Small Animal 7.0 Tesla Magnetic Resonance Imaging and Spectroscopy System

小动物7.0特斯拉磁共振成像和光谱系统

• 批准号: 7125659
• 负责人: DOUGLAS J BALLON
• 金额: $ 200万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-06-01 至 2009-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7125659
• 关键词: 2 year old; Accounting; Amygdaloid structure; Anesthesia procedures; Angiography; Animal Disease Models; Animal Experiments; Animals; Area; Arts; Beds; Brain; Brain-Derived Neurotrophic Factor; Cities; Clinical; Clinical Research; Complement; Computer software; Core Facility; Data; Development; Diffusion; Diffusion Magnetic Resonance Imaging; Disease; Echo-Planar Imaging; Electrocardiogram; Endothelial Cells; Floor; Functional Imaging; Funding; Future; Grant; Head; Hospitals; Hour; Housing; Human; Human Resources; Huntington Disease; Image; Imaging Techniques; Investigation; Laboratories; Letters; Magnetic Resonance; Magnetic Resonance Imaging; Magnetic Resonance Spectroscopy; Magnetism; Massachusetts; Measures; Medical; Memorial Sloan-Kettering Cancer Center; Modeling; Monitor; Morphologic artifacts; Mus; Neoplasm Metastasis; Noise; Operating System; Operative Surgical Procedures; PET/CT scan; Parkinson Disease; Pattern; Pharmacology; Phase; Physiologic pulse; Positron-Emission Tomography; Predisposition; Preparation; Principal Investigator; Property; Protons; Pulse taking; Purpose; Radiology Specialty; Rattus; Relative (related person); Request for Proposals; Research; Research Personnel; Research Project Grants; Resolution; Retinoids; Scanning; Screening procedure; Series; Signal Transduction; Sinus; Site; Spectrum Analysis; Spielmeyer-Vogt Disease; Staging; Structure; System; Therapeutic; Three-Dimensional Image; Three-Dimensional Imaging; Time; Training; Transgenic Mice; Transgenic Mouse Facility; Transgenic Organisms; Translational Research; United States National Institutes of Health; Universities; Vendor; Week; Work; animal data; bioimaging; bone; brain tissue; college; design; design and construction; gene therapy; human subject; image processing; instrument; interest; leukemia/lymphoma; magnetic field; mouse model; neurotrophic factor; oncology; radiofrequency; research study; seal

DESCRIPTION (provided by applicant): In this proposal, funds are requested for a 7.0 Tesla 30 cm bore magnetic resonance imaging and spectroscopy system designed for imaging small animals. This system would be the first small animal magnetic resonance imaging system at Weill Medical College of Cornell University, and would satisfy a critical need in the development of animal models of disease. We have a particular interest in high- resolution anatomical and functional imaging of transgenic mice, and there currently is no magnetic resonance system suitable for that purpose that is accessible to Weill Medical College investigators. Specific projects to be undertaken by eleven independent NIH sponsored major users with a total of fourteen R01, one P01, and one U01 grants at the College will include 1) disease staging and therapeutic monitoring of leukemia and lymphoma, 2) functional and anatomical imaging of the developing brain, 3) magnetic resonance spectroscopy of Parkinson's and Huntington's diseases, 4) retinoid pharmacology and its applications in oncology, 5) gene therapy for Batten's disease, 6) functional analysis of brain derived neurotrophic factor, and investigation of 7) neurotrophins and 8) endothelial cell precursors in neoangiogenesis. Our transgenic mouse facility will provide animals for these projects. The proposed instrument would be sited at our two-year old Biomedical Imaging Research Center. This stand-alone facility currently houses both a 3.0 Tesla MRI system and whole-body PET/CT system for human subjects, as well as a small animal PET system. The human systems are dedicated to applications development and clinical research. The addition of a small animal MRI/MRS system would be the ideal complement to existing scanners and greatly facilitate translational research from small animals to humans. More importantly, it would enhance the assessment of transgenic mouse models of disease in our areas of interest. Space for the new instrument already exists in our Imaging Center, as future expansion was a planned component of the original build-out of the property in 2001. A well-established and financially supported administrative structure is in place as a Biomedical Imaging Core Facility to manage the system and serve the needs of investigators with projects involving small animal imaging as listed in this proposal.

描述（由申请人提供）：在此提案中，要求建立7.0特斯拉30厘米孔磁共振成像和专门用于成像小动物的光谱系统的资金。该系统将是康奈尔大学威尔医学院的第一个小型动物磁共振成像系统，并满足疾病动物模型的关键需求。我们对转基因小鼠的高分辨率解剖学和功能性成像特别感兴趣，目前没有适合该目的的磁共振系统，Weill医学院研究人员可以使用。 Specific projects to be undertaken by eleven independent NIH sponsored major users with a total of fourteen R01, one P01, and one U01 grants at the College will include 1) disease staging and therapeutic monitoring of leukemia and lymphoma, 2) functional and anatomical imaging of the developing brain, 3) magnetic resonance spectroscopy of Parkinson's and Huntington's diseases, 4) retinoid pharmacology and它在肿瘤学中的应用，5）基因治疗用于巴顿氏病的基因治疗，6）对脑衍生的神经营养因子的功能分析，并研究7）神经营养蛋白和8）新血管生成中的内皮细胞前体。我们的转基因老鼠设施将为这些项目提供动物。提出的仪器将位于我们两年历史的生物医学成像研究中心。该独立设施目前既容纳3.0特斯拉MRI系统和人类受试者的全身PET/CT系统，也设有一个小型动物宠物系统。人类系统致力于应用开发和临床研究。添加小动物MRI/MRS系统将是现有扫描仪的理想补充，并极大地促进了从小动物到人类的转化研究。更重要的是，它将增强对我们感兴趣领域的转基因小鼠模型的评估。新仪器的空间已经存在于我们的成像中心中，因为未来的扩展是2001年原始建筑物的计划的组成部分。建立了一个公认且具有财务支持的行政结构，作为一个生物医学成像核心设施，以管理系统，并在此提案中列出了涉及小型动物成像的项目的需求，并满足了调查人员的需求。