Major Cyclotron Upgrades and Refurbishment

主要回旋加速器升级和翻新

• 批准号: 10177451
• 负责人: DOUGLAS J BALLON
• 金额: $ 156.22万
• 依托单位: WEILL MEDICAL COLL OF CORNELL UNIV
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10177451
• 关键词: 20 year old; Area; Basic Science; Biomedical Research; Clinical Research; Computers; Core Facility; Cost Sharing; Costs and Benefits; Cyclotrons; Disease; Ensure; Failure; Funding; Genetic Diseases; Goals; Grant; Image; Inflammatory; Infrastructure; Institution; Investments; Malignant Neoplasms; Medicine; Memorial Sloan-Kettering Cancer Center; Mental disorders; Mission; Nerve Degeneration; New York; Positron-Emission Tomography; Radioisotopes; Research; Research Personnel; Research Project Grants; Research Support; Services; Technical Expertise; Technology; Translational Research; United States National Institutes of Health; Universities; Vascular Diseases; bioimaging; cost; end of life; innovation; instrumentation; ion source; medical schools; programs; radio frequency; radiotracer; research and development; tool

PROJECT SUMMARY Weill Medical College of Cornell University (Weill Cornell Medicine, WCM) and Memorial Sloan- Kettering Cancer Center (MSK) request High-End Instrumentation Grant Program support to purchase major upgrades and a refurbishment of our 20-year-old jointly owned and operated 19 MeV cyclotron. The cyclotron is a major component of WCM and MSK strategic investments in crucial imaging infrastructure used to advance basic, translational and clinical research, and is a vital tool for our large and growing pool of investigators who utilize positron emission tomography (PET) in their projects. At this point, all major components of the cyclotron are at or beyond their end of life and are facing end-of-service status due to lack of available parts. In some cases, the components are degraded to the point that catastrophic failure requiring significant downtime and cost is possible in the near term. In addition, in order to support our large and growing pool of NIH funded investigators, we require features that are not available in our current cyclotron configuration. WCM and MSK are world leaders in biomedical research, and our cyclotron partnership over the past 20 years has leveraged the technical expertise of both institutions to ensure efficient radioisotope while realizing the significant benefits of cost sharing. The proposed upgrades and refurbishment will provide us with new state-of-the-art cyclotron technology, including complete replacement of the ion source, radiofrequency, computer control, and target assembly subsystems, that will facilitate innovative research projects using PET over the next two decades. Successful completion of this project will contribute significantly to our goal of understanding and treating a wide range of diseases, including neurodegeneration, cancers, psychiatric disorders, genetic disorders, inflammatory diseases, and vascular diseases. The cyclotron is located at the Citigroup Biomedical Imaging Center (CBIC), which is a dedicated, comprehensive, imaging research and development facility located on the campus of the Medical College. The CBIC operates as an imaging research Core facility that serves over 100 investigators from 12 institutions in the greater New York area. The campus is immediately adjacent to the campus of Memorial Sloan-Kettering Cancer Center. MSK also operates a large imaging Core facility dedicated to oncologic applications. Both institutions have burgeoning imaging research programs with high demand for cyclotron-produced radiotracers used in positron emission tomography (PET). The proposed upgrades and refurbishment are critical to our mission of providing high-level, uninterrupted research support for investigators funded by the National Institutes of Health and other sponsors on both campuses.

项目摘要 康奈尔大学威尔医学院（Weill Cornell Medicine，WCM）和纪念Sloan- Kettering Cancer Center（MSK）要求购买高端仪器赠款计划支持 重大升级以及我们20岁共同拥有并经营19 Mev Cyclotron的翻新。 Cyclotron是WCM和MSK战略投资的主要组成部分 用于推进基本，转化和临床研究，是我们大型且不断增长的库的重要工具 在其项目中利用正电子排放断层扫描（PET）的调查人员。此时，所有专业 回旋子的组成部分在其生命的尽头或超出其终结状态，并且面临服务终止状态 缺少可用零件。在某些情况下，组件被降解至灾难性 在短期内可能需要大量停机时间和成本的故障。另外，为了 支持我们的大型NIH资助的调查员池，我们需要的功能不是 在我们当前的回旋子配置中可用。 WCM和MSK是生物医学研究的世界领导者， 而且，在过去20年中，我们的Cyclotron合作伙伴关系利用了这两个机构的技术专业知识 确保有效的放射性同位素，同时意识到成本分担的重大收益。拟议的升级 翻新将为我们提供新的最先进的回旋技术技术，包括完整 更换离子源，射频，计算机控制和目标组装子系统，将 在接下来的二十年中，促进使用PET的创新研究项目。成功完成 项目将对我们理解和治疗广泛疾病的目标做出重大贡献，包括 神经变性，癌症，精神病，遗传疾病，炎症性疾病和血管 疾病。回旋子位于花旗集团生物医学成像中心（CBIC），该中心是专用的， 全面的成像研究和开发设施位于医学院的校园内。这 CBIC是一家成像研究核心设施，为来自12个机构的100多名调查员提供服务 大纽约地区。该校园紧邻纪念斯隆 - 凯特林的校园 癌症中心。 MSK还经营着专门用于肿瘤应用的大型成像核心设施。两个都 机构的成像研究计划的迅速发展，对基克到产生的放射性示踪剂的需求很高 用于正电子发射断层扫描（PET）。拟议的升级和翻新对我们来说至关重要 为由国家资助的调查人员提供高级，不间断的研究支持的使命 卫生研究院和两个校园的其他赞助商。