Units for HIV/AIDS Clinical Trials Networks

HIV/AIDS 临床试验网络单位

• 批准号: 7097816
• 负责人: Ram Yogev
• 金额: $ 231.08万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7097816
• 关键词: AIDS prevention; AIDS/HIV problem; Acquired Immunodeficiency Syndrome; Adolescent; Affect; Area; Catchment Area; Chicago; Child; Childhood; Clinical Research; Clinical Treatment; Clinical Trials Network; Communities; Enrollment; Epidemic; Goals; HIV; Immune system; Infection; International; Intervention; Morbidity - disease rate; Numbers; Pathogenesis; Patients; Pregnant Women; Prevention; Protocols documentation; Range; Research Personnel; Site; South Africa; Thailand; United States; Vaccines; Vertical Disease Transmission; Woman; base; clinical research site; design; experience; improved

DESCRIPTION (provided by applicant): The Chicago Clinical Treatment Unit (CTU) plans to participate in the clinical research proposed by the International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) network. Our goal is to participate in protocols that are hypothesis-based and pathogenesis-oriented trials designed to 1) advance the ability to interrupt mother-to-child transmission of HIV; 2) improve prevention and treatment interventions for children and adolescents in the United State and internationally; 3) evaluate treatments and prevention of co-infections and co-morbidities in HIV-infected children, adolescents and pregnant women; 4) evaluate vaccines for the prevention of HIV, or to boost the immune system of HIV-infected children and adolescents. The proposed four units of the Chicago CTU are located in different parts of the world. In Chicago, the wide-range catchment area of the Chicago Clinical Research Sites (CRS) and the linkages they have developed with many community-based agencies will allow us to reach effectively many of the children, adolescents and women known to be affected by the HIV epidemic in Chicago and the surrounding area. The addition of the two international CRSs will strengthen the ability of the CTU to pursue (and hopefully answer) scientific questions which are important to the international community where the majority of the pediatric and adolescent patients are located. US-based researchers with 20-plus years of HIV/AIDS expertise will share their experience and help the international sites to be more effective in their efforts to enroll and follow the large numbers of HIV-infected children, adolescents and women in South Africa and Thailand. ADMINISTRATIVE COMPONENT

描述（申请人提供）：芝加哥临床治疗中心（CTU）计划参与国际孕产妇儿科青少年艾滋病临床试验（IMPAACT）网络提出的临床研究。我们的目标是参与基于假设和以发病机制为导向的试验方案，旨在 1) 提高阻断 HIV 母婴传播的能力； 2）改善美国和国际儿童和青少年的预防和治疗干预措施； 3) 评估感染艾滋病毒的儿童、青少年和孕妇的合并感染和合并症的治疗和预防； 4) 评估预防艾滋病毒或增强感染艾滋病毒的儿童和青少年的免疫系统的疫苗。拟议的芝加哥 CTU 的四个单位位于世界不同地区。在芝加哥，芝加哥临床研究中心 (CRS) 的广泛服务范围及其与许多社区机构建立的联系将使我们能够有效地接触到许多已知受该疾病影响的儿童、青少年和妇女。芝加哥及周边地区的艾滋病毒流行。 两个国际 CRS 的加入将增强 CTU 追求（并有望回答）科学问题的能力，这些问题对于大多数儿科和青少年患者所在的国际社会非常重要。拥有 20 多年艾滋病毒/艾滋病专业知识的美国研究人员将分享他们的经验，并帮助国际站点更有效地登记和跟踪南非和南非的大量感染艾滋病毒的儿童、青少年和妇女。泰国。 行政部分