Administrative Core

行政核心

• 批准号: 10203769
• 负责人: JEFFREY A KAYE
• 金额: $ 48.5万
• 依托单位: OREGON HEALTH & SCIENCE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-07-01 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10203769
• 关键词: African American; Aged, 80 and over; Aging; Alzheimer' s Disease; Alzheimer' s disease related dementia; Animal Welfare; Area; Behavior monitoring; Biological; Biological Assay; Biological Markers; Clinical; Clinical Research; Clinical Trials; Clinical Trials Unit; Clinical assessments; Collaborations; Communities; Community Participation; Data; Data Analyses; Dementia; Development; Disease; Education; Education and Outreach; Elderly; Ensure; Event; Fostering; Goals; Home; Image; Individual; Infrastructure; Institution; Knowledge; Lead; Left; Link; Monitor; Oregon; Participant; Peripheral; Policies; Productivity; Research; Research Design; Resources; Role; Science; Scientist; Side; Sister; Specimen; Standardization; Structure; Technology; Testing; Time; Tissues; Training and Education; United States National Institutes of Health; Universities; Work; aging brain; brain tissue; cohort; collaborative environment; cooperative study; data management; data sharing; education research; follow-up; high standard; human subject; improved; innovation; neuroimaging; neuropathology; novel; outreach; pre-clinical; preservation; programs; quality assurance; recruit; repository; statistics

Project Summary: Administrative Core The Administrative Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to AD and related disorders; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Administrative Core provides oversight, management and quality assurance for the activities of the Center. It acts as the lead unit in strengthening and improving existing links between scientific and appropriate lay community leaders and organizations both locally and nationally. It is responsible for fostering new and innovative research relevant to brain aging and the dementias wherever and whenever possible. The Administrative Core Specific Aims are to: 1. Coordinate and integrate the individual core units and resources of the OADRC and their interactions with each other, as well as with individual scientists, clinicians, educators and the community. 2. Oversee and monitor the directions and interactions of the Center, setting relevant goals and optimizing resource utilization, guided by input from the scientific and lay communities. 3. Perform ongoing, regular review of progress. Ensure each unit within the OADRC performs to standards of highest quality and productivity while operating in strict compliance with human subjects, animal welfare, scientific integrity, and financial policy requirements of the university and NIH. 4. Provide a structure and forum to foster and develop new and innovative research in brain aging and the dementias, including the OADRC Developmental Projects. 5. Facilitate collaborative research, scientific interactions, and data sharing transfer with other Alzheimer’s Disease Research Centers, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Cooperative Study Unit, the Alzheimer’s Clinical Trials Consortium, the National Centralized Repository for Alzheimer’s Disease and other relevant outside research groups.

项目摘要：行政核心 对行政核心的一致性支持OADRC 5个总体目的的总体特定目标：1） 通过一个通过一个 组织基础设施支持丰富的协作环境； 2）将资源集中于特定 重点：临床前痴呆症和疾病的活性强调了最古老的旧；标记 通过研究周围生物标志物，神经成像和连续的家庭捕获的有意义的变化 行为监测；大脑衰老和晚期痴呆的神经病理学；新颖治疗的新颖测试； 改善对痴呆症的教育和知识； 3）提供通过 特征良好的研究参与者，生物标本，脑组织，数据提供和分析； 4） 为与AD和相关疾病有关的国家研究共享贡献； 5）提供场地和 新科学家的教育和培训机制，以及教育和告知主要利益相关者。 OADRC的行政核心为活动提供监督，管理和质量保证 中心。它是加强和改善科学与现有联系的主要单位 适当的外行社区领导者和组织在本地和全国范围内。它负责培养 与大脑衰老和痴呆症有关的新的和创新的研究无论何时何地。这 管理核心特定的目的是： 1。协调和整合OADRC的各个核心单位和资源及其与他们的互动 彼此，以及个人科学家，临床医生，教育工作者和社区。 2。监督和监视中心的方向和互动，设定相关目标并优化 资源利用，以科学和外行社区的投入为指导。 3。进行持续的，定期审查进度。确保OADRC内的每个单元都达到标准 严格遵守人类受试者，动物福利，最高质量和生产力， 科学完整性以及大学和NIH的财务政策要求。 4.提供一个结构和论坛，以促进和开发大脑衰老的新的创新研究 痴呆症，包括OADRC发展项目。 5。促进与其他阿尔茨海默氏症的合作研究，科学互动和数据共享转移 疾病研究中心，国家阿尔茨海默氏症协调中心，阿尔茨海默氏病 合作研究部门，阿尔茨海默氏症的临床试验联盟，国家集中式存储库 阿尔茨海默氏病和其他相关的外部研究小组。