Oregon Alzheimer's Disease Research Center

俄勒冈阿尔茨海默病研究中心

基本信息

批准号：
9922085
负责人：
JEFFREY A KAYE
金额：
$ 303万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-02-28
项目状态：
未结题

项目摘要

Project Summary: Overall The overarching goal of the Oregon Alzheimer’s Disease Research Center (OADRC) is twofold: (1) to focus on early detection of change in order to define mechanisms supporting healthy brain aging and the transition to MCI and early dementia, and (2) to facilitate developing effective therapies to prevent or limit these transitions. To achieve these objectives, eight cores and a Research Education Component are organized to catalyze and sustain innovative research and discovery in Alzheimer Disease and related dementias (ADRD) through an organizational infrastructure that supports a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. The OADC provides the necessary materials to support research through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. The OADRC focuses on specific areas of emphasis: 1) Preclinical dementia and activity of disease emphasizing the oldest old; 2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; 3) Neuropathology of brain aging and late life dementia; 4) Novel testing of novel treatments, and 5) Improving education and sharing knowledge about dementia. To attain these goals and objectives, the OADRC Specific Aims are to: 1. Catalyze and sustain innovative research and discovery in Alzheimer Disease and related disorders through an organizational infrastructure supporting a rich collaborative environment composed of leading edge technologies and methods, multi-disciplinary scientists, empowered research volunteers, and an inspired community of lay and professional stakeholders. 2. Focus the innovation and discovery infrastructure of the center toward specific areas of emphasis: (1) Preclinical dementia and activity of disease emphasizing the oldest old; (2) Markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; (3) Neuropathology of brain aging and late life dementia; (4) Novel testing of novel treatments; and (5) Improving education and knowledge about dementia. 3. Provide the necessary materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics. 4. Contribute to the national research commons relevant to Alzheimer’s disease and related disorders. 5. Provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders such as clinicians, patients and diverse family members to address the challenges of dementia.

项目概要：总体俄勒冈阿尔茨海默病研究中心 (OADRC) 的总体目标有两个：(1) 专注于及早发现变化，以确定支持健康大脑衰老和向大脑过渡的机制 MCI 和早期痴呆，(2) 促进开发有效的疗法来预防或限制这些转变。为了实现这些目标，组织了八个核心和一个研究教育部分来催化和通过以下方式维持阿尔茨海默病和相关痴呆症 (ADRD) 的创新研究和发现支持由领先技术组成的丰富协作环境的组织基础架构技术和方法、多学科科学家、授权的研究志愿者以及充满灵感的人 OADC 提供必要的材料来支持。通过明确的研究参与者、生物标本、脑组织、数据提供进行研究 OADRC 重点关注以下特定领域：1) 临床前痴呆和活动。疾病强调最年长的老人；2）通过外周研究捕获有意义的变化标记生物标志物、神经影像学和持续的家庭行为监测 3) 大脑衰老的神经病理学；和晚年痴呆症；4) 新疗法的新测试，以及 5) 改善教育和分享知识关于痴呆症。为了实现这些目标，OADRC 的具体目标是： 1. 通过以下方式促进和维持阿尔茨海默病及相关疾病的创新研究和发现支持由领先技术组成的丰富协作环境的组织基础设施技术和方法、多学科科学家、授权的研究志愿者以及充满灵感的人由非专业和专业利益相关者组成的社区。 2. 将中心的创新和发现基础设施集中于特定的重点领域：(1) 临床前痴呆和强调高龄老人的疾病活动性（2）有意义变化的标志物；通过外周生物标志物、神经影像学和持续家庭行为的研究捕获监测；（3）大脑衰老和晚年痴呆的神经病理学；（4）新疗法的新测试； (5) 改善痴呆症的教育和知识。 3. 通过特征鲜明的研究参与者提供必要的材料来支持科学，生物标本、脑组织、数据提供和分析。 4. 为与阿尔茨海默病及相关疾病相关的国家研究共享做出贡献。 5. 为新科学家的教育和培训以及教育和培训提供场所和机制。告知新移民、患者和不同家庭成员等主要利益相关者，以解决痴呆症的挑战。