Expansion and modification of animal housing and support spaces to increase production of the NIH U42 supported pigtailed macaque colony at Johns Hopkins University

扩大和改造动物饲养和支持空间，以增加约翰·霍普金斯大学 NIH U42 支持的猪尾猕猴群的产量

• 批准号: 10592753
• 负责人: Eric Kenneth Hutchinson
• 金额: $ 550.02万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-09-20 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10592753
• 关键词: AIDS/HIV problem; Animal Housing; Animal Model; Animals; Area; Behavioral; Biomedical Research; Breeding; COVID-19; Communities; Farm; Fiber Optics; Funding; Health behavior; Human Resources; Institution; Internet; Macaca nemestrina; Modeling; Modification; Network Infrastructure; Operating Rooms; Primates; Production; Productivity; Radiology Specialty; Records; Research; Research Personnel; Resources; Sales; Security; Speed; United States National Institutes of Health; Universities; design; improved; innovation; nonhuman primate; novel

Project Summary In the face of well-documented ongoing shortages of nonhuman primates for biomedical research and evidence that they may be a unique model for COVID-19, it is no surprise that the demand for pigtail macaques remains strong and continues to climb. Since the onset of NIH- support in 2006, the JHU pigtail macaque colony has provided 313 animals for biomedical research, the vast majority of which was HIV/AIDS related. With 172 of those animals (55%) going to NIH funded investigators at institutions outside of JHU, we have established our colony as an important national resource of this valuable animal model. To meet the growing need for pigtail macaques in biomedical research, we have developed a plan to significantly increase the number of animals that we can house at the JHU Research Farm and further refine our behavioral management of this breeding colony to improve productivity. First, we propose to construct an addition to the existing Building 12, significantly expanding animal housing and support spaces. This new construction will include animal housing space and innovative caging for 120 additional animals across 6 harems. This addition will also house dedicated support spaces, including an operating room, radiology room, flex holding space for convalescing or pre- sale animals, and a cage washing area, along with personnel spaces such as a staff locker room with connected showers, bathroom, laundry, and PPE donning/doffing area. Second, we propose to install underground fiber optic cable and other network infrastructure to connect the JHU Research Farm facilities to high-speed internet. This project will allow us to fully leverage the soon-to-be-installed JHU-funded upgrades to 1) security and 2) electronic animal health and behavior records. If this proposal is successful, we will better serve the NIH-funded research community that relies on primate models in two key ways: 1) we will increase the number of animals available to researchers and 2) we will evaluate the novel husbandry and behavioral management features designed into the new building and share our findings with NIH-funded nonhuman primate researchers and other national breeding centers.

项目摘要 面对有据可查的非人类灵长类动物的持续记录 研究和证据表明它们可能是19009的独特模型，也就不足为奇了 对辫子猕猴的需求仍然很大，并继续攀升。自NIH的发作以来 2006年的支持，Jhu辫子猕猴菌落为生物医学提供了313只动物 研究，其中绝大多数与艾滋病毒/艾滋病有关。其中172只动物（55％） 去JHU以外机构的NIH资助的调查员，我们建立了我们的殖民地 作为这种宝贵动物模型的重要国家资源。满足日益增长的需求 生物医学研究中的辫子猕猴，我们制定了一项计划，以显着增加 我们可以在JHU研究农场容纳的动物数量，并进一步完善我们的动物 该繁殖群落的行为管理以提高生产率。首先，我们建议 构建现有建筑物12的补充，大大扩大了动物住房和 支持空间。这种新建筑将包括动物住房空间和创新的笼子 在6个后宫的120种动物中。此增加还将容纳专门的支持 空间，包括手术室，放射室，弹性握持空间用于康复或预先 销售动物和笼子洗衣区，以及人员储物柜等人员空间 淋浴，浴室，洗衣和PPE戴/doffing区域的房间。第二，我们 建议安装地下光纤电缆和其他网络基础架构以连接 JHU研究农场设施高速互联网。这个项目将使我们能够充分利用 即将安装的JHU资助的升级到1）安全性和2）电子动物健康和 行为记录。如果该提议成功，我们将更好地为NIH资助的研究服务 以两种关键方式依靠灵长类动物模型的社区：1）我们将增加 研究人员可用的动物2）我们将评估新颖的饲养和行为 新建筑中设计的管理功能，并与NIH资助 非人类灵长类动物研究人员和其他国家繁殖中心。