CHRONOTHERAPY OF ASTHMA WITH RESPECT TO INHALED STERIODS--COMPARATIVE EFFICACY

吸入类固醇治疗哮喘的时间疗法——疗效比较

• 批准号: 6245231
• 负责人: RICHARD MARTIN
• 金额: $ 2.65万
• 依托单位: UNIVERSITY OF COLORADO DENVER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-02-14 至 1997-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6245231
• 关键词: asthma; chronotherapy; clinical research; clinical trials; corticosteroids; drug administration rate /duration; drug screening /evaluation; human subject; human therapy evaluation; inhalation drug administration; respiratory disorder chemotherapy; respiratory function

To determine if there is a difference in pulmonary function in mild to moderately severe asthma when inhaled corticosteroids are administered as a single daily dose at 8am or 5:30pm versus four times a day dosing at 7am, noon, 7pm, and 10pm. To compare the magnitude of systemic and local effect of the three treatment schedules. To compare the effect on asthma symptoms of the three treatment schedules.

确定轻度至轻症患者的肺功能是否存在差异 吸入皮质类固醇时出现中度严重哮喘 每天上午 8 点或下午 5:30 服用单次剂量，而不是每天服用四次 上午 7 点、中午、晚上 7 点和晚上 10 点。 比较系统性和 三种治疗方案的局部效果。 为了比较效果 哮喘症状的三种治疗方案。