REGULATION OF LUNG DEVELOPMENT AND DISEASE

肺部发育和疾病的调节

• 批准号: 7601211
• 负责人: Mary E. Sunday
• 金额: $ 0.5万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2007
• 资助国家: 美国
• 起止时间: 2007-07-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7601211
• 关键词: Age; Aging; Animals; Birth; Computer Retrieval of Information on Scientific Projects Database; Disease; Drosophila genus; Funding; Genes; Grant; Heterozygote; Homologous Gene; Hour; Individual; Institution; Knockout Mice; Life; Lung; Mus; Phenotype; Pulmonary Emphysema; Regulation; Research; Research Personnel; Resources; Respiratory Failure; Respiratory System; Source; Structure of parenchyma of lung; Time; United States National Institutes of Health; X-Ray Computed Tomography; lung development; mutant; research study

This subproject is one of many research subprojects utilizing the resources provided by a Center grant funded by NIH/NCRR. The subproject and investigator (PI) may have received primary funding from another NIH source, and thus could be represented in other CRISP entries. The institution listed is for the Center, which is not necessarily the institution for the investigator. We cloned npas3 as the mouse homolog of a Drosophila gene, trachealess, the null mutant of which completely lacks a respiratory system. 90% of our npas3-null mice die within a few hours after birth of respiratory failure, with severely emphysematous lungs. The npas3 heterozygotes (Het) live, but have varying degrees of emphysema and/or reactive airways disease. We don't know whether there are differences in the lung phenotype at different ages (i.e. worsening of emphysema with aging) or whether there is individual variability between different animals. Micro-CT scans will permit analysis of the lung tissue of individual animals at different time points. Comparison of one npas3-Het and one wild-type littermate is an important pilot experiment for the competing renewal of our grant.

该副本是利用众多研究子项目之一 由NIH/NCRR资助的中心赠款提供的资源。子弹和 调查员（PI）可能已经从其他NIH来源获得了主要资金， 因此可以在其他清晰的条目中代表。列出的机构是 对于中心，这不一定是调查员的机构。 We cloned npas3 as the mouse homolog of a Drosophila gene, trachealess, the null mutant of which completely lacks a respiratory system. 90% of our npas3-null mice die within a few hours after birth of respiratory failure, with severely emphysematous lungs. The npas3 heterozygotes (Het) live, but have varying degrees of emphysema and/or reactive airways disease.我们不知道不同年龄的肺表型是否存在差异（即肺气肿随衰老而恶化），还是不同动物之间的个体变异性。 Micro-CT scans will permit analysis of the lung tissue of individual animals at different time points. Comparison of one npas3-Het and one wild-type littermate is an important pilot experiment for the competing renewal of our grant.