Cortical Projections to the Inferior Colliculus

皮质投射到下丘

• 批准号: 6612955
• 负责人: Diana Coomes Peterson
• 金额: $ 2.42万
• 依托单位: UNIVERSITY OF LOUISVILLE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6612955
• 关键词: Animalia; auditory nuclei; brain mapping; electron microscopy; gamma aminobutyrate; inferior colliculus; medial geniculate body; olivary body; predoctoral investigator

DESCRIPTION (provided by applicant): Descending projections from auditory cortex have been postulated to play a role in a wide variety of functions including selective attention, sound localization, gain control, and frequency selectivity. One of the largest of the descending projections is to the inferior colliculus. We intend to use a combination of anatomical tracing and electron microscopic techniques to elucidate the targets of these projections. Cortical projections terminate in the same area of the inferior colliculus as collicular cells that have ascending projections and cells that have descending projections. Therefore our first two goals are to identify if these cortical projections contact cells in the inferior colliculus that have ascending projections to the medial geniculate, or cells that have descending projections to the superior olivary complex and cochlear nucleus. To better understand the functional role of the pathways, our third goal is to determine whether cells in the inferior colliculus that contain y-aminobutyric acid (GABA), an important inhibitory neurotransmitter, are also contacted by cortical projections. Answers to these questions are necessary to ascertain which brainstem circuits are modulated by cortical projections and what role they may play in both normal and diseased auditory systems.

描述（由申请人提供）：听觉皮层的下降投射 已被假定在多种功能中发挥作用，包括 选择性注意、声音定位、增益控制和频率 选择性。最大的下降预测之一是向下的预测 丘。我们打算结合使用解剖追踪和电子 微观技术来阐明这些预测的目标。皮质 突起终止于下丘与丘的同一区域 具有上升投影的细胞和具有下降投影的细胞 预测。因此，我们的前两个目标是确定这些皮质是否 突起接触下丘中具有上升的细胞 向内侧膝状体的投射，或具有下降投射的细胞 至上橄榄复合体和耳蜗核。为了更好地理解 通路的功能作用，我们的第三个目标是确定细胞是否处于 下丘含有γ-氨基丁酸（GABA），是一种重要的 抑制性神经递质也通过皮质投射接触。答案 这些问题对于确定哪些脑干回路是必要的 由皮质投射调节以及它们在正常和 听觉系统患病。