New PET/CT System for Human and Non-human Primate Imaging

用于人类和非人类灵长类动物成像的新型 PET/CT 系统

• 批准号: 10632928
• 负责人: DOUGLAS J BALLON
• 金额: $ 200万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-04-01 至 2025-03-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632928
• 关键词: 12 year old; Address; Alzheimer' s Disease; Area; Basic Science; Biodistribution; Biomedical Research; Clinical Research; Computed Tomography Scanners; Core Facility; Dedications; Development; Disease; Funding; Genetic Diseases; Genetic Medicine; Goals; Grant; Human; Image; Inflammatory; Infrastructure; Institution; Investments; Malignant Neoplasms; Mental disorders; Mission; Multiple Sclerosis; Nature; Nerve Degeneration; Neurology; New York; Oncology; Organ; Parkinson Disease; Positron-Emission Tomography; Research; Research Personnel; Research Project Grants; Research Support; Stroke; System; Technical Expertise; Technology; Translational Research; Traumatic Brain Injury; United States National Institutes of Health; Universities; Vascular Diseases; Viral Vector; Vision; X-Ray Computed Tomography; biomedical imaging; college; detection sensitivity; frontier; human imaging; imaging facilities; imaging system; innovation; instrument; instrumentation; medical schools; meter; nonhuman primate; operation; precision medicine; programs; research and development; tool; 12 year old; Address; Alzheimer' s Disease; Area; Basic Science; Biodistribution; Biomedical Research; Clinical Research; Computed Tomography Scanners; Core Facility; Dedications; Development; Disease; Funding; Genetic Diseases; Genetic Medicine; Goals; Grant; Human; Image; Inflammatory; Infrastructure; Institution; Investments; Malignant Neoplasms; Mental disorders; Mission; Multiple Sclerosis; Nature; Nerve Degeneration; Neurology; New York; Oncology; Organ; Parkinson Disease; Positron-Emission Tomography; Research; Research Personnel; Research Project Grants; Research Support; Stroke; System; Technical Expertise; Technology; Translational Research; Traumatic Brain Injury; United States National Institutes of Health; Universities; Vascular Diseases; Viral Vector; Vision; X-Ray Computed Tomography; biomedical imaging; college; detection sensitivity; frontier; human imaging; imaging facilities; imaging system; innovation; instrument; instrumentation; medical schools; meter; nonhuman primate; operation; precision medicine; programs; research and development; tool

PROJECT SUMMARY Weill Cornell Medical College of Cornell University (WCM) requests High-End Instrumentation Grant Program support to purchase a new positron emission tomography/computed tomography (PET/CT) system for imaging humans and non-human primates. Our PET/CT operations are a major component of WCM strategic investment in crucial imaging infrastructure used to advance basic, translational and clinical research, and provides vital tools for our large and growing pool of investigators who utilize PET/CT in their projects. At this point, our existing PET/CT scanner is 12 years old and cannot handle the demand from our large and growing pool of NIH funded investigators. In addition, we now require features such as a long axial field-of-view that are not available on our current PET/CT configuration. WCM is a world leader in biomedical research, and our PET/CT operations have leveraged the technical expertise of our institution to provide support to 35 PET related research projects including 28 NIH supported grants. The proposed whole-body PET/CT scanner is the Vision Quadra system offered by Siemens Healthineers. This new instrument will provide us with state-of-the-art technology, including a 1 meter axial field of view and greatly increased detection sensitivity that will facilitate innovative research projects using PET/CT over the next two decades. Successful completion of this project will contribute significantly to our goal of understanding and treating a wide range of diseases, including neurodegeneration, cancers, psychiatric disorders, genetic disorders, inflammatory diseases, and vascular diseases. The PET/CT suite would be located at Weill Cornell Medical College’s Citigroup Biomedical Imaging Center (CBIC), which is a dedicated, comprehensive, imaging research and development facility located on the campus of the College. The CBIC operates as an imaging research Core facility that serves over 100 investigators from 12 institutions in the greater New York area. The proposed new scanner is critical to our mission of providing high-level, uninterrupted research support for investigators funded by the National Institutes of Health and other sponsors. The proposed scanner will largely replace our current Siemens Biograph mCT system, since its whole-body coverage will significantly advance our research into questions related to the multi-organ nature of many diseases. The new scanner would be used to address critical problems at the frontiers of neurology, including Alzheimer’s disease, Parkinson’s disease, multiple sclerosis, stroke, and traumatic brain injury, as well as genetic medicine, including studies of the biodistribution of viral vectors, and the development of precision medicine in oncology.

项目摘要 威尔·康奈尔大学康奈尔大学（WCM）请求高端仪器赠款 购买新的正电子发射断层扫描/计算机断层扫描（PET/CT）的计划支持 成像人类和非人类隐私的系统。我们的宠物/CT操作是 WCM用于推进基本，翻译和临床的关键成像基础设施的战略投资 研究，并为我们越来越多的研究人员提供了重要的工具，这些调查员利用PET/CT 项目。此时，我们现有的宠物/CT扫描仪已有12年的历史，无法应付 我们成长中的NIH资助的研究人员。此外，我们现在需要诸如 我们当前的PET/CT配置上没有长轴向视野。 WCM是一个世界 生物医学研究的领导者以及我们的PET/CT运营利用了我们的技术专长 机构为35个相关研究项目提供支持，其中包括28个NIH支持赠款。这 拟议的全身宠物/CT扫描仪是西门子卫生师提供的视觉Quadra系统。这 新仪器将为我们提供最先进的技术，包括1米的轴向视野和 大大提高了检测灵敏度，这将促进使用PET/CT的创新研究项目 接下来的二十年。成功完成该项目将极大地促进我们的理解目标 并治疗多种疾病，包括神经变性，癌症，精神疾病，遗传 疾病，炎症性疾病和血管疾病。 PET/CT套件将位于Weill Cornell 医学院的花旗集团生物医学成像中心（CBIC），这是一个专用，全面的成像 研究与开发设施位于学院校园。 CBIC作为成像运行 研究核心设施为大纽约地区12个机构的100多名调查人员提供服务。这 拟议的新扫描仪对于我们为提供高级，不间断的研究支持至关重要 由美国国立卫生研究院和其他赞助商资助的调查人员。拟议的扫描仪将很大程度上 替换我们当前的西门子生物分类MCT系统，因为它的全身覆盖范围将大大提高 我们研究与许多疾病的多器官性质有关的问题。新的扫描仪将是 用于解决神经病学领域的关键问题，包括阿尔茨海默氏病，帕金森氏病 疾病，多发性硬化症，中风和创伤性脑损伤以及遗传医学，包括研究 病毒载体的生物分布以及肿瘤学中精确医学的发展。