Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory

密苏里大学区域生物防护实验室 NIH/NIAID 高优先级病原体研究的资源和劳动力发展

• 批准号: 10793827
• 负责人: Wendy L Picking
• 金额: $ 259.55万
• 依托单位: UNIVERSITY OF MISSOURI-COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2023
• 资助国家: 美国
• 起止时间: 2023-08-18 至 2028-07-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10793827
• 关键词: 2019-nCoV; Acceleration; Address; Adoption; Animal Housing; Animal Model; Appointment; Arboviruses; Area; Award; COVID-19; COVID-19 pandemic; Communicable Diseases; Communities; Core Facility; Decontamination; Dedications; Development; Disease Outbreaks; Disinfectants; Emerging Communicable Diseases; Equipment; Evaluation; Event; Evolution; Faculty; Funding; Future; Goals; Grant; Growth; Human; Human Resources; Image; Immunology; Infection; Infectious Diseases Research; Influenza; Infrastructure; Institution; Investments; Knowledge; Laboratories; Leadership; Maintenance; Microbiology; Midwestern United States; Mission; Missouri; Modernization; Names; National Institute of Allergy and Infectious Disease; National Security; Output; Phase; Preparation; Prevention approach; Productivity; Public Health; Regulation; Research; Research Personnel; Research Support; Resource Development; Resources; Role; Safety; Scientist; Secure; Security; Senior Scientist; Services; System; Technology; Training; United States National Institutes of Health; Universities; Virus; Work; Workforce Development; animal model development; biodefense; combat; coronavirus disease; experience; improved; instrumentation; laboratory experiment; medical countermeasure; member; microbial; new outbreak; new technology; next generation; novel; novel strategies; operation; pandemic disease; pandemic potential; pandemic preparedness; pathogen; prevent; priority pathogen; programs; public health relevance; recruit; research and development; response; synergism; transmission process; vaccine platform; vector-borne

Overall Project Summary Resources and Workforce Development for Research on NIH/NIAID High Priority Pathogens at the University of Missouri Regional Biocontainment Laboratory The University of Missouri Regional Biocontainment Laboratory (RBL) was commissioned in 2009 as an $18M, 12,377 NSF BSL-3/ABSL-3 facility. During its thirteen years of operation, the RBL, since named the MU Laboratory for Infectious Disease Research (LIDR) has been a centerpiece of the broader infectious disease research community at the University of Missouri, receiving strong institutional commitment in the recruitment and sustainment of world-class faculty for management of the RBL/LIDR and for conducting research on high priority pathogens. The LIDR operates shared research resources, including state-of-the-art equipment and professional services in microbiology, aerobiology, immunology, and animal model core facilities that serve the needs of researchers on campus and in the broader regional and national communities. The faculty and professional staff of the LIDR are part of the NIH/NIAID RBL-NBL network, with collaborative interactions that facilitate sharing of best practices and knowledge, providing synergy in achieving our collective biodefense and emerging infectious disease research agenda. During the COVID pandemic, the MU LIDR, along with its RBL and NBL partners, led the response to the pandemic and are committed to strengthening pandemic preparedness of the nation, by providing BSL-3/ABSL-3 training, professional staff, and research services that allow for rapid responses in all areas, including development of animal models and the evaluation of numerous treatments, disinfectants, and vaccine platforms to combat the pandemic. The long-term goal of the present application is to sustain a leading effort for development of novel medical countermeasures for combating the ever present and changing threats of emerging and re-emerging infectious diseases, while training an outstanding cadre of next generation scientists and professionals in biocontainment. The goals of the proposed cores in Facility Management, Maintenance and Operations, BSL3 Practices, and Biocontainment Research Support Services are to educate and train the next generation of scientists and biocontainment professionals in biodefense and emerging infectious diseases, and to facilitate and enhance the development of novel approaches for prevention and treatment of infections caused by high consequence pathogens whose natural or deliberate transmission pose a threat to public health and national security. Towards these goals, the proposed Cores will work within the broader infectious disease community at MU and the NIH/NIAID RBL-NBL network for enhancement of research productivity and discovery, and continued sharing of information and best practices in order to meet the changing priorities and needs of NIH/NIAID for biodefense and emerging infectious diseases.

项目总体概要 大学 NIH/NIAID 高优先级病原体研究的资源和劳动力发展 密苏里州地区生物防护实验室 密苏里大学区域生物防护实验室 (RBL) 于 2009 年投入使用，耗资 1800 万美元， 12,377 NSF BSL-3/ABSL-3 设施。在其十三年的运营过程中，RBL 自命名为 MU 传染病研究实验室 (LIDR) 一直是更广泛的传染病研究的核心 密苏里大学的研究界在招聘中获得了强有力的机构承诺 并维持世界一流的师资队伍来管理 RBL/LIDR 并开展高等研究 优先病原体。 LIDR 运营共享研究资源，包括最先进的设备和 微生物学、空气生物学、免疫学和动物模型核心设施的专业服务，服务于 校园以及更广泛的地区和国家社区的研究人员的需求。师资队伍和 LIDR 的专业人员是 NIH/NIAID RBL-NBL 网络的一部分，通过协作互动， 促进最佳实践和知识的共享，在实现我们的集体生物防御和 新出现的传染病研究议程。在新冠病毒大流行期间，MU LIDR 及其 RBL 与NBL合作伙伴领导应对疫情并致力于加强疫情防控 通过提供 BSL-3/ABSL-3 培训、专业人员和研究服务， 允许在所有领域做出快速反应，包括动物模型的开发和大量的评估 抗击这一流行病的治疗方法、消毒剂和疫苗平台。目前的长远目标 应用程序是为了维持开发新型医疗对策的主导努力，以对抗 新出现和重新出现的传染病的威胁始终存在且不断变化，同时培训 下一代生物防护科学家和专业人士的杰出骨干。拟议的目标 设施管理、维护和运营、BSL3 实践和生物防护研究的核心 支持服务旨在教育和培训下一代科学家和生物防护专业人员 生物防御和新出现的传染病，并促进和加强新型传染病的发展 预防和治疗由高后果病原体引起的感染的方法，其天然 或故意传播对公共健康和国家安全构成威胁。为实现这些目标，建议 核心将在密西根大学更广泛的传染病界和 NIH/NIAID RBL-NBL 网络中开展工作， 提高研究生产力和发现，并持续分享信息和最佳实践 为了满足 NIH/NIAID 在生物防御和新出现的传染病方面不断变化的优先事项和需求。