Amygdalar modulation of processing in auditory cortex

杏仁核对听觉皮层处理的调节

• 批准号: 8220894
• 负责人: Diana Coomes Peterson
• 金额: $ 14.33万
• 依托单位: IOWA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-03-01 至 2015-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8220894
• 关键词: Acoustics; Affect; Amygdaloid structure; Animals; Area; Attention; Auditory; Auditory Hallucination; Auditory Perception; Auditory area; Axon; Basal Nucleus of Meynert; Behavioral; Bilateral; Bipolar Disorder; Brain; Brain Stem; Brain region; Canis familiaris; Cortical Column; Crying; Cues; Data; Disease; Electric Stimulation; Electrodes; Emotional; Emotions; Functional disorder; Future; Goals; Human; Individual; Ipsilateral; Knowledge; Label; Lead; Learning; Left; Link; Location; Mediating; Memory; Mental disorders; Modeling; Monkeys; Morphology; Mothers; Neurons; Pathway interactions; Pattern; Perception; Personal Communication; Process; Rattus; Research; Research Personnel; Role; Schizophrenia; Signal Transduction; Speech; Stimulus; Techniques; Testing; Tinnitus; Tracer; auditory stimulus; conditioning; insight; public health relevance; research study; response; sensory stimulus; sound

DESCRIPTION (provided by applicant): The goal of this research is to understand how the amygdala (AM; a brain center that processes the emotional significance of sensory stimuli) influences the processing of auditory information in auditory cortex (AC). Individuals/animals pay more attention to significant versus insignificant stimuli. The mechanisms associated with this process have not been determined. It is presumed that information about the significance of auditory stimuli is transmitted to AC via direct and indirect projections from the AM, and that subsequent changes in cortical activity alter the attention of the animal to relevant auditory cues. Conditioning experiments that enhance the behavioral relevance of auditory cues have been shown to elicit both short and long-term changes in the spiking activity of neurons in auditory cortex (reviewed by Weinberger, 2007; Suga, 2008). The specific goals of this proposal are to provide information about the morphology and termination pattern of the direct amygdalo-auditory cortex projection and begin to clarify the function of amygdalar inputs on cortical processing. My general hypothesis is that the direct AM-AC projection terminated throughout the AC and influences the spiking response of AC neurons to sound. Relevance: The amygdala mediates emotion, and influences memory and learning. Abnormal processing in the amygdala has been linked to numerous psychiatric disorders that include auditory hallucinations (e.g., schizophrenia, bipolar disorder). It is likely that these auditory hallucinations are initiated by amygdalar projections to AC. By understanding the role of amygdalo-cortical projections, we can obtain a clearer picture of: 1) how normal auditory perception is processed, and 2) how abnormal processing can results in these auditory dysfunctions. PUBLIC HEALTH RELEVANCE: These studies will provide a better understanding of how processing of acoustic signals, including speech, is modified by an individual's emotional state. They may also further our understanding of abnormal auditory perceptions such as tinnitus or the auditory hallucinations associated with psychiatric disorders such as schizophrenia and bipolar disorder.

描述（由申请人提供）：本研究的目标是了解杏仁核（AM；处理感觉刺激的情感意义的大脑中枢）如何影响听觉皮层（AC）中听觉信息的处理。与无关紧要的刺激相比，个体/动物更关注重要的刺激。与该过程相关的机制尚未确定。据推测，有关听觉刺激重要性的信息通过 AM 的直接和间接投射传递到 AC，并且皮层活动的后续变化改变了动物对相关听觉线索的注意力。增强听觉线索行为相关性的条件实验已被证明可以引起听觉皮层神经元尖峰活动的短期和长期变化（Weinberger，2007 年综述；Suga，2008 年）。该提案的具体目标是提供有关直接杏仁核听觉皮层投射的形态和终止模式的信息，并开始阐明杏仁核输入对皮质处理的功能。我的一般假设是，直接 AM-AC 投射在整个 AC 中终止，并影响 AC 神经元对声音的尖峰响应。相关性：杏仁核调节情绪，影响记忆和学习。杏仁核的异常处理与许多精神疾病有关，包括幻听（例如精神分裂症、双相情感障碍）。这些幻听很可能是由杏仁核对 AC 的投射引发的。通过了解杏仁核皮质投射的作用，我们可以更清楚地了解：1）正常听觉感知是如何处理的，2）异常处理如何导致这些听觉功能障碍。 公共健康相关性：这些研究将有助于更好地理解声音信号（包括语音）的处理如何受到个人情绪状态的影响。它们还可能进一步加深我们对异常听觉感知的理解，例如耳鸣或与精神疾病（例如精神分裂症和双相情感障碍）相关的幻听。