Amygdalar influences on cells in the inferior colliculus

杏仁核对下丘细胞的影响

• 批准号: 7053108
• 负责人: Diana Coomes Peterson
• 金额: $ 4.4万
• 依托单位: NORTHEAST OHIO MEDICAL UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-09-21 至 2008-09-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7053108
• 关键词: Chiroptera; amygdala; auditory cortex; auditory nuclei; auditory pathways; auditory stimulus; brain mapping; efferent nerve; electrodes; evoked potentials; inferior colliculus; neural information processing; postdoctoral investigator; single cell analysis; sound perception; stimulus /response

DESCRIPTION (provided by applicant): The long-term goal of this research application is to identify how the amygdala influences auditory perception and function. Specifically it focuses on identifying the effect(s) of amygdalo-collicular projections on cells in the inferior colliculus (IC). The amygdala is thought to play a major role in functions such as emotion, memory, and learning. How such circuitry could influence auditory processing is unknown. The amygdalar projection to the IC influences auditory perception due to previous auditory experience or the emotional state of the animal. The experiments in this application will identify: 1) the physiological response of amygdalar and amygdalo-collicular cells; 2) the morphology and termination pattern of amygdalar projections; and 3) what specific effect(s) amygdalo-collicular projections have on IC cells. This information will contribute to a greater understanding of how descending systems modulate and control auditory processing. It may also provide information about how the auditory system affects the normal aspects of mood, emotion, memory, communication, and learning, as well as pathological conditions associated with tinnitus, depression, bipolar disorders, panic disorders, Alzheimer's, and learning disorders.

描述（由申请人提供）：本研究申请的长期目标是确定杏仁核如何影响听觉感知和功能。具体来说，它侧重于识别杏仁核投射对下丘 (IC) 细胞的影响。杏仁核被认为在情绪、记忆和学习等功能中发挥着重要作用。这种电路如何影响听觉处理尚不清楚。由于先前的听觉经验或动物的情绪状态，杏仁核投射到 IC 会影响听觉感知。本申请中的实验将确定：1）杏仁核和杏仁核细胞的生理反应； 2）杏仁核投射的形态和终止模式； 3) 杏仁核-丘脑投射对 IC 细胞有什么具体影响。这些信息将有助于更好地理解下行系统如何调节和控制听觉处理。它还可以提供有关听觉系统如何影响情绪、情绪、记忆、沟通和学习的正常方面，以及与耳鸣、抑郁、双相情感障碍、恐慌症、阿尔茨海默病和学习障碍相关的病理状况的信息。