Clinical Core

临床核心

基本信息

批准号：
10641028
负责人：
Aimee Pierce
金额：
$ 99.66万
依托单位：
OREGON HEALTH & SCIENCE UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-07-01 至 2025-02-28
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10641028
关键词：
African American Aged, 80 and over Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Attention Behavior monitoring Biological Biological Markers Blood Clinic Clinical Clinical Research Clinical Trials Clinical assessments Collaborations Communities Computers Conduct Clinical Trials DNA Data Dementia Development Digital biomarker Disease Education Elderly Environment Fostering Goals Health Home Image Individual Infrastructure Investigator-Initiated Research Knowledge Liquid substance Magnetic Resonance Imaging Measures Methods Monitor Octogenarian Oregon Outcome Participant Peripheral Phase Population Positron-Emission Tomography Procedures Research Research Activity Research Design Research Personnel Research Subjects Resources Science Scientist Severity of illness Sister Sleep Specimen Standardization Telemedicine Testing Tissues Training Training and Education Work aging brain aging in place brain tissue career cohort collaborative environment computer generated cooperative study data acquisition data management data sharing dementia risk digital digital technology education research follow-up high risk improved innovation interest neuroimaging neuroimaging marker neuropathology novel outreach pharmacologic pre-clinical prevent programs recruit remote monitoring repository sensor statistics tool volunteer

African American Aged, 80 and over Aging Alzheimer&apos s Disease Alzheimer&apos s disease related dementia Area Attention Behavior monitoring Biological Biological Markers Blood Clinic Clinical Clinical Research Clinical Trials Clinical assessments Collaborations Communities Computers Conduct Clinical Trials DNA Data Dementia Development Digital biomarker Disease Education Elderly Environment Fostering Goals Health Home Image Individual Infrastructure Investigator-Initiated Research Knowledge Liquid substance Magnetic Resonance Imaging Measures Methods Monitor Octogenarian Oregon Outcome Participant Peripheral Phase Population Positron-Emission Tomography Procedures Research Research Activity Research Design Research Personnel Research Subjects Resources Science Scientist Severity of illness Sister Sleep Specimen Standardization Telemedicine Testing Tissues Training Training and Education Work aging brain aging in place brain tissue career cohort collaborative environment computer generated cooperative study data acquisition data management data sharing dementia risk digital digital technology education research follow-up high risk improved innovation interest neuroimaging neuroimaging marker neuropathology novel outreach pharmacologic pre-clinical prevent programs recruit remote monitoring repository sensor statistics tool volunteer

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项目摘要

Project Summary: Clinical Core The Clinical Core is aligned to support the overall specific aims of the OADRC's 5 overarching aims: 1) catalyze and sustain innovative research and discovery in AD and related dementias (ADRD) through an organizational infrastructure supporting a rich collaborative environment; 2) focus resources toward specific areas of emphasis: preclinical dementia and activity of disease emphasizing the oldest old; markers of meaningful change captured through studies of peripheral biomarkers, neuroimaging and continuous in-home behavioral monitoring; neuropathology of brain aging and late life dementia; novel testing of novel treatments; and improving education and knowledge about dementia; 3) provide materials to support the science through well-characterized research participants, biological specimens, brain tissue, data provision and analytics; 4) contribute to the national research commons relevant to ADRD; and 5) provide venues and mechanisms for education and training of new scientists, as well as educating and informing key stakeholders. The OADRC’s Clinical Core is organized facilitate the study of transitions from normative function to preclinical and early Alzheimer’s disease (AD), as well as providing the core infrastructure to facilitate developing needed treatments to prevent or moderate these transitions across the spectrum of disease severity. It is additionally the responsibility of this core to provide the infrastructure for a wide array of innovative and evolving research activities ranging from providing clinical study design expertise (in concert with the Data Management and Statistics Core) to support of treatment studies. In being continually responsive to its research community, the Clinical Core has developed focused special units to further enhance the provision of leading edge imaging, telemedicine and clinical trials conduct. Within this context the Clinic Core Specific Aims are to: 1. Identify, recruit, and longitudinally assess individuals necessary to provide a ready pool of well- characterized subjects for research emphasizing the presymptomatic to early AD spectrum. 2. Include the underserved African American older adult population in this research enterprise through an on- going coordinated Satellite Program, the African American Dementia Aging & Project (AADAPt). 3. Coordinate and assist in concert with its sister Cores, tissue, biospecimen (blood, CSF, DNA), neuroimaging, and digital biomarker data acquisition to facilitate research incorporating new and developing tools and methods in such rapidly progressing fields as neuroimaging, biomarkers, remote monitoring, telemedicine, and clinical trials. 4. Support investigator-initiated research pertaining to the dementias and foster research collaboration and data sharing both regionally and nationally.

项目摘要：临床核心对临床核心进行一致性，以支持OADRC 5个总体目的的总体特定目标：1）通过一个通过一个组织基础设施支持丰富的协作环境； 2）将资源集中于特定重点：临床前痴呆症和疾病的活性强调了最古老的旧；标记通过研究周围生物标志物，神经成像和连续的家庭捕获的有意义的变化行为监测；大脑衰老和晚期痴呆的神经病理学；新颖治疗的新颖测试；改善对痴呆症的教育和知识； 3）提供通过特征良好的研究参与者，生物标本，脑组织，数据提供和分析； 4）为与ADRD相关的国家研究共享贡献； 5）提供场地和机制新科学家的教育和培训，以及教育和告知主要利益相关者。 OADRC的临床核心组织有助于研究从正常功能到临床前的过渡以及早期的阿尔茨海默氏病（AD），并提供核心基础设施以促进所需的发展治疗以预防或适应跨疾病严重程度的这些过渡。另外是该核心有责任为各种创新和不断发展的研究提供基础设施活动范围从提供临床研究设计专业知识（与数据管理和统计核心）支持治疗研究。在不断响应其研究社区时，临床核心已开发出重点的特殊单位，以进一步增强前沿成像的提供，远程医疗和临床试验行为。在这种情况下，诊所核心特定目的是： 1。识别，招募和纵向评估所需的个人，以提供现成的良好库特征的研究受试者强调了早期AD频谱的持续性。 2。在这项研究企业中包括服务企业中服务不足的非裔美国人老年人进行协调的卫星计划，非裔美国痴呆症衰老和项目（AADAPT）。 3。协调并协助与其姊妹核心，组织，生物镜（血液，CSF，DNA），神经影像学和数字生物标志物数据获取，以促进结合新的和在诸如神经影像学，生物标志物，遥控器等快速发展领域中开发工具和方法监测，远程医疗和临床试验。 4。支持研究者发起的与痴呆症和促进研究合作有关的研究以及数据共享区域和全国。