NEUROPEPTIDES IN LUNG DEVELOPMENT AND INJURY

神经肽在肺发育和损伤中的作用

• 批准号: 7165313
• 负责人: Mary E. Sunday
• 金额: $ 2.37万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-05-01 至 2006-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7165313
• 关键词: Primates; animal colony

Description (provided by applicant):The objective of this proposal is to support the continuing development of the Southwest National Primate Research Center (SNPRC). The SNPRC is located on the campus of the Southwest Foundation for Biomedical Research, its host institution. The SNPRC maintains over 6,000 nonhuman primates including baboons, rhesus macaques, cynomolgus macaques, chimpanzees, marmosets, tamarins, vervet monkeys, spider monkeys, and pigtail macaques. We maintain large breeding populations of baboons, rhesus macaques, cynomolgus macaques and marmosets. Our animal resources include the largest captive population of baboons anywhere in the world, the largest pedigreed population of any nonhuman primate species in the world, and a growing population of SPF Indian-origin rhesus macaques. During the current grant period, the SNPRC provided resources to 267 investigators from 27 states. The SNPRC is divided into five types of components: Administrative, Training and Outreach, Primate Colonies, Resource, and Resource-related Research components. These components are organized within three groups: Comparative Medicine, Virology and Immunology, and Genetics Group. Ongoing resource components include clinical and anatomic pathology; veterinary technical services; biomaterials collection and distribution; a blood, tissue and DNA repository; chimpanzee hepatitis surveillance; retrovirus diagnostics; flow cytometry; and molecular genetics services. Additional resources proposed for development include behavioral services; the nursery; a primate genomics database; array technologies; and endothelial cell technologies. Components also are proposed to develop and enhance nonhuman primate models for research on hepatitis, tuberculosis, Chagas' Disease, nematode infection, diabetes and cardiovascular disease.

描述（由申请人提供）：该提案的目的是支持西南国家灵长类动物研究中心（SNPRC）的持续发展。 SNPRC位于其东道机构的西南生物医学研究基金会的校园内。 SNPRC维持超过6,000多个非人类灵长类动物，包括狒狒，恒河猕猴，cynomolgus猕猴，黑猩猩，果果会，塔玛蛋白蛋白酶，坦玛林，蜘蛛猴，蜘蛛猴子和pigtail猕猴。我们维持大量的狒狒，恒河猕猴，cynomolgus猕猴和桃花心的繁殖种群。我们的动物资源包括世界上任何地方的狒狒俘虏人群，是世界上任何非人类灵长类动物中最大的谱系种群，以及越来越多的SPF印度 - 印度 - 原始恒河猕猴。在当前赠款期间，SNPRC为来自27个州的267名调查人员提供了资源。 SNPRC分为五种类型的组成部分：行政，培训和外展，灵长类动物殖民地，资源和与资源相关的研究组件。这些成分在三组内组织：比较医学，病毒学和免疫学以及遗传学组。正在进行的资源成分包括临床和解剖病理学；兽医技术服务；生物材料收集和分布；血液，组织和DNA储存库；黑猩猩肝炎监测；逆转录病毒诊断；流式细胞仪；和分子遗传学服务。提议开发的其他资源包括行为服务；托儿所；灵长类动物基因组学数据库；阵列技术；和内皮细胞 技术。还建议组件开发和增强非人类的灵长类动物模型，用于研究肝炎，结核病，查加斯病，线虫感染，糖尿病和心血管疾病。