MAGNETIC RESONANCE STUDIES OF BONE MARROW HEMATOPOIESIS

骨髓造血的磁共振研究

基本信息

批准号：
2445243
负责人：
DOUGLAS J BALLON
金额：
$ 10.57万
依托单位：
SLOAN-KETTERING INST CAN RESEARCH
依托单位国家：
美国
项目类别：
财政年份：
1994
资助国家：
美国
起止时间：
1994-07-01 至 2000-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/2445243
关键词：
biomedical equipment development blood volume bone marrow exam clinical biomedical equipment diagnosis design /evaluation diagnosis quality /standard hematology hematopoiesis human subject noninvasive diagnosis nuclear magnetic resonance spectroscopy phantom model rapid diagnosis spine

项目摘要

The goal of the proposed work is to develop a fast, quantitative, non- invasive method for estimating the fractional volume of bone marrow occupied by blood cells. In hematology, this parameter is known as the "percentage cellularity" and is used to gauge the total active bone marrow volume in a wide variety of clinical situations. Presently, the only way to measure the percentage cellularity is via a needle aspirate or biopsy. In addition to causing patient discomfort, biopsies and aspirates are limited to superficial areas of bone, such as the posterior iliac crest. There is presently no direct method for assessing the percentage cellularity at many important sites of blood cell production, such as the vertebrae. We have recently completed a pilot study using proton magnetic resonance spectroscopy which demonstrated the feasibility of non-invasively measuring the percentage cellularity in bone marrow. We now propose to develop an image based assay for the percentage cellularity which makes use of the relative concentrations of water and lipid in marrow as well as nuclear relaxation times and self-diffusion coefficients of water. The successful completion of this project would yield a fast method for assessing the percentage cellularity which eliminates the pain associated with the needle biopsy and provides information on blood cell production at previously inaccessible anatomical sites. With these new techniques it will be possible to 1) quantify expansion or contraction of the active marrow volume due to disease or after the administration of blood cell growth hormones, and possibly 2) identify areas of residual hematologic disease present after chemotherapy.

拟议工作的目的是开发快速，定量，非 - 估计骨髓的分数的侵入性方法被血细胞占据。在血液学中，此参数称为 “细胞百分比”，用于评估总活性骨髓在各种临床情况下的体积。目前，测量细胞百分比的唯一方法是通过A 针刺或活检。除了引起患者不适之外活检和抽吸物仅限于骨头的表面区域，例如后纹山峰。目前没有直接方法评估许多重要部位的细胞百分比产量，例如椎骨。我们最近使用质子磁共振完成了一项试点研究光谱法证明了非侵入性的可行性测量骨髓的细胞百分比。我们现在建议开发基于图像的测定百分比的细胞，这使得使用相对浓度的水和脂质在骨髓中以及核松弛时间和水的自扩散系数。该项目的成功完成将产生一种快速的方法评估细胞百分比，消除了疼痛进行针头活检并提供有关血细胞产生的信息在以前无法访问的解剖部位。使用这些新技术可能会1）量化活动的膨胀或收缩由于疾病或给药后导致的骨髓体积生长激素，甚至可能2）确定残留血液学区域化学疗法后存在的疾病。