Ultra-Broadband Sources for Optical Coherence Tomography

用于光学相干断层扫描的超宽带光源

• 批准号: 7025812
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 48.53万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-28 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7025812
• 关键词: bioengineering /biomedical engineering; electrodes; light intensity; light scattering; luminescence; mathematics; microprocessor /microchip; optical tomography; semiconduction

DESCRIPTION (provided by applicant): The future of optical coherence tomography (OCT) in research and clinical medicine depends, to a large extent, on the development of better light sources. Portable sources with much wider bandwidths and higher single mode power are required to achieve the long standing goal of subcellular imaging in highly scattering tissue for detection and staging of endothelial cancers. Additionally, greater flexibility of center wavelength is required for assessment of tissue composition. This work aims to employ semiconductor wafer bonding technology to create high power, broadband, spectrally shaped, single-chip superluminescent diode (SLD) sources for OCT. This technology enables the in-line integration of several SLD sources comprising different composition emitter regions and operating at different spectral bands. The proposed geometry potentially allows superposition of 4-8 spectral bands with arbitrary weighting of each band, and promises to overcome the inherent losses in existing spectral synthesis techniques. The target specifications for these sources are greater than 200 nanometer (nm) bandwidth and greater than10 milliwatt (mw) fiber coupled power, out of a single chip. If successfully fabricated, this compact device will present researchers and emerging OCT manufacturers with unprecedented depth resolution in tissue imaging applications, enable spectroscopic OCT, and ideally increase the proliferation of high-resolution OCT research.

描述（由申请人提供）： 光学相干断层扫描（OCT）在研究和临床医学中的未来在很大程度上取决于更好的光源的发展。需要更宽的带宽和较高单模式功率的便携式来源，以实现高度散射组织中亚细胞成像的长期目标，以检测和分期分期内皮癌。此外，需要更大的中心波长灵活性来评估组织组成。 这项工作旨在采用半导体晶圆粘结技术来创建OCT的高功率，宽带，频谱，单芯片超发光二极管（SLD）源。该技术使几个SLD来源的在线集成包括不同的组成发射极区域并在不同的光谱频段下运行。所提出的几何形状可能允许每个频段任意加权4-8光谱带叠加，并有望克服现有光谱合成技术中的固有损失。这些来源的目标规格大于200纳米（NM）带宽，大于10毫米（MW）纤维耦合功率，来自单个芯片。如果成功制造，这种紧凑的装置将在组织成像应用中以前所未有的深度分辨率向研究人员和新兴的OCT制造商展示，使光谱OCT能够启用光谱OCT，并理想地增加了高分辨率OCT研究的增殖。