Resources and Workforce Development for the Tulane Regional Biocontainment Laboratory

杜兰地区生物防护实验室的资源和劳动力发展

• 批准号: 10794123
• 负责人: JAY RAPPAPORT
• 金额: $ 287.82万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-22 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10794123
• 关键词: COVID-19; COVID-19 pandemic; Communicable Diseases; Dedications; Development; Emerging Communicable Diseases; Ensure; Equipment; Funding; Goals; Grant; Health; Human; Infrastructure; Laboratories; Maintenance; Methodology; National Institute of Allergy and Infectious Disease; Operative Surgical Procedures; Primates; Procedures; Process; Public Health; Quality Control; Research; Research Infrastructure; Resource Development; Safety; Structure; Toxin; Training; United States National Institutes of Health; Universities; Work; Workforce Development; animal colony; base; biodefense; biosafety level 3 facility; emerging pathogen; fortification; germ free condition; improved; in vivo; medical countermeasure; nonhuman primate; operation; pandemic preparedness; pandemic response; pathogen; programs; response; safety practice; success

The Tulane National Primate Research Center (TNPRC) is one of seven National Primate Research Centers (NPRCs) dedicated to conducting nonhuman primate (NHP) research with the goal of improving human health. With a primary focus on infectious disease and biodefense research, the TNPRC is only NPRC with a Regional Biocontainment Laboratory (RBL) at Biosafety Level 3 (BSL-3) for the study of high-consequence pathogens, including select agents and toxins. The Tulane University RBL, which came online in June 2010, has been critical for advancing research at the TNPRC and across the region on biodefense agents and emerging infectious diseases, with a primary focus on in vivo studies using NHPs. Since its inception, significant infrastructure projects have been completed to capitalize on the presence of the RBL and grow and diversify research at the TNPRC. In recent years, and particularly with the onset of the COVID-19 pandemic, the TNPRC RBL has expanded its capabilities and capacity to accommodate BSL-3-level emerging pathogen and biodefense research. The overarching goal of the proposed project is to strategically enhance and fortify BSL-3 research capabilities within the TNPRC RBL to ensure the long-term success of this program in support of infectious disease and biodefense research and countermeasure development. This will be accomplished through the following Specific Aims: (1) Ensure agility of the TNPRC RBL response to emerging public health concerns and threats by leveraging the robust research infrastructure and unique research strengths of the TNPRC and implementing exceptional preventative maintenance processes that allow for best practices, quality control, and extensive safety oversight for work with high- consequence pathogens. (2) Provide formal structure for sharing of best practices for safety, research procedures and facilities management with partners and other RBLs. (3) Coordinate practices and procedures across the Biodefense Facilities Network to leverage the strengths of all 12 RBLs; ensure efficient and effective cross-training and sharing of methodologies, SOPs, and best practices; and coordinate and advance infectious disease and biodefense research and countermeasure development nation-wide.

杜兰国家灵长类动物研究中心 (TNPRC) 是七个国家灵长类动物研究中心之一 研究中心（NPRC）致力于与非人类灵长类动物（NHP）进行研究 改善人类健康的目标。主要关注传染病和生物防御 研究，TNPRC 是唯一在以下地点设有区域生物防护实验室 (RBL) 的 NPRC： 生物安全级别 3 (BSL-3)，用于研究高后果病原体，包括选定的药物 和毒素。杜兰大学 RBL 于 2010 年 6 月上线，对于 推进 TNPRC 和整个地区的生物防御剂和新兴技术研究 传染病，主要关注使用 NHP 进行体内研究。自成立以来， 重要的基础设施项目已经完成，以充分利用 RBL 的存在 发展 TNPRC 的研究并使研究多样化。近年来，特别是随着 在 COVID-19 大流行期间，TNPRC RBL 扩大了其能力和能力，以 适应 BSL-3 级新兴病原体和生物防御研究。总体目标 拟议项目的目的是战略性地增强和加强 BSL-3 的研究能力 TNPRC RBL 确保该项目在支持传染病方面取得长期成功 以及生物防御研究和对策开发。这将通过以下方式完成 以下具体目标： (1) 确保 TNPRC RBL 响应新兴公众的敏捷性 利用强大的研究基础设施和独特的研究来解决健康问题和威胁 发挥 TNPRC 的优势并实施特殊的预防性维护流程， 允许对高强度工作进行最佳实践、质量控制和广泛的安全监督 后果病原体。 (2) 提供共享最佳安全实践的正式结构， 与合作伙伴和其他 RBL 的研究程序和设施管理。 (3) 坐标 整个生物防御设施网络的实践和程序，以利用 所有 12 个 RBL；确保高效、有效的交叉培训和共享方法、标准操作程序、 和最佳实践；协调和推进传染病和生物防御研究 全国范围内制定对策。