Exploring the Fetal Origins Hypothesis in Diverse Youth

探索不同青年的胎儿起源假说

• 批准号: 7251447
• 负责人: Dana Dabelea
• 金额: $ 52.09万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-14 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7251447
• 关键词: 11 year old; Adolescence; Adult; African American; Age; Autoimmunity; Biological; Birth; Birth Weight; Body Composition; Body Size; Body mass index; Cardiovascular Diseases; Cardiovascular system; Central obesity; Child; Childhood; Chronic; Chronic Disease; Colorado; Condition; Development; Diabetes Mellitus; Elderly; Enrollment; Ethnic group; Exposure to; Fatty acid glycerol esters; Fetal Growth; Fetus; Future; Genetic; Genetic Predisposition to Disease; Genotype; Glucose; Growth; Health Planning; Hispanics; Hormonal; Insulin; Insulin Resistance; Insulin-Dependent Diabetes Mellitus; Lead; Leptin; Leptin resistance; Life; Life Style; Low Birth Weight Infant; Measures; Mediating; Metabolic; Metabolism; Mothers; Muscle; Newborn Infant; Non-Insulin-Dependent Diabetes Mellitus; Not Hispanic or Latino; Obesity; Organ; Outcome; Overweight; Pathway interactions; Pattern; Perinatal Exposure; Phenotype; Pregnancy; Prevalence; Prevention; Prospective Studies; Relative (related person); Research; Research Design; Research Personnel; Risk; Risk Factors; Signal Transduction; Structure; Syndrome; Testing; Umbilical Cord Blood; United States; Visceral; Weight Gain; Youth; body system; cohort; diabetic; disorder risk; fetal; fetal programming; in utero; maternal diabetes; mortality; non-diabetic; novel; nutrition; obesity risk; programs; prospective; restraint

DESCRIPTION (provided by applicant): Fetal life is considered one of the critical (or sensitive) periods when an exposure may have lifelong effects. Increased adiposity in later life seems to occur at both ends of the birth weigh spectrum: generalized obesity with higher birth weight and increased visceral adiposity and its metabolic consequences at lower birth weights. Whether or not these phenotypes are detectable in exposed children and whether or not they have common biologic pathways is a focus of this proposal. The specific aims of this proposal are: Aim No. 1: To examine in parallel the long-term consequences of intrauterine exposure to excess nutrition (maternal diabetes) and under nutrition (growth restriction) on/childhood body size, fat patterning and markers of insulin resistance, among children of different ethnic groups. Aim No. 2. To explore hypothesis of intrauterine hormonal "programming" through which fetal exposures could increase the risk of obesity and insulin resistance in children. The proposed project is a prospective study proposing to enroll a total of 810 eight to eleven-year old offspring of diabetic pregnancies (exposed group-1), offspring of non-diabetic pregnancies with intrauterine growth restraint (exposed group-2), and control children (unexposed group), as well as their biological mothers, in three ethnic groups (non-Hispanic whites, Hispanics, and African-Americans). Comparison of exposed and unexposed groups will allow assessment and disentangling of the effects of exposure to diabetes mellitus in utero and intrauterine growth restraint on body size, fat patterning and insulin resistance markers and features later in childhood. The proposed research should also help understand whether these exposures have direct biological influences or are mediated through lifestyle choices. Such studies could ultimately lead to the development of strategies for early life prevention of future chronic disorders.

描述（由申请人提供）：胎儿寿命被认为是暴露可能具有终生影响的关键（或敏感）时期之一。后来生活中的肥胖增加似乎在出生权重谱的两端发生：肥胖症具有较高的出生体重和内脏肥胖的增加及其在较低出生体重时的代谢后果。这些表型是否在暴露的儿童中可以检测到以及他们是否具有共同的生物学途径是该提议的重点。该提案的具体目的是：目标1：在不同种族的儿童中，与/儿童体型的营养（生长限制）对/儿童身体大小，脂肪图案和胰岛素抵抗的标志物的长期后果以及在营养（生长限制）下的长期后果。目标2。探索宫内激素“编程”的假设，通过该假说，胎儿暴露可以增加儿童肥胖和胰岛素抵抗的风险。 The proposed project is a prospective study proposing to enroll a total of 810 eight to eleven-year old offspring of diabetic pregnancies (exposed group-1), offspring of non-diabetic pregnancies with intrauterine growth restraint (exposed group-2), and control children (unexposed group), as well as their biological mothers, in three ethnic groups (non-Hispanic whites, Hispanics, and非裔美国人）。对暴露和未暴露组的比较将允许评估和解散子宫内暴露于糖尿病的影响，以及宫内生长限制对体型，脂肪图案和胰岛素抵抗标记的影响，以及童年后期的特征。拟议的研究还应有助于了解这些暴露是直接的生物学影响还是通过生活方式选择进行介导。这样的研究最终可能导致发展未来慢性疾病的早期生活策略。