TEMPORAL CONTROL OF DRUG DELIVERY

药物输送的时间控制

• 批准号: 3434090
• 负责人: WILLIAM JM HRUSHESKY
• 金额: $ 0.7万
• 依托单位: NEW YORK ACADEMY OF SCIENCES
• 依托单位国家: 美国
• 财政年份: 1990
• 资助国家: 美国
• 起止时间: 1990-02-01 至 1991-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/3434090
• 关键词: bioengineering /biomedical engineering; chronotherapy; drug administration rate /duration; drug delivery systems; drug vehicle; heart rhythm; hormone therapy; neoplasm /cancer chemotherapy; travel

The proposed 3-day NYAS-sponsored conference will bring together, for the first, time, chemical, electrical and biomedical engineers, pharmacologists, pharmaceutical scientists and chronobiologists to discuss the reasons for the development of drug delivery systems that can automatically administer temporally-optimized patterns of a single drug, multiple drugs or genetically-engineered protein molecules. The purpose of this meeting is ultimately to stimulate the development of safer and more effective therapies for a wide range of disorders by considering administration timing or patterning in time. The meeting will include 8 major lectures covering essential topics in depth and about 30 other talks between 10 and 20 minutes in length. A poster session (50 posters) for the first of 3 evenings will serve to get participants communicating freely early in the conference. Posters will be displayed throughout the meeting to serve as a focus for interaction and communication. The six scientific sessions will, respectively: relate the physiologic need for pulsatile delivery of hormones and the need for retrieval of medical information present within high frequency cardiovascular rhythms; the afternoon will detail the importance of circadian physiology and will focus upon the development of circadian-based drug delivery systems; on day 2 the necessity for circadian-based delivery of cancer treatments will be followed by an afternoon devoted to drug carriers, chemical-physical aspects of drug delivery and how these systems can be temporarily controlled; the morning of the third day will discuss the temporal coordination of mechanical and computerized electronic delivery systems; the meeting is to be concluded by a panel discussion which focuses upon clinical study designs required for elucidation of optimal temporal delivery patterns, successful drug-specific chronotherapies, device-based time-qualified treatments; finally, regulatory implications of the development of time-specified therapeutic preparations will be considered.

拟议的为期3天的NYAS赞助的会议将聚集在一起，为 首先，时间，化学，电气和生物医学工程师， 药理学家，药学科学家和年级生物学家讨论 开发药物输送系统的原因 自动管理单一药物的时间优化模式， 多种药物或遗传工程蛋白分子。 目的 这次会议最终将刺激更安全的发展以及更多 通过考虑 行政时机或及时构图。 会议将包括8 主要讲座涵盖了深度的基本主题，还有大约30个谈话 长度在10到20分钟之间。 海报会议（50海报） 3个晚上的第一个将有助于使参与者自由交流 在会议的早期。 海报将在整个会议上显示 作为互动和交流的重点。 六个科学 会议将分别：关联脉冲的生理需求 激素的传递和检索医疗信息的需求 存在于高频心血管节奏中；下午会 详细介绍昼夜节律生理学的重要性，并将专注于 开发基于昼夜节律的药物输送系统；在第2天 基于昼夜节律的癌症治疗的必要性将是 然后是一个专门用于药物载体的下午，化学物理 药物输送的各个方面以及如何临时这些系统 受控;第三天的早晨将讨论暂时的 机械和计算机电子输送系统的协调； 会议将由小组讨论结束，重点是 阐明最佳时间所需的临床研究设计 输送模式，成功的药物特定时间疗法，基于设备 时间合格的治疗；最后，对 将考虑开发时间指定的治疗制剂。