Units for HIV/AIDS Clinical Trials Networks

HIV/艾滋病临床试验网络单位

• 批准号: 7578309
• 负责人: Ram Yogev
• 金额: $ 125.17万
• 依托单位: LURIE CHILDREN'S HOSPITAL OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-02-01 至 2013-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7578309
• 关键词: AIDS prevention; AIDS/HIV problem; Adolescent; Affect; Area; Catchment Area; Chicago; Child; Childhood; Clinical Research; Clinical Treatment; Clinical Trials Design; Clinical Trials Network; Communities; Enrollment; Epidemic; Goals; HIV; Immune system; Infection; International; International Maternal Pediatric Adolescent AIDS Clinical Trials; Intervention; Morbidity - disease rate; Pathogenesis; Patients; Pregnant Women; Prevention; Protocols documentation; Research Personnel; Site; South Africa; Thailand; United States; Vaccines; Vertical Disease Transmission; Woman; base; clinical research site; experience; improved

DESCRIPTION (provided by applicant): The Chicago Clinical Treatment Unit (CTU) plans to participate in the clinical research proposed by the International Maternal Pediatric Adolescent AIDS Clinical Trial (IMPAACT) network. Our goal is to participate in protocols that are hypothesis-based and pathogenesis-oriented trials designed to 1) advance the ability to interrupt mother-to-child transmission of HIV; 2) improve prevention and treatment interventions for children and adolescents in the United State and internationally; 3) evaluate treatments and prevention of co-infections and co-morbidities in HIV-infected children, adolescents and pregnant women; 4) evaluate vaccines for the prevention of HIV, or to boost the immune system of HIV-infected children and adolescents. The proposed four units of the Chicago CTU are located in different parts of the world. In Chicago, the wide-range catchment area of the Chicago Clinical Research Sites (CRS) and the linkages they have developed with many community-based agencies will allow us to reach effectively many of the children, adolescents and women known to be affected by the HIV epidemic in Chicago and the surrounding area. The addition of the two international CRSs will strengthen the ability of the CTU to pursue (and hopefully answer) scientific questions which are important to the international community where the majority of the pediatric and adolescent patients are located. US-based researchers with 20-plus years of HIV/AIDS expertise will share their experience and help the international sites to be more effective in their efforts to enroll and follow the large numbers of HIV-infected children, adolescents and women in South Africa and Thailand. ADMINISTRATIVE COMPONENT

描述（由申请人提供）：芝加哥临床治疗部门（CTU）计划参加国际母亲小儿青少年艾滋病临床试验（Impaact）网络提出的临床研究。我们的目标是参与旨在基于假设的基于假设和以发病机理为导向的试验的方案，旨在提高中断艾滋病毒的母亲到儿童传播的能力； 2）改善美国和国际儿童和青少年的预防和治疗干预措施； 3）评估艾滋病毒感染儿童，青少年和孕妇的共同感染和共同感染的治疗和预防； 4）评估预防HIV的疫苗，或增强感染HIV感染的儿童和青少年的免疫系统。提议的芝加哥CTU的四个单元位于世界不同地区。在芝加哥，芝加哥临床研究地点（CRS）的广大集水区及其与许多基于社区的机构建立的联系将使我们能够有效地到达许多受HIV在芝加哥及周边地区受到HIV流行影响的儿童，青少年和妇女。 增加两个国际CRS将增强CTU追求（并希望回答）科学问题的能力，这对大多数儿科和青少年患者所在的国际社会很重要。拥有20多年艾滋病毒/艾滋病专业知识的美国研究人员将分享他们的经验，并帮助国际遗址更有效地努力入学并遵循南非和泰国的大量艾滋病毒感染的儿童，青少年和妇女。 管理组件