Neural Encoding of Communication Sounds in the Amygdala

杏仁核中通讯声音的神经编码

• 批准号: 7754588
• 负责人: Robert Naumann
• 金额: $ 2.85万
• 依托单位: GEORGETOWN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-03 至 2010-10-02
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7754588
• 关键词: Acoustics; Address; Affect; Affective; Amygdaloid structure; Animals; Area; Attention; Auditory; Auditory Perceptual Disorders; Auditory area; Auditory system; Basal Ganglia; Behavior; Brain; Brain Stem; Cell Nucleus; Chiroptera; Chronic; Cognitive; Communication; Communication impairment; Complex; Comprehension; Cues; Echolocation; Goals; Hearing; Heart Rate; Human; Hypothalamic structure; Implant; Inferior Colliculus; Knowledge; Laboratories; Lateral; Lead; Lesion; Libraries; Location; Magnetic Resonance Imaging; Mammals; Measures; Mediating; Memory; Microelectrodes; Mus; Neurons; Nonverbal Communication; Pattern; Perception; Persons; Plastics; Play; Preparation; Process; Prosthesis; Research; Rest; Role; Sampling; Scheme; Scientist; Site; Songbirds; Sound Localization; Speech; Speech Perception; Staging; Stimulus; Stream; Structure; Testing; Thalamic structure; Update; Variant; in vivo; kador; magnocellular; midbrain central gray substance; neuromechanism; neurophysiology; reinforcer; relating to nervous system; response; sensory cortex; showing emotion; social; social communication; sound; stability testing; vocalization

DESCRIPTION (provided by applicant): The amygdala's role in processing cognitive and affective information conveyed by communication sounds is not well studied. In particular, the pattern and spatial organization of activity in the lateral nucleus (LN) of the amygdala, which may contribute to motivating specific responses to these stimuli, is not known. This application is aimed at demonstrating the neurophysiological and neuroanatomical correlates of the amygdala's contribution to the recognition of affect and the meaning of communication sounds. I propose to investigate the selectivity of amygdala neurons for species-specific audiovocal communication sounds in the spatial and temporal domains in the LN of the mustached bat. Diversity and richness in the repertoire of communication sounds or "calls" is expected to drive neurons of the LN to different degrees and in different locations. In addition, the complexity of the acoustic stimulus may determine the complexity of temporal response patterns within the amygdala. Microelectrodes will be used to record the activity of single neurons and neuronal ensembles in response to social call presentations. In addition to histological verification of recording sites, magnetic resonance imaging will enable in-vivo verification of the precise location of recording sites early on in our chronic preparation. This research will constitute an important step toward understanding normal and disordered auditory processing of social calls in the amygdala. The amygdala is interconnected with both the auditory cortex and thalamus and also projects to the inferior colliculus. Therefore, it is critical to understand how sounds are represented and processed here in order to fully comprehend the functioning of the auditory structures and any auditory prosthetic devices that may be implanted therein. RELEVANCE: The amygdala is a brain structure that is known to play an important role in social communication in many animals ranging from mice to humans. Specifically, the amygdala may help a person to have an appropriate, adaptive response to vocal expressions of emotion. Understanding how the amygdala is organized to serve this purpose will lead to a better understanding of several communication disorders where auditory memory and perception are impaired.

描述（由申请人提供）：杏仁核在处理由交流声音传达的认知和情感信息中的作用尚未得到充分研究。特别是，杏仁核外侧核（LN）活动的模式和空间组织可能有助于激发对这些刺激的特定反应，但目前尚不清楚。该应用旨在证明杏仁核对情感识别和交流声音意义的贡献的神经生理学和神经解剖学相关性。我建议研究小胡子蝙蝠 LN 的空间和时间域中杏仁核神经元对物种特定的音频声音通信声音的选择性。通信声音或“呼叫”的多样性和丰富性预计会在不同程度上和不同位置驱动 LN 的神经元。此外，声刺激的复杂性可以决定杏仁核内时间反应模式的复杂性。微电极将用于记录单个神经元和神经元群响应社交呼叫演示的活动。除了记录位点的组织学验证之外，磁共振成像还将在我们长期准备的早期对记录位点的精确位置进行体内验证。这项研究将向理解杏仁核社交呼唤的正常和无序听觉处理迈出重要一步。杏仁核与听觉皮层和丘脑相互连接，并且还投射到下丘。因此，为了充分理解听觉结构和可能植入其中的任何听觉假体装置的功能，了解声音在这里如何表示和处理是至关重要的。 相关性：杏仁核是一种大脑结构，已知在从小鼠到人类的许多动物的社交交流中发挥着重要作用。具体来说，杏仁核可以帮助一个人对情绪的声音表达做出适当的、适应性的反应。了解杏仁核如何组织来实现这一目的将有助于更好地理解几种听觉记忆和感知受损的沟通障碍。