COBRE: VAMC: PATHOLOGY CORE, COLON CANCER

COBRE：VAMC：病理学核心，结肠癌

• 批准号: 7171120
• 负责人: WILLIAM JM HRUSHESKY
• 金额: $ 7.31万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2006-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7171120
• 关键词: clinical research; colon neoplasms

DESCRIPTION (provided by applicant): The primary goal of this COBRE proposal is to increase the number of active, NIH-funded biomedical researchers in the State of SC. This will be accomplished through the combined efforts of a number of investigators at the USC who have merged their collective expertise in formation of a multidisciplinary research group studying the biology of colorectal cancer, its therapy, and its prevention. Colorectal cancer is a leading cause of cancer death in the US, with about 150,000 new cases and 56,000 deaths occurring annually. Current pharmacologic regimens provide only marginal benefit in managing the disease, owing to the drug resistance of colorectal tumors, as well as to the toxic side-effects evoked by these regimens. The biomedical scientists who have come together for this application have formed an interdisciplinary center, the Center for Colon Cancer Research (CCCR) that has focused its efforts around the problem of colorectal cancer. The research proposed in the current COBRE application has three aims. The first is to carry out research on specific molecular, biochemical, genetic, and lifestyle factors that impact upon colorectal cancer and its therapy. This will be done by supporting four projects led by promising junior faculty members. The second aim is to provide core facilities in support of these research projects, giving the lead investigators necessary state-of-the-art technical capabilities. The final aim is to manage a program through which the four young faculty, as well as ten new faculty to be recruited during the five-year period of the grant, are mentored by established investigators with substantive records in NIH funding. In all, the COBRE program proposed in this application will have two long-tern1 benefits. First, the number of NIH-competitive researchers in SC will increase. Second, the CCCR will be poised to apply for a program project grant in the area of colon cancer. Such grants are few in SC and in other IdeA states.

描述（由申请人提供）：该鞋底提案的主要目标是增加SC状态中活跃的，NIH资助的生物医学研究人员的数量。这将是通过南加州大学的许多调查人员的共同努力来实现的，他们合并了他们的集体专业知识，以组建一个多学科研究小组，研究了结直肠癌的生物学，其治疗及其预防。大肠癌是美国癌症死亡的主要原因，每年发生约15万例新病例和56,000例死亡。当前的药理学方案由于结直肠肿瘤的耐药性以及这些方案引起的有毒副作用，在管理该疾病方面仅提供边缘益处。为此应用而聚集在一起的生物医学科学家组成了一个跨学科中心，跨学科的中心，即结肠癌研究中心（CCCR），将其努力集中在大肠癌问题上。当前的毛绒应用程序中提出的研究具有三个目标。首先是对影响大肠癌及其治疗的特定分子，生化，遗传和生活方式因素进行研究。这将通过支持有前途的初级教师领导的四个项目来完成。第二个目的是提供支持这些研究项目的核心设施，从而为研究人员提供必要的最先进的技术能力。最终目的是管理一个计划，该计划通过该计划，以及在赠款的五年期间招募的十个新教师，由成熟的调查员指导NIH资助的实质性记录。总的来说，本申请中提出的毛绒计划将具有两个LongEnt1好处。首先，SC中的NIH竞争力研究人员的数量将增加。其次，CCCR将有望在结肠癌领域申请计划项目赠款。在SC和其他思想状态中，此类赠款很少。