Oregon Alzheimer's Disease Center

俄勒冈阿尔茨海默病中心

• 批准号: 7120224
• 负责人: JEFFREY A KAYE
• 金额: $ 3.84万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-01-01 至 2010-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7120224
• 关键词: Alzheimer' s disease; biomedical facility; clinical research

DESCRIPTION (provided by applicant):The Oregon Alzheimer's Disease Center's (OADC) goal is to facilitate and advance research on Alzheimer's disease (AD) and related topics, concentrating our efforts to better define normal aging, the transitions to mild cognitive impairment (MCI) and early dementia. This will be achieved by maintaining five core facilities in association with expert core personnel to support current research strengths and to be responsive to new knowledge and discoveries in the field. The OADC is oordinated to be an efficient unit, working in concert with the research community to facilitate investigation in several major thematic areas such as studies of incipient dementia in the very elderly, the genetics of healthy brain aging, biomarkers of underlying disease, and alternative treatment regimens. The Clinical Core provides well characterized, longitudinally followed research subjects of several kinds: 1) early AD and related dementias; 2) non-cognitively impaired or MCI elderly at high risk for developing dementia, emphasizing the oldest old; and 3) subjects reflecting social and racial diversity (African American, Native American, and isolated rural populations). The Neuropathology Core is notably organized to maximize standardized diagnosis, availability of normative tissue, and research collaboration through the new Pacific Northwest Dementia and Aging (PANDA) Neuropathology Group, a cooperative effort of the OADC and University of Washington ADC Neuropathology Cores. The Genetics Core responds to the needs of this research with sophisticated characterization of research subjects and tissues by family history and genotype. The Genetics Core uniquely informs this research by creating a genomic resource for healthy brain aging. The Data Management and Statistics Core links all units with an efficient relational database creating a seamless pathway to ongoing and future collaborations with the National Alzheimer's Coordinating Center and other ADCs. The Data Core also provides important assistance and advice in design and statistical analysis to investigators. New information and knowledge of the field is disseminated through the Education and Information Transfer Core. This core uses a variety of educational forums ranging from small seminars to web-based information dissemination. The core's professional education programs emphasize empowering primary care providers to meet the challenge of insuring optimal brain aging for our senior population.

描述（由申请人提供）：俄勒冈州阿尔茨海默氏病中心（OADC）的目标是促进和提高对阿尔茨海默氏病（AD）及相关主题的研究，集中精力确定正常衰老，过渡到轻度认知障碍（MCI）和早期痴呆症。这将通过维护与专家核心人员合作的五个核心设施来支持当前的研究优势，并能够响应该领域的新知识和发现。 OADC被置于一个有效的单位，与研究界合作，促进了几个主要主题领域的研究，例如对老年人的初期痴呆，健康脑衰老的遗传学，潜在疾病的生物标志物的遗传学，替代治疗方案和替代治疗方案。临床核心提供了良好的特征，纵向遵循几种研究主题：1）早期AD和相关痴呆症； 2）非认知障碍或MCI老年人患痴呆症的高风险，强调了最古老的痴呆症； 3）反映社会和种族多样性的主题（非裔美国人，美国原住民和孤立的农村人口）。神经病理学的核心是通过新的西北太平洋痴呆症和衰老（PANDA）NEUROPAROGY Group，OADC和华盛顿大学ADC神经病理学核心的合作努力来最大化标准化诊断，规范组织的可用性以及研究合作。遗传学核心通过家族史和基因型对研究对象和组织的复杂表征响应了这项研究的需求。遗传学核心通过为健康的大脑衰老创造基因组资源来独特地为这项研究提供了信息。数据管理和统计核心将所有单元与有效的关系数据库联系起来，从而为与国家阿尔茨海默氏症协调中心和其他ADC的持续和未来合作创造了无缝的途径。数据核心还为研究人员提供了设计和统计分析的重要帮助和建议。该领域的新信息和知识通过教育和信息转移核心传播。该核心使用各种教育论坛，从小型研讨会到基于网络的信息传播。核心的专业教育计划强调，授权初级保健提供者能够应对为我们的老年人提供最佳脑老化的挑战。