Ultra-Broadband Sources for Optical Coherence Tomography

用于光学相干断层扫描的超宽带光源

• 批准号: 6998524
• 负责人: Vijaysekhar Jayaraman
• 金额: $ 51.51万
• 依托单位: PRAEVIUM RESEARCH, INC.
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-02-28 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6998524
• 关键词: bioengineering /biomedical engineering; electrodes; light intensity; light scattering; luminescence; mathematics; microprocessor /microchip; optical tomography; semiconduction

DESCRIPTION (provided by applicant): The future of optical coherence tomography (OCT) in research and clinical medicine depends, to a large extent, on the development of better light sources. Portable sources with much wider bandwidths and higher single mode power are required to achieve the long standing goal of subcellular imaging in highly scattering tissue for detection and staging of endothelial cancers. Additionally, greater flexibility of center wavelength is required for assessment of tissue composition. This work aims to employ semiconductor wafer bonding technology to create high power, broadband, spectrally shaped, single-chip superluminescent diode (SLD) sources for OCT. This technology enables the in-line integration of several SLD sources comprising different composition emitter regions and operating at different spectral bands. The proposed geometry potentially allows superposition of 4-8 spectral bands with arbitrary weighting of each band, and promises to overcome the inherent losses in existing spectral synthesis techniques. The target specifications for these sources are greater than 200 nanometer (nm) bandwidth and greater than10 milliwatt (mw) fiber coupled power, out of a single chip. If successfully fabricated, this compact device will present researchers and emerging OCT manufacturers with unprecedented depth resolution in tissue imaging applications, enable spectroscopic OCT, and ideally increase the proliferation of high-resolution OCT research.

描述（由申请人提供）： 光学相干断层扫描 (OCT) 在研究和临床医学中的未来在很大程度上取决于更好光源的开发。为了实现在高散射组织中进行亚细胞成像以检测和分期内皮癌的长期目标，需要具有更宽带宽和更高单模功率的便携式源。此外，评估组织成分需要更大的中心波长灵活性。 这项工作旨在采用半导体晶圆键合技术来创建用于 OCT 的高功率、宽带、光谱形状、单芯片超发光二极管 (SLD) 源。该技术能够在线集成多个包含不同成分发射极区域并在不同光谱带下工作的 SLD 源。所提出的几何结构可能允许 4-8 个光谱带的叠加，每个波段具有任意权重，并有望克服现有光谱合成技术中的固有损耗。这些源的目标规格是单芯片大于 200 纳米 (nm) 的带宽和大于 10 毫瓦 (mw) 的光纤耦合功率。如果成功制造，这种紧凑的设备将为研究人员和新兴 OCT 制造商在组织成像应用中提供前所未有的深度分辨率，实现光谱 OCT，并理想地促进高分辨率 OCT 研究的扩散。