Personalized Medicine: Understanding and Utilization by Health Care Providers

个性化医疗：医疗保健提供者的理解和利用

• 批准号: 8141867
• 负责人: MARY Beryl DALY
• 金额: $ 6.19万
• 依托单位: FOX CHASE CANCER CENTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-30 至 2012-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8141867
• 关键词: Address; Adoption; Adverse event; Advocate; Behavioral; Behavioral Sciences; Caring; Characteristics; Classification; Communication; Communities; Complex; Computers; Confidentiality; Counseling; Development; Diagnosis; Disease; Education; Educational Curriculum; Enrollment; Ethical Issues; Ethics; Etiology; Evaluation; Family; Foundations; Fox Chase Cancer Center; Future; Genetic; Genetic Counseling; Genome; Genomics; Goals; Grant; Health; Health Personnel; Health Professional; Health behavior; Health protection; Healthcare; Healthcare Systems; Human Genetics; Individual; Information Technology; Institutes; Institution; Joint Ventures; Knowledge; Knowledge acquisition; Learning; Legal; Mainstreaming; Measures; Medical center; Medicine; National Human Genome Research Institute; Nature; Nurses; Outcome; Outcome Study; Patient Representative; Patients; Persons; Pharmaceutical Preparations; Physician Assistants; Physicians; Predisposition; Prevention; Preventive; Primary Health Care; Professional Education; Prospective Studies; Protocols documentation; Provider; Quality Control; Reaction; Recommendation; Research Design; Research Personnel; Resources; Risk; Role; Science; Scientific Advances and Accomplishments; Site; Technology; Testing; Therapeutic; Translations; United States; United States Dept. of Health and Human Services; University Hospitals; Update; Variant; Vision; clinical practice; clinically relevant; cohort; common treatment; cost; design; genetic risk assessment; genetic variant; genome-wide; patient safety; programs; public health relevance; randomized trial; skills; success; tool; uptake

PROJECT SUMMARY Personalized medicine is the use of an individual's genetic information to predict disease, avoid adverse drug reactions and tailor preventive and therapeutic strategies. It allows the classification of individuals into subpopulations that are distinguished by increased susceptibility to a particular disease or responsive to a specific treatment. Preventive or therapeutic strategies can then be concentrated on those most likely to benefit, sparing costs and adverse events for those who will not. Successful implementation of personalized medicine into the mainstream of health care will require a revolution in the knowledge and skills of primary care practitioners to include: 1) an understanding of the role of individual genetic variants in the etiology, prevention, diagnosis and treatment of common complex diseases; 2) the ability to effectively communicate personalized genetic information to patients and their families; and 3) the appropriate management of genetic variants. However the resources and opportunities for clinicians to update these skills and incorporate them into their practice are limited. We propose the development of an online program to address this educational and practice gap, for use within the Coriell Personalized Medicine Collaborative (CPMC). The CPMC is a joint venture with the Coriell Institute, Fox Chase Cancer Center (FCCC) and Cooper Medical Center. Its goal is to enroll 10,000 community residents into a prospective study to determine how to best implement the use of genome-wide genetic information in the management of common complex diseases. The CPMC is currently the only personalized medicine initiative being conducted in the United States within a rigorous scientific protocol that includes identified outcomes and quality control measures. A critical component of the success of this project will be the education of primary care providers about the genetics of complex disease, and the appropriate incorporation of individual genetic information into the care of their patients. This planning grant will build on the foundation of the recently launched CPMC and expand it to include the development of such educational tools and materials. We will capitalize on the expertise represented by these three institutions to achieve the following aims: 1. To create a Steering Committee composed of investigators at each site with expertise in genetics, genetic counseling, professional education, information technology, ethical issues related to genomics technologies and behavioral science; 2. To establish a Personalized Medicine Advisory Board, composed of providers, community representatives and patient advocates, to assist in all aspects of the developmental plan; 3. To develop, adapt and field test online educational tools for primary care providers (including physicians, physician assistants and nurses) to facilitate the appropriate incorporation of personalized medicine into their practices; 4. To design a comprehensive plan for the evaluation of the educational tools, including the acquisition of knowledge and skills, the dissemination of risk communication practices, and the impact of the communication of personalized genetic information on health behaviors.

项目摘要 个性化医学是使用个人的遗传信息来预测疾病，避免不良药物 反应和量身定制的预防和​​治疗策略。它允许个人分类 通过增加对特定疾病的敏感性或对某人的反应的亚群 具体处理。然后可以将预防或治疗策略集中在最有可能的人身上 对于那些不会的人来说，受益，支撑成本和不利事件。成功实施个性化 医学进入医疗保健主流将需要在初级保健的知识和技能上进行革命 从业者包括：1）了解个体遗传变异在病因，预防，预防， 常见复杂疾病的诊断和治疗； 2）有效交流个性化的能力 给患者及其家人的遗传信息； 3）遗传变异的适当管理。 但是，临床医生有资源和机会更新这些技能并将其纳入他们的技能 练习是有限的。我们建议开发一个在线计划，以解决此教育和 练习差距，用于在Coriell个性化医学合作（CPMC）中使用。 CPMC是关节 与科里尔研究所，福克斯·蔡斯癌症中心（FCCC）和库珀医疗中心合作。它的目标是 注册10,000名社区居民参加一项前瞻性研究，以确定如何最好地实施使用 普通复杂疾病管理中全基因组的遗传信息。 CPMC当前是 在严格的科学中，在美国进行的唯一个性化医学倡议 包括确定结果和质量控制措施的协议。成功的关键组成部分 该项目将是初级保健提供者关于复杂疾病的遗传学的教育， 将单个遗传信息适当地纳入患者的护理中。这项计划赠款将 建立在最近启动的CPMC的基础上，并将其扩展为包括此类开发 教育工具和材料。我们将利用这三个机构代表的专业知识 实现以下目的：1。建立一个由调查人员组成的指导委员会 遗传学，遗传咨询，专业教育，信息技术，与道德问题相关的专业知识 进行基因组技术和行为科学； 2。建立个性化医学顾问委员会， 由提供者，社区代表和患者倡导者组成，以协助各个方面 发展计划； 3。为初级保健提供者开发，适应和现场测试在线教育工具 （包括医师，医师助理和护士），以促进适当的合并 个性化医学来实践； 4。设计一个评估的全面计划 教育工具，包括获得知识和技能，风险交流的传播 实践以及个性化遗传信息对健康行为的交流的影响。