control who combines theory-driven research initiatives with actual translation to the clinical setting. At this point in my career, the K05 award will allow me to extend these efforts to a growing and underserved population of women who are at increased risk for breast cancer because of a diagnosis of benign breast disease. In the new era of molecular medicine, this population provides an ideal opportunity to study early molecular signatures of cancer risk, to identify genetic modifiers of risk, and to tailor preventive options to the biology of the lesion. The award will also facilitate my efforts to formalize a novel clinical genetics training rotation within the medical oncology fellowship, and will afford more opportunities to mentor students at all levels of training.

描述（由申请人提供）：在过去的二十年中，我参与了乳腺癌和卵巢癌及其家人的照顾。在此期间，我的研究重点逐渐从疾病的管理转变为预防。人类基因组项目的工作增强了这一方向，这在促进了我们对癌症遗传基础的理解以及公众和卫生保健社区对疾病预防和控制的巨大潜力的认识方面取得了巨大进展。在此框架的基础上，我开发了一个由家庭癌症风险定义的全国认可的基于研究的计划，以探索新颖的教育和咨询干预措施和预防策略。我已经与基础科学，人口科学和行为科学的同事建立了长期的合作，以促进转化研究。我为在癌症预防和控制领域的许多层面上的科学家培训做出了贡献。我代表了癌症预防和控制领域的少数研究人员之一，他们将理论驱动的研究计划与实际转化为临床环境相结合。在我职业生涯的这一点上，K05奖将使我能够将这些努力扩展到日益增长的妇女人群，这些妇女因诊断出良性乳腺癌而患乳腺癌的风险增加。在分子医学的新时代，该人群为研究癌症风险的早期分子特征，确定风险的遗传改性剂，并为病变生物学量身定制预防选择。该奖项还将促进我在医学肿瘤学奖学金中进行新型临床遗传学培训轮换的正式努力，并将为在各个培训级别的各个培训中提供更多机会。