TNPRC Regional Biocontainment Laboratory Upgrade for Capacity Building

TNPRC 区域生物防护实验室升级以进行能力建设

• 批准号: 10632933
• 负责人: JAY RAPPAPORT
• 金额: $ 344.3万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-23 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10632933
• 关键词: 2019-nCoV; Appointment; COVID-19; COVID-19 pandemic; Caring; Centers for Disease Control and Prevention (U.S.); Communicable Diseases; Communities; Containment; Decontamination; Detection; Development; Emerging Communicable Diseases; Ensure; Epidemic; Equipment; Faculty; Flow Cytometry; Funding; Future; Goals; Growth; Health; Human; IACUC; Immunology; Infrastructure; Joints; Laboratories; Liquid substance; Mission; Modernization; Outcome; Power Sources; Primates; Public Health; Pulmonology; Regulation; Research; Research Activity; Research Personnel; Resources; Safety; Series; Services; Site; System; Talents; Therapeutic; Tissue Sample; Toxin; Tropical Medicine; United States National Institutes of Health; Update; Vaccines; Validation; Work; animal model development; animal resource; biodefense; diagnostic assay; emerging pathogen; exhaust; improved; medical schools; multidisciplinary; nonhuman primate; novel diagnostics; operation; pathogen; population health; product development; programs; quality assurance; repaired; research clinical testing; response; restoration; risk minimization; virology; wasting

The Tulane National Primate Research Center (TNPRC) is one of seven NPRCs that serve as local, regional, and national resources to conduct nonhuman primate (NHP) research with the goal of improving human health. The TNPRC maintains a focus on infectious diseases and is the only NPRC with a Regional Biocontainment Laboratory (RBL) at biosafety level 3 (BSL-3) for the study of high consequence pathogens, including select agents and toxins, and biodefense research. In recent years, and particularly with the onset of the COVID-19 pandemic, the TNPRC RBL has seen massive growth in emerging pathogen and biodefense work. The facility is in critical need of additional upgrades, modernization projects, and laboratory enhancements, both to support the rapidly growing demand for BSL-3 research and to ensure a robust and efficient containment system that is vital for protecting workers, the Center, and the surrounding community. The purpose of the proposed project is to strategically enhance research capabilities by introducing new equipment space within the TNPRC RBL to accommodate our growing BSL-3 research portfolio. To this end, we propose the following specific aims: Aim 1. Implement a series of improvements to the TNPRC RBL infrastructure, including replacement of damaged phoenix valves, restoration of DeCon Tank capabilities, upgrade of uninterruptible power supply (UPS) systems, and update of the boiler burner which can no longer be repaired due to the discontinued manufacturing of replacement parts. Aim 2. Upgrade equipment to expand clinical evaluation capabilities in the BSL-3. Aim 3. Incorporate functional equipment pieces to support BSL-3 research activities, enabling and expanding the capacity of the RBL to conduct numerous research capabilities where regulations are extensive to be able to take them into non-select agent space. The ability to respond to potential epidemics rapidly and efficiently by developing and applying novel diagnostic assays, therapeutics, and vaccines is critical to minimize risk and negative population health outcomes. The TNPRC is uniquely capable of quickly responding to emerging threats, from detection through product development, due to our status as the only NPRC with an on-site BSL-3 Regional Biocontainment Laboratory, unique Quality Assurance Program, and extensive support of on-site core services. By mid-February 2020, we had already established a COVID-19 research program, with Centers for Disease Control & Prevention (CDC)-permitted acquisition of SARS-CoV-2 stock and IACUC approval of our animal model development studies. The TNPRC has a highly talented group of investigators with nationally recognized expertise in biocontainment, virology, immunology, pulmonology, vaccines, and veterinary care. Our faculty, with joint appointments in Departments across the Tulane Schools of Medicine and Public Health & Tropical Medicine, are involved in the development of multiple collaborative planning efforts locally, regionally, and nationally, including a Tulane-funded multidisciplinary Center of Excellence for Emerging/Re- emerging Infectious Disease (CEERID) and an application for federal funding of a Center of Excellence for Emerging Pathogens. Evidence of the impact of our collaborative research efforts is demonstrated by the allocation of close to 75% of animal resources to affiliate investigators and distribution of nearly 90,000 tissue samples to 461 NIH-funded collaborators in a recent 5-year period. This broad network of investigators will rely on the proposed project to enhance the capability and quality of our work and mission in support of studies directed toward the safe and rapid response to high consequence pathogens.

杜兰国家灵长类动物研究中心（TNPRC）是七个NPRC之一，作为本地， 进行非人类灵长类动物（NHP）研究的地区和国家资源，目的是 改善人类健康。 TNPRC保留着关注传染病，是唯一的NPRC 在生物安全3级（BSL-3）的区域生物疗养实验室（RBL）进行高 后果病原体，包括精选药物和毒素，以及生物粘素研究。最近 多年，尤其是随着Covid-19的大流行的发作，TNPRC RBL已经看到了大量 新兴的病原体和生物化工作的增长。该设施迫切需要额外 升级，现代化项目和实验室增强功能，都支持快速增长 对BSL-3研究的需求，并确保一个适用于强大而有效的遏制系统 保护工人，中心和周边社区。拟议项目的目的 是通过在策略性地提高研究能力来通过引入新的设备空间 TNPRC RBL可容纳我们不断增长的BSL-3研究组合。为此，我们提出了 遵循特定目的： 目标1。对TNPRC RBL基础架构进行一系列改进，包括更换 受损的凤凰阀，恢复DECON储罐功能，升级不间断的功率 供应（UPS）系统和锅炉燃烧器的更新，由于 停产的替换零件制造。 AIM 2。升级设备以扩大BSL-3中的临床评估功能。 目标3。合并功能设备来支持BSL-3研究活动，启用和 扩大RBL的能力，以执行法规的众多研究能力 大量能够将它们带入非选择代理空间。 通过开发和应用新颖的方法来快速有效地响应潜在流行病的能力 诊断测定，治疗剂和疫苗对于最大程度地降低风险和负人数至关重要 健康结果。 TNPRC具有独特的能力，能够快速应对新兴威胁 由于我们作为现场BSL-3的唯一NPRC的地位，通过产品开发进行检测 区域生物疗养实验室，独特的质量保证计划以及广泛的支持 现场核心服务。到2020年2月中旬，我们已经建立了一项COVID-19 计划，具有疾病控制与预防中心（CDC）的SARS-COV-2的收购 我们的动物模型开发研究的库存和IACUC批准。 TNPRC有一个高度 才华横溢的研究人员具有全国认可的生物内在，病毒学专业知识， 免疫学，肺病学，疫苗和兽医护理。我们的教师，共同任命 杜兰大学医学与公共卫生与热带医学的部门是 参与本地，地区和地区的多项协作计划工作的发展 在全国 新兴的传染病（CEERID）和联邦资助的申请 新兴病原体卓越。我们协作研究工作影响的证据是 通过将近75％的动物资源分配给会员调查员和 在最近的5年 时期。这个广泛的调查人员网络将依靠拟议的项目来 增强功能 我们的工作质量和使命，以支持针对安全，快速反应的研究 高后果病原体。